Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy

Autor: Frank L. van de Veerdonk, Giorgia Renga, Marilena Pariano, Marina M. Bellet, Giuseppe Servillo, Francesca Fallarino, Antonella De Luca, Rossana G. Iannitti, Danilo Piobbico, Marco Gargaro, Giorgia Manni, Fiorella D’Onofrio, Claudia Stincardini, Luigi Sforna, Monica Borghi, Marilena Castelli, Stefania Pieroni, Vasileios Oikonomou, Valeria R. Villella, Matteo Puccetti, Stefano Giovagnoli, Roberta Galarini, Carolina Barola, Luigi Maiuri, Maria Agnese Della Fazia, Barbara Cellini, Vincenzo Nicola Talesa, Charles A. Dinarello, Claudio Costantini, Luigina Romani

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)

Autophagy selectively degrades aggregation-prone misfolded proteins caused by defective cellular proteostasis. However, the complexity of autophagy may prevent the full appreciation of how its modulation could be used as a therapeutic strategy in dis

Externí odkaz: https://doaj.org/article/37bfe8f4acef4696892b52f446b0f266

IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut

Autor: Giorgia Renga, Silvia Moretti, Vasilis Oikonomou, Monica Borghi, Teresa Zelante, Giuseppe Paolicelli, Claudio Costantini, Marco De Zuani, Valeria Rachela Villella, Valeria Raia, Rachele Del Sordo, Andrea Bartoli, Monia Baldoni, Jean-Christophe Renauld, Angelo Sidoni, Enrico Garaci, Luigi Maiuri, Carlo Pucillo, Luigina Romani

Publikováno v: Cell Reports, Vol 23, Iss 6, Pp 1767-1778 (2018)

Summary: Candida albicans is implicated in intestinal diseases. Identifying host signatures that discriminate between the pathogenic versus commensal nature of this human commensal is clinically relevant. In the present study, we identify IL-9 and ma

Externí odkaz: https://doaj.org/article/e763d689a3124ccba323cbc4c68767f6

FOXO1 Content Is Reduced in Cystic Fibrosis and Increases with IGF-I Treatment

Autor: Arianna Smerieri, Luisa Montanini, Luigi Maiuri, Sergio Bernasconi, Maria E. Street

Publikováno v: International Journal of Molecular Sciences, Vol 15, Iss 10, Pp 18000-18022 (2014)

Cystic fibrosis-related diabetes is to date the most frequent complication in cystic fibrosis (CF). The mechanisms underlying this condition are not well understood, and a possible role of insulin resistance is debated. We investigated insulin signal

Externí odkaz: https://doaj.org/article/15078843f3874116aa378f9503413fcf

Collective rotational motion of freely expanding T84 epithelial cell colonies

Autor: Flora Ascione, Sergio Caserta, Speranza Esposito, Valeria Rachela Villella, Luigi Maiuri, Mehrana R. Nejad, Amin Doostmohammadi, Julia M. Yeomans, Stefano Guido

Publikováno v: Ascione, F, Caserta, S, Esposito, S, Rachela, V V, Maiuri, L, Nejad, M R, Doostmohammadi, A, Yeomans, J M & Guido, S 2023, ' Collective rotational motion of freely expanding T84 epithelial cell colonies ', Journal of the Royal Society Interface, vol. 20, no. 199, 20220719 . https://doi.org/10.1098/rsif.2022.0719

Coordinated rotational motion is an intriguing, yet still elusive mode of collective cell migration, which is relevant in pathological and morphogenetic processes. Most of the studies on this topic have been carried out on epithelial cells plated on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c62418fb0cebc49edd0131c002cc5d5
https://doi.org/10.1098/rsif.2022.0719

Cystic Fibrosis: New Insights into Therapeutic Approaches

Autor: Valeria Raia, Luigi Maiuri, Antonella Tosco, Valeria Rachela Villella, Guido Kroemer

Publikováno v: Current Respiratory Medicine Reviews. 15:174-186

Since the identification of Cystic Fibrosis (CF) as a disease in 1938 until 2012, only therapies to treat symptoms rather than etiological therapies have been used to treat the disease. Over the last few years, new technologies have been developed, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b043ddb7239cf8f2fd717fded0a47b18
https://doi.org/10.2174/1573398x15666190702151613