Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Luigi Iconaru"'
Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
Autor:
Maksym Tsytlonok, Hugo Sanabria, Yuefeng Wang, Suren Felekyan, Katherina Hemmen, Aaron H. Phillips, Mi-Kyung Yun, M. Brett Waddell, Cheon-Gil Park, Sivaraja Vaithiyalingam, Luigi Iconaru, Stephen W. White, Peter Tompa, Claus A. M. Seidel, Richard Kriwacki
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The cyclin-dependent kinase (Cdk) inhibitor p27Kip1 (p27) folds upon binding to Cdk/cyclin complexes and during cell cycle progression p27 becomes phosphorylated, which triggers its ubiquitination and degradation. Here the authors use an integrated a
Externí odkaz:
https://doaj.org/article/68150062dc9d4c4082ba200461d73f70
Autor:
Mariell Pettersson, David Bliman, Jimmy Jacobsson, Jesper R Nilsson, Jaeki Min, Luigi Iconaru, R Kiplin Guy, Richard W Kriwacki, Joakim Andréasson, Morten Grøtli
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124423 (2015)
Small molecule nonpeptidic mimics of α-helices are widely recognised as protein-protein interaction (PPIs) inhibitors. Protein-protein interactions mediate virtually all important regulatory pathways in a cell, and the ability to control and modulat
Externí odkaz:
https://doaj.org/article/6029b62f2cd9436aa042c3db3168a3cb
Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction.
Autor:
Mariell Pettersson, Maria Quant, Jaeki Min, Luigi Iconaru, Richard W Kriwacki, M Brett Waddell, R Kiplin Guy, Kristina Luthman, Morten Grøtli
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0137867 (2015)
The transcription factor p53 is the main tumour suppressor in cells and many cancer types have p53 mutations resulting in a loss of its function. In tumours that retain wild-type p53 function, p53 activity is down-regulated by MDM2 (human murine doub
Externí odkaz:
https://doaj.org/article/005ed7b47b1e46878acb025bd57235f1