Suppression of the KRAS-NRF2 axis shifts arginine into the phosphocreatine energy system in pancreatic cancer cells

Autor: Eros Di Giorgio, Himanshi Choudhary, Annalisa Ferino, Ylenia Cortolezzis, Emiliano Dalla, Francesca D’Este, Marina Comelli, Valentina Rapozzi, Luigi E. Xodo

Publikováno v: iScience, Vol 26, Iss 12, Pp 108566- (2023)

Summary: In pancreatic ductal adenocarcinomas (PDAC), the KRASG12D-NRF2 axis controls cellular functions such as redox homeostasis and metabolism. Disruption of this axis through suppression of NRF2 leads to profound reprogramming of metabolism. Unbi

Externí odkaz: https://doaj.org/article/155673efb0a645f6bd1db83427ce85ed

hnRNPA1/UP1 Unfolds KRAS G‑Quadruplexes and Feeds a Regulatory Axis Controlling Gene Expression

Autor: Annalisa Ferino, Julien Marquevielle, Himanshi Choudhary, Giorgio Cinque, Coralie Robert, Anne Bourdoncle, Raffaella Picco, Jean-Louis Mergny, Gilmar F. Salgado, Luigi E. Xodo

Publikováno v: ACS Omega, Vol 6, Iss 49, Pp 34092-34106 (2021)

Externí odkaz: https://doaj.org/article/6d6584fbad484cc3a33b03455540ba6a

hnRNPA1/UP1 Unfolds KRAS G-Quadruplexes and Feeds a Regulatory Axis Controlling Gene Expression

Autor: Gilmar F. Salgado, Jean-Louis Mergny, Giorgio Cinque, Coralie Robert, Luigi E. Xodo, Annalisa Ferino, Raffaella Picco, Julien Marquevielle, Anne Bourdoncle, Himanshi Choudhary

Publikováno v: ACS Omega
ACS Omega, ACS Publications, 2021, 6 (49), pp.34092-34106. ⟨10.1021/acsomega.1c05538⟩
ACS Omega, Vol 6, Iss 49, Pp 34092-34106 (2021)

Recent studies have proven that the genetic landscape of pancreatic cancer is dominated by the KRAS oncogene. Its transcription is controlled by a G-rich motif (called 32R) located immediately upstream of the TSS. 32R may fold into a G-quadruplex (G4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf032e5b3d4d5b55e3c214b92d1a1572
http://europepmc.org/articles/PMC8675163

Photosensitization of pancreatic cancer cells by cationic alkyl-porphyrins in free form or engrafted into POPC liposomes: The relationship between delivery mode and mechanism of cell death

Autor: Eros Di Giorgio, Annalisa Ferino, Himanshi Choudhary, Phillip M.G. Löffler, Francesca D'Este, Valentina Rapozzi, Alexander Tikhomirov, Andrey Shchekotikhin, Stefan Vogel, Luigi E. Xodo

Publikováno v: Di Giorgio, E, Ferino, A, Choudhary, H, Löffler, P M G, D'Este, F, Rapozzi, V, Tikhomirov, A, Shchekotikhin, A, Vogel, S & Xodo, L E 2022, ' Photosensitization of pancreatic cancer cells by cationic alkyl-porphyrins in free form or engrafted into POPC liposomes : The relationship between delivery mode and mechanism of cell death ', Journal of Photochemistry and Photobiology B: Biology, vol. 231, 112449 . https://doi.org/10.1016/j.jphotobiol.2022.112449

Cationic porphyrins bearing an alkyl side chain of 14 (2b) or 18 (2d) carbons dramatically inhibit proliferation of pancreatic cancer cells following treatment with light. We have compared two different ways of delivering porphyrin 2d: either in free

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d662aad624f4c7dc5dc79a498a03b32
https://pubmed.ncbi.nlm.nih.gov/35504235

Effect of DNA Glycosylases OGG1 and Neil1 on Oxidized G-Rich Motif in the KRAS Promoter

Autor: Luigi E. Xodo, Annalisa Ferino

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1137, p 1137 (2021)

The promoter of the Kirsten ras (KRAS) proto-oncogene contains, upstream of the transcription start site, a quadruplex-forming motif called 32R with regulatory functions. As guanine under oxidative stress can be oxidized to 8-oxoguanine (8OG), we inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e0a7dabacee0ed2de416ba98548cef