Zobrazeno 1 - 10
of 311
pro vyhledávání: '"Luigi Casella"'
Autor:
Eliana Lo Presti, Fabio Schifano, Chiara Bacchella, Laura Santagostini, Luigi Casella, Enrico Monzani
Publikováno v:
Molecules, Vol 28, Iss 11, p 4487 (2023)
A challenge in mimicking tyrosinase activity using model compounds is to reproduce its enantioselectivity. Good enantioselection requires rigidity and a chiral center close to the active site. In this study, the synthesis of a new chiral copper compl
Externí odkaz:
https://doaj.org/article/285f08243b87477194bbe6082d1c0982
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 791 (2023)
α-Synuclein (αS), dopamine (DA), and iron have a crucial role in the etiology of Parkinson’s disease. The present study aims to investigate the interplay between these factors by analyzing the DA/iron interaction and how it is affected by the pre
Externí odkaz:
https://doaj.org/article/7660a19c9c214abbaeeee88841043b83
Autor:
Chiara Bacchella, Francesca Camponeschi, Paulina Kolkowska, Arian Kola, Isabella Tessari, Maria Camilla Baratto, Marco Bisaglia, Enrico Monzani, Luigi Bubacco, Stefano Mangani, Luigi Casella, Simone Dell’Acqua, Daniela Valensin
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 287 (2023)
α-Synuclein (αSyn) constitutes the main protein component of Lewy bodies, which are the pathologic hallmark in Parkinson’s disease. αSyn is unstructured in solution but the interaction of αSyn with lipid membrane modulates its conformation by i
Externí odkaz:
https://doaj.org/article/ddf2649895b1479687fce0f3f6237b92
Autor:
Chiara Bacchella, Silvia Gentili, Sara Ida Mozzi, Enrico Monzani, Luigi Casella, Matteo Tegoni, Simone Dell’Acqua
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10726 (2022)
Tau is a widespread neuroprotein that regulates the cytoskeleton assembly. In some neurological disorders, known as tauopathies, tau is dissociated from the microtubule and forms insoluble neurofibrillary tangles. Tau comprises four pseudorepeats (R1
Externí odkaz:
https://doaj.org/article/04afc79af1cc4885880e112d77ef6faf
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5190 (2021)
The redox chemistry of copper(II) is strongly modulated by the coordination to amyloid-β peptides and by the stability of the resulting complexes. Amino-terminal copper and nickel binding motifs (ATCUN) identified in truncated Aβ sequences starting
Externí odkaz:
https://doaj.org/article/140f2f79104e40a592ab512a2ec86f8f
Publikováno v:
Antioxidants, Vol 10, Iss 6, p 824 (2021)
Neuromelanin (NM) accumulates in catecholamine long-lived brain neurons that are lost in neurodegenerative diseases. NM is a complex substance made of melanic, peptide and lipid components. NM formation is a natural protective process since toxic end
Externí odkaz:
https://doaj.org/article/fd930e8613144e91a3b772c663219e7e
Autor:
Chiara Bacchella, James T. Brewster, Steffen Bähring, Simone Dell’Acqua, Harrison D. Root, Gregory D. Thiabaud, James F. Reuther, Enrico Monzani, Jonathan L. Sessler, Luigi Casella
Publikováno v:
Molecules, Vol 25, Iss 21, p 5044 (2020)
The peroxidase activity of hemin-peptide complexes remains a potential factor in oxidative damage relevant to neurodegeneration. Here, we present the effect of temperature, ionic strength, and pH relevant to pathophysiological conditions on the dynam
Externí odkaz:
https://doaj.org/article/33fc3ebe28194fffa7663bf54a5c8cb0
Autor:
Simone Dell’Acqua, Elisa Massardi, Enrico Monzani, Giuseppe Di Natale, Enrico Rizzarelli, Luigi Casella
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7553 (2020)
We investigate the interaction of hemin with four fragments of prion protein (PrP) containing from one to four histidines (PrP106–114, PrP95–114, PrP84–114, PrP76–114) for its potential relevance to prion diseases and possibly traumatic brain
Externí odkaz:
https://doaj.org/article/8a2ef030479549a88a32745a640de1c6
Autor:
Roberta Besio, Roberta Gioia, Federica Cossu, Enrico Monzani, Stefania Nicolis, Lucia Cucca, Antonella Profumo, Luigi Casella, Ruggero Tenni, Martino Bolognesi, Antonio Rossi, Antonella Forlino
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58792 (2013)
Prolidase is the only human enzyme responsible for the digestion of iminodipeptides containing proline or hydroxyproline at their C-terminal end, being a key player in extracellular matrix remodeling. Prolidase deficiency (PD) is an intractable loss
Externí odkaz:
https://doaj.org/article/220c7167155249ec8def52abd4c9c625
Autor:
Mireille Engelen, Renzo Vanna, Chiara Bellei, Fabio A Zucca, Kazumasa Wakamatsu, Enrico Monzani, Shosuke Ito, Luigi Casella, Luigi Zecca
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48490 (2012)
Neuromelanins (NMs) are neuronal pigments of melanic-lipidic type which accumulate during aging. They are involved in protective and degenerative mechanisms depending on the cellular context, however their structures are still poorly understood. NMs
Externí odkaz:
https://doaj.org/article/612df313c4f54d11a2c1062e9c1b1463