Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Luigi Barbarossa"'
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-31 (2023)
Abstract Background Integration site (IS) analysis is a fundamental analytical platform for evaluating the safety and efficacy of viral vector based preclinical and clinical Gene Therapy (GT). A handful of groups have developed standardized bioinform
Externí odkaz:
https://doaj.org/article/d7e664d64c5543e5bfcd857847f6fcce
Autor:
Giulia Escobar, Luigi Barbarossa, Giulia Barbiera, Margherita Norelli, Marco Genua, Anna Ranghetti, Tiziana Plati, Barbara Camisa, Chiara Brombin, Davide Cittaro, Andrea Annoni, Attilio Bondanza, Renato Ostuni, Bernhard Gentner, Luigi Naldini
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME
Externí odkaz:
https://doaj.org/article/d5447487f0d9463493bef78ed95681ca
Autor:
Robert N. Plasschaert, Mark P. DeAndrade, Fritz Hull, Quoc Nguyen, Tara Peterson, Aimin Yan, Mariana Loperfido, Cristina Baricordi, Luigi Barbarossa, John K. Yoon, Yildirim Dogan, Zeenath Unnisa, Jeffrey W. Schindler, Niek P. van Til, Luca Biasco, Chris Mason
Publikováno v:
Molecular Therapy. 30:3209-3225
Hematopoietic stem/progenitor cell gene therapy (HSPC-GT) has shown clear neurological benefit in rare diseases, which is achieved through the engraftment of genetically modified microglia-like cells (MLCs) in the brain. Still, the engraftment dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5df9c34055a087315833104af0a261
https://doi.org/10.1016/j.ymthe.2022.05.022
https://doi.org/10.1016/j.ymthe.2022.05.022
Genetically engineered microglia-like cells have therapeutic potential for neurodegenerative disease
Autor:
Luigi Barbarossa, Niek P. van Til, Tara Peterson, Cristina Baricordi, Christopher E. Mason, Robert N. Plasschaert, Zeenath Unnisa, Mariana Loperfido, Jeffrey W. Schindler, Aimin Yan, Fritz Hull, Yildirim Dogan, Mark P. DeAndrade, John K. Yoon, Luca Biasco, Quoc Nguyen
Hematopoietic stem/progenitor cell gene therapy (HSPC-GT) results in the engraftment of genetically modified microglia-like cells (MLCs) in the brain. While HSPC-GT has shown a clear neurological benefit in the clinic for specific rare diseases, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f54bc3f10bedc2465a41f5e0e4cb191
https://doi.org/10.1101/2021.09.16.460703
https://doi.org/10.1101/2021.09.16.460703
Autor:
Mariana Loperfido, Cristina Baricordi, Aimin Yan, Luigi Barbarossa, Quoc Nguyen, Ingrid Abrahamsen, Stephanie Cherqui, Diana Escolar, Chris Mason, Luca Biasco
Publikováno v:
Molecular Genetics and Metabolism. 135:S75-S76
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f310dc414d974e1b42bf2315a261df5b
https://doi.org/10.1016/j.ymgme.2021.11.193
https://doi.org/10.1016/j.ymgme.2021.11.193
Autor:
Luca Biasco, Cristina Baricordi, Mariana Loperfido, Aimin Yan, Luigi Barbarossa, Ingrid Abrahamsen, Azadeh Golipour, Chris Mason
Publikováno v:
Molecular Genetics and Metabolism. 135:S23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc644158fca280ca222b74d2fd5bc737
https://doi.org/10.1016/j.ymgme.2021.11.041
https://doi.org/10.1016/j.ymgme.2021.11.041
Autor:
Margherita Norelli, Renato Ostuni, Giulia Escobar, Barbara Camisa, Attilio Bondanza, Bernhard Gentner, Chiara Brombin, Davide Cittaro, Andrea Annoni, Tiziana Plati, Marco Genua, Luigi Naldini, Luigi Barbarossa, Giulia Barbiera, Anna Ranghetti
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
Immunotherapy is emerging as a new pillar of cancer treatment with potential to cure. However, many patients still fail to respond to these therapies. Among the underlying factors, an immunosuppressive tumor microenvironment (TME) plays a major role.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0f288dbf23ef1148f63d56ecb93f13
https://doaj.org/article/d5447487f0d9463493bef78ed95681ca
https://doaj.org/article/d5447487f0d9463493bef78ed95681ca
Autor:
Luigi Barbarossa, Aimin Yan, Christopher E. Mason, Cristina Baricordi, Mariana Loperfido, Azadeh Golipour, Hareesh Chamarthi, Luca Biasco
Publikováno v:
Transplantation and Cellular Therapy. 27:S34-S35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94ca7abed86ac1044f30f0077b006da2
https://doi.org/10.1016/s2666-6367(21)00062-2
https://doi.org/10.1016/s2666-6367(21)00062-2
Autor:
Mercedes Segura, Cristina Baricordi, Christopher E. Mason, Azadeh Golipour, Luca Biasco, Aimin Yan, Mariana Loperfido, Luigi Barbarossa
Publikováno v:
Blood. 136:28-29
Human hematopoietic/stem progenitor CD34+ cells (HSPCs) are the core components of ex vivo lentiviral gene therapy (GT) for the treatment of rare monogenic diseases. Assessment of CD34+ composition before and after genetic modification as well as in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2afde762760c74f8792b1fcb6e31c024
https://doi.org/10.1182/blood-2020-141057
https://doi.org/10.1182/blood-2020-141057
Autor:
Luca Biasco, Christopher E. Mason, Hareesh Chamarthi, Mariana Loperfido, Rachel Ciotti, Cristina Baricordi, Luigi Barbarossa, Leslie K. Jacobsen, Aneal Khan, Azadeh Golipour, Aimin Yan
Publikováno v:
Molecular Genetics and Metabolism. 132:S18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a370fe104685d2d4f7ee42c495dfd4f
https://doi.org/10.1016/j.ymgme.2020.12.022
https://doi.org/10.1016/j.ymgme.2020.12.022