Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Luigi, Scotto"'
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background Pralatrexate (PDX) is a novel antifolate approved for the treatment of patients with relapsed/refractory peripheral T-cell lymphoma, but some patients exhibit intrinsic resistance or develop acquired resistance. Here, we evaluated
Externí odkaz:
https://doaj.org/article/505495238d0e4a3cb8ed7d4fcdd6d823
Autor:
Matko Kalac, Michael Mangone, Alison Rinderspacher, Shi-Xian Deng, Luigi Scotto, Michael Markson, Mukesh Bansal, Andrea Califano, Donald W. Landry, Owen A. O'Connor
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101884- (2020)
Summary: We previously identified the N-quinoline-benzenesulfonamide (NQBS) scaffold as a potent inhibitor of nuclear factor-κB (NF-κB) translocation. Now, we report the structure-activity relationship of compounds with the NQBS scaffold in models
Externí odkaz:
https://doaj.org/article/e0b18e1d4cf449fbb9c711d9682a3306
Autor:
Ipsita Pal, Andre M. Sardinha Grilo, Alec Gaspary, Sohani Das Sharma, Luigi Scotto, Owen A. O'Connor, Marko Jovanovic, Changchun Deng, Luke E. Berchowitz
Publikováno v:
Blood Advances. 6:4157-4161
Autor:
Susan E. Bates, Antonio T. Fojo, Yves Pommier, Owen A. O'Connor, Luigi Scotto, Lubov Petrukhin, Agnes Basseville, William C. Reinhold, Arup R. Chakraborty, Andrés Aguilera, Robert W. Robey, Thomas Litman, Maryam Safari
Supplementary Figures 1-7 and Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f04256416c03461c4a156fd5e33fa8
https://doi.org/10.1158/1541-7786.22526984
https://doi.org/10.1158/1541-7786.22526984
Autor:
Owen A. O'Connor, Olivier Elemento, Akanksha Verma, Serge Cremers, Renu Nandakumar, Jimmy Duong, Ying Wei, Xavier Jirau Serrano, Luigi Scotto, Yulissa Gonzalez, Paul M. Johannet, Kelly Zullo, Maximilian Lombardo, Sathyen A. Prabhu, Jennifer E. Amengual
Purpose: Pan-class I/II histone deacetylase (HDAC) inhibitors are effective treatments for select lymphomas. Isoform-selective HDAC inhibitors are emerging as potentially more targeted agents. ACY-1215 (ricolinostat) is a first-in-class selective HDA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b94422791cde262884e5e71d6e884a0
https://doi.org/10.1158/1078-0432.c.6525519.v1
https://doi.org/10.1158/1078-0432.c.6525519.v1
Autor:
Owen A. O'Connor, Daruka Mahadevan, Jimmy Duong, Serge Cremers, Renu Nandakumar, Yinghui Mao, Jennifer E. Amengual, Luigi Scotto, Michael Mangone, Xavier Jirau-Serrano, Laurence Cooke, Yige Guo, Kelly M. Zullo
Purpose: Aurora A kinase (AAK) is expressed exclusively during mitosis, and plays a critical role in centrosome duplication and spindle formation. Alisertib is a highly selective AAK inhibitor that has demonstrated marked clinical activity of alisert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518812210463516dac33e39bd5882431
https://doi.org/10.1158/1078-0432.c.6523485.v1
https://doi.org/10.1158/1078-0432.c.6523485.v1
Autor:
Owen A. O'Connor, Susan E. Bates, Ronald Realubit, Charles Karan, Changchun Deng, Jennifer E. Amengual, Govind Bhagat, Yuan Zhang, Ying Wei, Tiffany Thomas, Serge Cremers, Kenneth P. Olive, Stephen A. Sastra, Carmine F. Palermo, Luigi Scotto, Kelly M. Zullo, Xavier Jirau-Serrano, Salvia Jain
Purpose: T-cell lymphomas (TCL) are aggressive diseases, which carry a poor prognosis. The emergence of new drugs for TCL has created a need to survey these agents in a rapid and reproducible fashion, to prioritize combinations which should be priori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd2dfddf7581dd54f3a7709c025e733
https://doi.org/10.1158/1078-0432.c.6524241.v1
https://doi.org/10.1158/1078-0432.c.6524241.v1
Autor:
Owen A. O'Connor, Michael M. Shen, Jennifer Amengual, Jairo Baquero Buitrago, Enrica Marchi, Matko Kalac, Luca Paoluzzi, Marianna Kruithof-de Julio, Luigi Scotto
PDF file, 43KB.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8adc69354fbe7b23c5a0e088d004a9
https://doi.org/10.1158/1078-0432.22444259
https://doi.org/10.1158/1078-0432.22444259
Autor:
Owen A. O'Connor, Simon Jones, Yuan Zhang, Serge Cremers, Hongfeng Jiang, Jennifer Heinen, Dejan Radeski, Xavier Jirau-Serrano, Luigi Scotto, Govind Bhagat, Daniela Hoehn, Kelly Zullo, Maximilian Lombardo, Paul Johannet, Jennifer E. Amengual
Purpose: Pan-class histone deacetylase (HDAC) inhibitors are effective treatments for select lymphomas. Isoform-selective HDAC inhibitors are emerging as potentially more targeted agents. HDAC6 is a class IIb deacetylase that facilitates misfolded pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65c138e0e4b7e1256e44af768ef5d82
https://doi.org/10.1158/1078-0432.c.6524379.v1
https://doi.org/10.1158/1078-0432.c.6524379.v1
Autor:
Owen A. O'Connor, Susan E. Bates, Ronald Realubit, Charles Karan, Changchun Deng, Jennifer E. Amengual, Govind Bhagat, Yuan Zhang, Ying Wei, Tiffany Thomas, Serge Cremers, Kenneth P. Olive, Stephen A. Sastra, Carmine F. Palermo, Luigi Scotto, Kelly M. Zullo, Xavier Jirau-Serrano, Salvia Jain
Supplementary Figures 1-2, Supplementary Table 1. Supplementary Figure 1: Highthroughput Matrix For H9 and HH. Highthroughput screen was used to determine the synergistic interaction in vitro in H9 and HH T-cell lines. (A) Depicts the observed percen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f762b80976191778cfffa83497553ca
https://doi.org/10.1158/1078-0432.22459545.v1
https://doi.org/10.1158/1078-0432.22459545.v1