Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Luigi, Portella"'
Autor:
Luigi Portella, Giulia Bertolini, Giuseppe Guardascione, Dario Guido Di Febbraro, Caterina Ieranò, Crescenzo D'Alterio, Giuseppina Rea, Maria Napolitano, Sara Santagata, Anna Maria Trotta, Rosa Camerlingo, Emilia Scarpa, Sabrina Chiara Cecere, Alessandro Ottaiano, Giuliano Palumbo, Alessandro Morabito, Teresa Somma, Giuseppe De Rosa, Laura Mayol, Roberto Pacelli, Sandro Pignata, Stefania Scala
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35524- (2024)
Background: Circulating Tumor Cells (CTCs) represent a small, heterogeneous population that comprise the minority of cells able to develop metastasis. To trap and characterize CTCs with metastatic attitude, a CXCL12-loaded hyaluronic-gel (CLG) was de
Externí odkaz:
https://doaj.org/article/7a5251e405c146bc825e22f84743a27f
Autor:
Seaho Kim, CheukMan C Au, Mohd Azrin Bin Jamalruddin, Naira Essam Abou-Ghali, Eiman Mukhtar, Luigi Portella, Adeline Berger, Daniel Worroll, Prerna Vatsa, David S Rickman, David M Nanus, Paraskevi Giannakakou
Publikováno v:
eLife, Vol 11 (2022)
Expression of the AR splice variant, androgen receptor variant 7 (AR-V7), in prostate cancer is correlated with poor patient survival and resistance to AR targeted therapies and taxanes. Currently, there is no specific inhibitor of AR-V7, while the m
Externí odkaz:
https://doaj.org/article/2dbc4df1b5624c61b2a0b3917507799c
Autor:
Nicola Normanno, Fabiana Tatangelo, Piera Maiolino, Stefania Scala, Caterina Ieranò, Dario Righelli, Crescenzo D'Alterio, Maria Napolitano, Luigi Portella, Giuseppina Rea, Federica Auletta, Sara Santagata, Anna Maria Trotta, Giuseppe Guardascione, Federica Liotti, Nella Prevete, Antonio Luciano, Antonio Barbieri, Annabella Di Mauro, Cristin Roma, Riziero Esposito Abate, Roberto Pacelli, Rosa Marina Melillo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Colorectal cancer (CRC) is one of the most prevalent and deadly tumors worldwide. The majority of CRC is resistant to anti-programmed cell death-1 (PD-1)-based cancer immunotherapy, with approximately 15% with high-microsatellite instabili
Externí odkaz:
https://doaj.org/article/b1c66c6327b04eacbccc9f2e0878a6d9
Autor:
Crescenzo D’Alterio, Alessandro Giardino, Giosuè Scognamiglio, Giovanni Butturini, Luigi Portella, Giuseppe Guardascione, Isabella Frigerio, Marco Montella, Stefano Gobbo, Guido Martignoni, Vincenzo Napolitano, Ferdinando De Vita, Fabiana Tatangelo, Renato Franco, Stefania Scala
Publikováno v:
Cells, Vol 11, Iss 21, p 3340 (2022)
Pancreatic ductal adenocarcinoma (PDAC) is currently the most deadly cancer. Although characterized by 5–20% of neoplastic cells in the highly fibrotic stroma, immunotherapy is not a valid option in PDAC treatment. As CXCR4-CXCL12 regulates tumor i
Externí odkaz:
https://doaj.org/article/fe998c8283b640b7a26ea9b6fe3ab49c
Autor:
Crescenzo D’Alterio, Maria Buoncervello, Caterina Ieranò, Maria Napolitano, Luigi Portella, Giuseppina Rea, Antonio Barbieri, Antonio Luciano, Giosuè Scognamiglio, Fabiana Tatangelo, Anna Maria Anniciello, Mario Monaco, Ernesta Cavalcanti, Piera Maiolino, Giulia Romagnoli, Claudio Arra, Gerardo Botti, Lucia Gabriele, Stefania Scala
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-13 (2019)
Abstract Background Inefficient T-cell access to the tumor microenvironment (TME) is among the causes of tumor immune-resistance. Previous evidence demonstrated that targeting CXCR4 improves anti-PD-1/PD-L1 efficacy reshaping TME. To evaluate the rol
Externí odkaz:
https://doaj.org/article/255e50d477da4feeaebb3e1987018bd9
Autor:
Alessandro Ottaiano, Stefania Scala, Nicola Normanno, Maria Napolitano, Monica Capozzi, Anna Maria Rachiglio, Cristin Roma, Anna Maria Trotta, Crescenzo D’Alterio, Luigi Portella, Carmela Romano, Antonino Cassata, Rossana Casaretti, Lucrezia Silvestro, Anna Nappi, Salvatore Tafuto, Antonio Avallone, Alfonso De Stefano, Mario Tamburini, Carmine Picone, Antonella Petrillo, Francesco Izzo, Raffaele Palaia, Vittorio Albino, Alfonso Amore, Andrea Belli, Ugo Pace, Massimiliano Di Marzo, Paolo Chiodini, Gerardo Botti, Gianfranco De Feo, Paolo Delrio, Guglielmo Nasti
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-9 (2019)
Abstract Background Combination of chemotherapies (fluoropirimidines, oxaliplatin and irinotecan) with biologic drugs (bevacizumab, panitumumab, cetuximab) have improved clinical responses and survival of metastatic colorectal cancer (mCRC). However,
Externí odkaz:
https://doaj.org/article/c63b96d6390c4ab8b86f568154c6b5fd
Autor:
Stefano Tomassi, Caterina Ieranò, Alessandra Del Bene, Antonia D’Aniello, Maria Napolitano, Giuseppina Rea, Federica Auletta, Luigi Portella, Anna Capiluongo, Vincenzo Mazzarella, Rosita Russo, Angela Chambery, Stefania Scala, Salvatore Di Maro, Anna Messere
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8504 (2022)
Synthetic nucleic acid interactors represent an exciting research field due to their biotechnological and potential therapeutic applications. The translation of these molecules into drugs is a long and difficult process that justifies the continuous
Externí odkaz:
https://doaj.org/article/a1c898879a9b4636bdf419a2db14e34e
Autor:
Alessandro Ottaiano, Stefania Scala, Mariachiara Santorsola, Anna Maria Trotta, Crescenzo D’Alterio, Luigi Portella, Ottavia Clemente, Anna Nappi, Nicoletta Zanaletti, Alfonso De Stefano, Antonio Avallone, Vincenza Granata, Carmen Notariello, Amalia Luce, Angela Lombardi, Carmine Picone, Antonella Petrillo, Francesco Perri, Fabiana Tatangelo, Annabella Di Mauro, Vittorio Albino, Francesco Izzo, Daniela Rega, Ugo Pace, Massimiliano Di Marzo, Paolo Chiodini, Gianfranco De Feo, Paola Del Prete, Gerardo Botti, Paolo Delrio, Michele Caraglia, Guglielmo Nasti
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Background: The intensive study of predictive factors has strongly ameliorated the therapeutic flow-chart of metastatic colorectal cancer (mCRC) by allowing the selection of patients who benefit from specific therapies. For instance, in mRAS (mutated
Externí odkaz:
https://doaj.org/article/b9abc8afe3f3424ea7cccc9a5c058f0d
Autor:
Sara Santagata, Luigi Portella, Maria Napolitano, Adelaide Greco, Crescenzo D’Alterio, Maria Vittoria Barone, Antonio Luciano, Matteo Gramanzini, Luigi Auletta, Claudio Arra, Antonella Zannetti, Stefania Scala
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract C-X-C chemokine receptor 4 (CXCR4) is over-expressed in multiple human cancers and correlates with tumor aggressiveness, poor prognosis and increased risk for distant metastases. Imaging agents for CXCR4 are thus highly desirable. We develop
Externí odkaz:
https://doaj.org/article/2e67fe00267c494d87da49165cfcd85e
Autor:
Sara Santagata, Giuseppina Rea, Daniela Castaldo, Maria Napolitano, Anna Capiluongo, Crescenzo D’Alterio, Anna Maria Trotta, Caterina Ieranò, Luigi Portella, Salvatore Di Maro, Fabiana Tatangelo, Vittorio Albino, Rita Guarino, Carmen Cutolo, Francesco Izzo, Stefania Scala
Publikováno v:
Hepatology International.
Background and purpose While HCC is an inflammation-associated cancer, CRLM develops on permissive healthy liver microenvironment. To evaluate the immune aspects of these two different environments, peripheral blood-(PB), peritumoral-(PT) and tumoral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::925d4e76fef5e1aac5e076566f5a4bbe
https://doi.org/10.1007/s12072-023-10537-6
https://doi.org/10.1007/s12072-023-10537-6