Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Luigi, Leanza"'
Autor:
Sabrina Caporali, Alessio Butera, Alessia Ruzza, Carlotta Zampieri, Marina Bantula’, Sandra Scharsich, Anna-Katerina Ückert, Ivana Celardo, Ian U. Kouzel, Luigi Leanza, Andreas Gruber, Joan Montero, Angelo D’Alessandro, Thomas Brunner, Marcel Leist, Ivano Amelio
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Background Approximately half of all human cancers harbour mutations in the p53 gene, leading to the generation of neomorphic p53 mutant proteins. These mutants can exert gain-of-function (GOF) effects, potentially promoting tumour progressi
Externí odkaz:
https://doaj.org/article/2c9b386036f84eaf9c888f23c8e8570a
Autor:
Davide Doni, Federica Cavion, Marco Bortolus, Elisa Baschiera, Silvia Muccioli, Giulia Tombesi, Federica d’Ettorre, Daniele Ottaviani, Elena Marchesan, Luigi Leanza, Elisa Greggio, Elena Ziviani, Antonella Russo, Milena Bellin, Geppo Sartori, Donatella Carbonera, Leonardo Salviati, Paola Costantini
Publikováno v:
Cell Death and Disease, Vol 14, Iss 12, Pp 1-14 (2023)
Abstract Friedreich ataxia (FRDA) is a rare, inherited neurodegenerative disease caused by an expanded GAA repeat in the first intron of the FXN gene, leading to transcriptional silencing and reduced expression of frataxin. Frataxin participates in t
Externí odkaz:
https://doaj.org/article/76a61328d5c945589e294fc868a27afb
Autor:
Silvia Muccioli, Valentina Brillo, Tatiana Varanita, Federica Rossin, Elisabetta Zaltron, Angelo Velle, Giorgia Alessio, Beatrice Angi, Filippo Severin, Anna Tosi, Manuela D’Eletto, Luca Occhigrossi, Laura Falasca, Vanessa Checchetto, Roberto Ciaccio, Amelia Fascì, Leonardo Chieregato, Ana Paula Rebelo, Marta Giacomello, Antonio Rosato, Ildikò Szabò, Chiara Romualdi, Mauro Piacentini, Luigi Leanza
Publikováno v:
Cell Death and Disease, Vol 14, Iss 10, Pp 1-19 (2023)
Abstract Skin cutaneous melanoma (SKCM) is the deadliest form of skin cancer due to its high heterogeneity that drives tumor aggressiveness. Melanoma plasticity consists of two distinct phenotypic states that co-exist in the tumor niche, the prolifer
Externí odkaz:
https://doaj.org/article/79f0270d8d5b40fca94ccccabca3556a
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Ion channels are key signaling proteins found throughout the body; they are critical in many, wide-ranging physiological processes, from gene expression, sensory perception and processing to the cardiac action potential. When ion channel activity goe
Externí odkaz:
https://doaj.org/article/d02b4945741346e0bf6751056a0542e2
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Tissue Transglutaminases (TGs) are crosslinking enzymes with pleiotropic functions that have been linked to the development and progression of numerous cancers, with a recent focus on their ability to remodel the tumor microenvironment. Alth
Externí odkaz:
https://doaj.org/article/f6e99b81d0934bc28911d5a72ca608b1
Autor:
Davide Doni, Federica Cavion, Marco Bortolus, Elisa Baschiera, Silvia Muccioli, Giulia Tombesi, Federica d’Ettorre, Daniele Ottaviani, Elena Marchesan, Luigi Leanza, Elisa Greggio, Elena Ziviani, Antonella Russo, Milena Bellin, Geppo Sartori, Donatella Carbonera, Leonardo Salviati, Paola Costantini
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f4c0c8a288f342e9aea39235d018dedc
Autor:
Filippo Severin, Andrea Urbani, Tatiana Varanita, Magdalena Bachmann, Michele Azzolini, Veronica Martini, Marco Pizzi, Angelo Paolo Dei Tos, Federica Frezzato, Andrea Mattarei, Paolo Ghia, Maria Teresa Sabrina Bertilaccio, Erich Gulbins, Cristina Paradisi, Mario Zoratti, Gianpietro Carlo Semenzato, Luigi Leanza, Livio Trentin, Ildiko Szabò
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Abstract Background Ion channels are emerging as promising oncological targets. The potassium channels Kv1.3 and IKCa are highly expressed in the plasma membrane and mitochondria of human chronic lymphocytic leukemia (CLL) cells, compared to healthy
Externí odkaz:
https://doaj.org/article/9647adfd9b38418391759ec3eeef8c34
Autor:
Elisabeth Weyandt, Luigi Leanza, Riccardo Capelli, Giovanni M. Pavan, Ghislaine Vantomme, E. W. Meijer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Controlling multicomponent systems is difficult due to convoluted behavior, pathway complexity, and coupled equilibria. Here the authors showed modulation of aggregate morphology in a zinc porphyrin-based supramolecular system via judicious capping w
Externí odkaz:
https://doaj.org/article/a1f7b7e18dd74df49fc6524a4a230b13
Autor:
Roberta Peruzzo, Samantha Corrà, Roberto Costa, Michele Brischigliaro, Tatiana Varanita, Lucia Biasutto, Chiara Rampazzo, Daniele Ghezzi, Luigi Leanza, Mario Zoratti, Massimo Zeviani, Cristiano De Pittà, Carlo Viscomi, Rodolfo Costa, Ildikò Szabò
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Mitochondrial diseases, including those caused by defects in complex III of the respiratory chain, lack curative treatments. Here the authors report that the small molecule pyocyanin has beneficial effects in cells derived from patients with complex
Externí odkaz:
https://doaj.org/article/43a9b3426f6b484aad43fa64d8021ac2
Autor:
Federica Rossin, Roberto Costa, Matteo Bordi, Manuela D’Eletto, Luca Occhigrossi, Maria Grazia Farrace, Nickolai Barlev, Fabiola Ciccosanti, Silvia Muccioli, Leonardo Chieregato, Ildiko Szabo, Gian Maria Fimia, Mauro Piacentini, Luigi Leanza
Publikováno v:
Cell Death and Disease, Vol 12, Iss 3, Pp 1-13 (2021)
Abstract TG2 is a multifunctional enzyme involved in several cellular processes and has emerging as a potential regulator of gene expression. In this regard, we have recently shown that TG2 is able to activate HSF1, the master transcriptional regulat
Externí odkaz:
https://doaj.org/article/266616b6e9a246dba598ea758ad22616