Trackins (Trk-Targeting Drugs): A Novel Therapy for Different Diseases

Autor: George N. Chaldakov, Luigi Aloe, Stanislav G. Yanev, Marco Fiore, Anton B. Tonchev, Manlio Vinciguerra, Nikolai T. Evtimov, Peter Ghenev, Krikor Dikranian

Publikováno v: Pharmaceuticals, Vol 17, Iss 7, p 961 (2024)

Many routes may lead to the transition from a healthy to a diseased phenotype. However, there are not so many routes to travel in the opposite direction; that is, therapy for different diseases. The following pressing question thus remains: what are

Externí odkaz: https://doaj.org/article/e528d37e1f31482dafc8ff3f416bb83d

'Combo' Multi-Target Pharmacological Therapy and New Formulations to Reduce Inflammation and Improve Endogenous Remyelination in Traumatic Spinal Cord Injury

Autor: Marzia Moretti, Riccardo Caraffi, Luca Lorenzini, Ilaria Ottonelli, Michele Sannia, Giuseppe Alastra, Vito Antonio Baldassarro, Alessandro Giuliani, Jason Thomas Duskey, Maura Cescatti, Barbara Ruozi, Luigi Aloe, Maria Angela Vandelli, Luciana Giardino, Giovanni Tosi, Laura Calzà

Publikováno v: Cells, Vol 12, Iss 9, p 1331 (2023)

Spinal cord injury (SCI) is characterized by a cascade of events that lead to sensory and motor disabilities. To date, this condition is irreversible, and no cure exists. To improve myelin repair and limit secondary degeneration, we developed a multi

Externí odkaz: https://doaj.org/article/59aa99aac00f4692af8891a3ebe9739f

Nerve Growth Factor Biodelivery: A Limiting Step in Moving Toward Extensive Clinical Application?

Autor: Giuseppe Alastra, Luigi Aloe, Vito Antonio Baldassarro, Laura Calzà, Maura Cescatti, Jason Thomas Duskey, Maria Letizia Focarete, Daria Giacomini, Luciana Giardino, Valentina Giraldi, Luca Lorenzini, Marzia Moretti, Irene Parmeggiani, Michele Sannia, Giovanni Tosi

Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)

Nerve growth factor (NGF) was the first-discovered member of the neurotrophin family, a class of bioactive molecules which exerts powerful biological effects on the CNS and other peripheral tissues, not only during development, but also during adulth

Externí odkaz: https://doaj.org/article/ec0d8d2337764f8db0f1c1dc814f5398

Homage to George E. Palade Cell Protein Secretion in Vascular Biology: Overview and Updates

Autor: Marco Fiore, George N. Chaldakov, Plamen Panayotov, Anna Kádár, Luigi Aloe, Peter I. Ghenev, Rouzha Pancheva

Publikováno v: Acta biologica (1955) 4 (2021): 31–43. doi:10.2478/abmj-2021-0004
info:cnr-pdr/source/autori:George N. Chaldakov, Luigi Aloe, Anna Kádár, Peter Ghenev, Marco Fiore, Rouzha Z. Pancheva and Plamen Panayotov/titolo:Homage to George E. Palade Cell Protein Secretion in Vascular Biology: Overview and Updates/doi:10.2478%2Fabmj-2021-0004/rivista:Acta biologica (1955)/anno:2021/pagina_da:31/pagina_a:43/intervallo_pagine:31–43/volume:4

This short overview and updates expresses our brain-and-heart homage to George Emil Palade, “the most influential cell biologist ever”. In his 1971 paper Palade wrote for Albert Claude, the founder of biological electron microscopic method: “Se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a480b5f345c636c8cd393370cfcb207
https://doi.org/10.2478/abmj-2021-0004

The pleiotropic molecule NGF regulates the in vitro properties of fibroblasts, keratinocytes, and endothelial cells: implications for wound healing

Autor: Luigi Aloe, Luciana Giardino, Natalia Gostynska, Micaela Pannella, Laura Calzà, Maria Luisa Rocco

Publikováno v: American Journal of Physiology-Cell Physiology. 318:C360-C371

Nerve growth factor (NGF) is recognized as a pleiotropic molecule, exerting a variety of biological effects on different cell types and pathophysiological conditions, and its role in tissue wound healing has been recently highlighted. However, the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87ff6cd2c9289173a5f93f26489b587
https://doi.org/10.1152/ajpcell.00180.2019