Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Luicer A, Ingasia"'
Autor:
Winnie Okore, Collins Ouma, Raphael O Okoth, Redemptah Yeda, Luicer O Ingasia, Edwin W Mwakio, Douglas O Ochora, Duncan M Wakoli, Joseph G Amwoma, Gladys C Chemwor, Jackline A Juma, Charles O Okudo, Agnes C Cheruiyot, Benjamin H Opot, Dennis Juma, Timothy E Egbo, Ben Andagalu, Amanda Roth, Edwin Kamau, Hoseah M Akala
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0298585 (2024)
Single nucleotide polymorphisms (SNPs) in the Plasmodium falciparum multi-drug resistance protein 1 (Pfmrp1) gene have previously been reported to confer resistance to Artemisinin-based Combination Therapies (ACTs) in Southeast Asia. A total of 300 s
Externí odkaz:
https://doaj.org/article/3552aaa210124c479cb095b7b88701bf
Autor:
Ben Andagalu, Pinyi Lu, Irene Onyango, Elke Bergmann-Leitner, Ruth Wasuna, Geoffrey Odhiambo, Lorna J. Chebon-Bore, Luicer A. Ingasia, Dennis W. Juma, Benjamin Opot, Agnes Cheruiyot, Redemptah Yeda, Charles Okudo, Raphael Okoth, Gladys Chemwor, Joseph Campo, Anders Wallqvist, Hoseah M. Akala, Daniel Ochiel, Bernhards Ogutu, Sidhartha Chaudhury, Edwin Kamau
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
The impact of pre-existing immunity on the efficacy of artemisinin combination therapy is largely unknown. We performed in-depth profiling of serological responses in a therapeutic efficacy study [comparing artesunate-mefloquine (ASMQ) and artemether
Externí odkaz:
https://doaj.org/article/8860f475c2f14a1a9ac4fc3bf97ccf77
Autor:
Peninah Muiruri, Denis W. Juma, Luicer A. Ingasia, Lorna J. Chebon, Benjamin Opot, Bidii S. Ngalah, Jelagat Cheruiyot, Ben Andagalu, Hoseah M. Akala, Venny C. S. Nyambati, Joseph K. Ng’ang’a, Edwin Kamau
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-12 (2018)
Abstract Background There are concerns that resistance to artemisinin-based combination therapy might emerge in Kenya and sub-Saharan Africa (SSA) in the same pattern as was with chloroquine and sulfadoxine–pyrimethamine. Single nucleotide polymorp
Externí odkaz:
https://doaj.org/article/5d8aeccd66544f9b84e14a2a193839fb
Autor:
Angela O. Achieng, Peninah Muiruri, Luicer A. Ingasia, Benjamin H. Opot, Dennis W. Juma, Redemptah Yeda, Bidii S. Ngalah, Bernhards R. Ogutu, Ben Andagalu, Hoseah M. Akala, Edwin Kamau
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 5, Iss 3, Pp 92-99 (2015)
Artemether–lumefantrine (AL) became the first-line treatment for uncomplicated malaria in Kenya in 2006. Studies have shown AL selects for SNPs in pfcrt and pfmdr1 genes in recurring parasites compared to the baseline infections. The genotypes asso
Externí odkaz:
https://doaj.org/article/abbbeff2eee247d5bab114bd5d409723
Autor:
Lorna J Chebon, Bidii S Ngalah, Luicer A Ingasia, Dennis W Juma, Peninah Muiruri, Jelagat Cheruiyot, Benjamin Opot, Emmanuel Mbuba, Mabel Imbuga, Hoseah M Akala, Wallace Bulimo, Ben Andagalu, Edwin Kamau
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162524 (2016)
Genetically determined artemisinin resistance in Plasmodium falciparum has been described in Southeast Asia. The relevance of recently described Kelch 13-propeller mutations for artemisinin resistance in Sub-Saharan Africa parasites is still unknown.
Externí odkaz:
https://doaj.org/article/56009bc8fab346629c57fb18b64960bd
Autor:
Redemptah Yeda, Luicer A Ingasia, Agnes C Cheruiyot, Charles Okudo, Lorna J Chebon, Jelagat Cheruiyot, Hoseah M Akala, Edwin Kamau
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0143565 (2016)
The Plasmodium falciparum in vitro culture system is critical for genotypic and phenotypic analyses of the parasites. For genotypic analysis, the genomic DNA can be obtained directly from the patient blood sample or from culture adapted parasites whe
Externí odkaz:
https://doaj.org/article/bd321eb9334a4710bc2d246b8bec2f2f
Autor:
Agnes C. Cheruiyot, Ruth Wasuna, Elke S. Bergmann-Leitner, Pinyi Lu, Luicer A. Ingasia, Sidhartha Chaudhury, Edwin Kamau, Redemptah Yeda, Daniel Ochiel, Geoffrey Odhiambo, Charles Okudo, Joseph J. Campo, Ben Andagalu, Hoseah M. Akala, Anders Wallqvist, Dennis W. Juma, Gladys C. Chemwor, Irene Onyango, Raphael Okoth, Benjamin Opot, Lorna J. Chebon-Bore, Bernhards Ogutu
The role of humoral immunity on the efficacy of artemisinin combination therapy (ACT) has not been investigated, yet naturally acquired immunity is key determinant of antimalarial therapeutic response. We conducted a therapeutic efficacy study in hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::887a368c9aaba7d2252a1e7af726cca3
https://doi.org/10.1101/2020.08.12.248724
https://doi.org/10.1101/2020.08.12.248724
Autor:
Luicer A. Ingasia, Zaydah R. de Laurent, Edwin Kamau, Hoseah M. Akala, Ben Andagalu, Lynette Isabella Ochola-Oyier, Lorna J. Chebon
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 98:1360-1366
The development of artemisinin (ART)-resistant parasites in Southeast Asia (SEA) threatens malaria control globally. Mutations in the Kelch 13 (K13)-propeller domain have been useful in identifying ART resistance in SEA. ART combination therapy (ACT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeb91ef8e7c7b59d37f95e78a60b5d04
https://doi.org/10.4269/ajtmh.17-0505
https://doi.org/10.4269/ajtmh.17-0505
Publikováno v:
Infection, Genetics and Evolution. 39:372-380
Transmission intensity, movement of human and vector hosts, biogeographical features, and malaria control measures are some of the important factors that determine Plasmodium falciparum parasite genetic variability and population structure. Kenya has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e066f4342d0afd9db61cb8d91c46fc44
https://doi.org/10.1016/j.meegid.2015.10.013
https://doi.org/10.1016/j.meegid.2015.10.013
Autor:
Benjamin Opot, Denis W. Juma, Peninah Muiruri, Luicer A. Ingasia, Jelagat Cheruiyot, Lorna J. Chebon, Joseph K. Ng’ang’a, Hoseah M. Akala, Edwin Kamau, Venny C. S. Nyambati, Bidii S. Ngalah, Ben Andagalu
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-12 (2018)
Malaria Journal
Malaria Journal
Background There are concerns that resistance to artemisinin-based combination therapy might emerge in Kenya and sub-Saharan Africa (SSA) in the same pattern as was with chloroquine and sulfadoxine–pyrimethamine. Single nucleotide polymorphisms (SN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01560b976ba05dec7908b2c014459e3f
https://doi.org/10.1186/s12936-018-2534-8
https://doi.org/10.1186/s12936-018-2534-8