Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Luhui Shen"'
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Purpose To evaluate a new class of blood-based biomarkers, anti-frameshift peptide antibodies, for predicting both tumor responses and adverse immune events to immune checkpoint inhibitor (ICI) therapies in advanced lung cancer patients. Exp
Externí odkaz:
https://doaj.org/article/93e22905aa9e4ceaa5ae5045789ad2b5
Autor:
Milene Peterson, Sierra Nicole Murphy, John Lainson, Jian Zhang, Luhui Shen, Chris W. Diehnelt, Stephen Albert Johnston
Publikováno v:
BMC Immunology, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background It is widely hoped that personal cancer vaccines will extend the number of patients benefiting from checkpoint and other immunotherapies. However, it is clear creating such vaccines will be challenging. It requires obtaining and s
Externí odkaz:
https://doaj.org/article/f77f6689e82640a88f053e42321002b6
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157462 (2016)
Antigen-antibody complexes are central players in an effective immune response. However, finding those interactions relevant to a particular disease state can be arduous. Nonetheless many paths to discovery have been explored since deciphering these
Externí odkaz:
https://doaj.org/article/2117021cecb34ed7bbca7a312d120e6a
Autor:
Paul E Oran, Olgica Trenchevska, Dobrin Nedelkov, Chad R Borges, Matthew R Schaab, Douglas S Rehder, Jason W Jarvis, Nisha D Sherma, Luhui Shen, Bryan Krastins, Dawn C Schwenke, Peter D Reaven, Randall W Nelson
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92801 (2014)
Insulin-like growth factor 1 (IGF1) is an important biomarker for the management of growth hormone disorders. Recently there has been rising interest in deploying mass spectrometric (MS) methods of detection for measuring IGF1. However, widespread cl
Externí odkaz:
https://doaj.org/article/bb85b97f782f4818917849d3347eec55
Autor:
Stephen Albert Johnston, John C. Lainson, Zhan Gong Zhao, Kathryn Sykes, Chris W. Diehnelt, Luhui Shen, Justin R. Brown
Publikováno v:
RSC Advances. 10:29675-29681
Parallel measurement of large numbers of antigen–antibody interactions are increasingly enabled by peptide microarray technologies. Our group has developed an in situ synthesized peptide microarray of >400 000 frameshift neoantigens using mask-base
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
The success of checkpoint inhibitors in cancer therapy is largely attributed to activating the patient’s immune response to their tumor’s neoantigens arising from DNA mutations. This realization has motivated the interest in personal cancer vacci
Autor:
Milene Peterson, Murphy, Sierra Nicole, Lainson, John, Zhang, Jian, Luhui Shen, Diehnelt, Chris W., Johnston, Stephen Albert
Additional file 2 Supplementary Fig. 1. Heat map of the FS peptides selected for the NR-PCV vaccine groups. Y-axis, FS peptides; X-axis = mouse ID and time point (T0, before 4T1 challenge; T7, 7 days post challenge). Mice #ID 1 - #ID 5 were treated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19494cfc17f8b195d9cc4a027e6319b9
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
Scientific Reports, Vol 9, Iss 1, Pp 1-1 (2019)
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
Scientific Reports, Vol 9, Iss 1, Pp 1-1 (2019)
The success of checkpoint inhibitors in cancer therapy is largely attributed to activating the patient's immune response to their tumor's neoantigens arising from DNA mutations. This realization has motivated the interest in personal cancer vaccines
Autor:
Stephen Albert Johnston, Paul E. Belcher, Luhui Shen, Chris W. Diehnelt, Nidhi Gupta, Hugh S. Mason, John C. Lainson
Publikováno v:
Analytical Chemistry. 89:7174-7181
Noroviruses are the most common cause of acute gastroenteritis in the developed world. Noroviruses are a diverse group of nonenveloped RNA viruses that are continuously evolving. This leads to the rise of immunologically distinct strains of the same
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
It has been demonstrated that DNA mutations generating neo-antigens are important for an effective immune response to tumors as evident from recent clinical studies of immune checkpoint inhibitors (ICIs). Further, it was shown that frameshift peptide