Zobrazeno 1 - 10
of 704
pro vyhledávání: '"Luhua Lai"'
Autor:
Wenzhe Liu, Limin Chen, Dongbao Yin, Zhiheng Yang, Jianfei Feng, Qi Sun, Luhua Lai, Xuefeng Guo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Intrinsically disordered proteins (IDPs) play crucial roles in cellular processes and hold promise as drug targets. However, the dynamic nature of IDPs remains poorly understood. Here, we construct a single-molecule electrical nanocircuit ba
Externí odkaz:
https://doaj.org/article/98bc306d9a8d441b9438b103793c068a
Autor:
Jiawei Ding, Xiangting Li, Jiangchuan Shen, Yiling Zhao, Shuchen Zhong, Luhua Lai, Hengyao Niu, Zhi Qi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The eukaryotic single-stranded DNA (ssDNA)-binding protein Replication Protein A (RPA) plays a crucial role in various DNA metabolic pathways, including DNA replication and repair, by dynamically associating with ssDNA. While the binding of
Externí odkaz:
https://doaj.org/article/2de5301cc46545f8bc4318d4d904a728
Autor:
Lu, Yi1
Publikováno v:
Nature Chemistry. Mar2014, Vol. 6 Issue 3, p175-177. 3p.
Publikováno v:
Chemical Science; 6/7/2024, Vol. 15 Issue 21, p7926-7942, 17p
Publikováno v:
eLife, Vol 12 (2023)
Allostery is fundamental to many biological processes. Due to the distant regulation nature, how allosteric mutations, modifications, and effector binding impact protein function is difficult to forecast. In protein engineering, remote mutations cann
Externí odkaz:
https://doaj.org/article/494c05a4425545be8a974750e6e64884
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background The liquid–liquid phase separation (LLPS) of biomolecules in cell underpins the formation of membraneless organelles, which are the condensates of protein, nucleic acid, or both, and play critical roles in cellular function. Dys
Externí odkaz:
https://doaj.org/article/7a49c01f01d548a1bf5e59bdf37cc83d
Publikováno v:
Molecules, Vol 28, Iss 17, p 6430 (2023)
Although loop epitopes at protein-protein binding interfaces often play key roles in mediating oligomer formation and interaction specificity, their binding sites are underexplored as drug targets owing to their high flexibility, relatively few hot s
Externí odkaz:
https://doaj.org/article/93827ec846094b78b144014e2b3a47db
Publikováno v:
Pharmacological Research - Modern Chinese Medicine, Vol 5, Iss , Pp 100159- (2022)
Circadian clock governs a large array of physiological and metabolic functions. The amplitude decline of circadian rhythm is associated with various chronic diseases. However, few clock enhancing-molecules are known. CRY1 is one of the main component
Externí odkaz:
https://doaj.org/article/b2393823dff64ae0bfa4a74ff339a3f6
Autor:
Hongbo Liu, Fei Ye, Qi Sun, Hao Liang, Chunmei Li, Siyang Li, Roujian Lu, Baoying Huang, Wenjie Tan, Luhua Lai
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 497-503 (2021)
COVID-19 has become a global pandemic and there is an urgent call for developing drugs against the virus (SARS-CoV-2). The 3C-like protease (3CLpro) of SARS-CoV-2 is a preferred target for broad spectrum anti-coronavirus drug discovery. We studied th
Externí odkaz:
https://doaj.org/article/591504ee8ee248d5ab1114ed12786a55
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Metabolic reprogramming is one of the hallmarks of tumorigenesis. Understanding the metabolic changes in cancer cells may provide attractive therapeutic targets and new strategies for cancer therapy. The metabolic states are not the same in different
Externí odkaz:
https://doaj.org/article/6a4a3e4fd4c64de1abe7cdea8868fc00