Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy.

Autor: Luheshi, NM¹, Rothwell, NJ¹, Brough, D¹, Luheshi, N M¹ (AUTHOR), Rothwell, N J (AUTHOR)

Publikováno v: British Journal of Pharmacology. Aug2009, Vol. 157 Issue 8, p1318-1329. 12p.

Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.

Autor: Austin M; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK.; Antibody Discovery & Protein Engineering, BioPharmaceuticals R&D, AstraZeneca , Cambridge, UK., Burschowsky D; Leicester Institute of Structural and Chemical Biology and the Department of Molecular and Cell Biology, University of Leicester , Leicester, UK., Chan DTY; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK., Jenkinson L; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK., Haynes S; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK., Diamandakis A; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK., Seewooruthun C; Leicester Institute of Structural and Chemical Biology and the Department of Molecular and Cell Biology, University of Leicester , Leicester, UK., Addyman A; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK., Fiedler S; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK., Ryman S; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK., Whitehouse J; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK., Slater LH; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK., Hadjinicolaou AV; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford , Oxford, UK., Gileadi U; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford , Oxford, UK., Gowans E; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK., Shibata Y; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK., Barnard M; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK., Kaserer T; Cancer Research UK, Cancer Therapeutics Unit, The Institute of Cancer Research , London, UK., Sharma P; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK., Luheshi NM; Early Oncology Discovery, Oncology R&D, AstraZeneca , Cambridge, UK., Wilkinson RW; Early Oncology Discovery, Oncology R&D, AstraZeneca , Cambridge, UK., Vaughan TJ; Antibody Discovery & Protein Engineering, BioPharmaceuticals R&D, AstraZeneca , Cambridge, UK., Holt SV; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK., Cerundolo V; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford , Oxford, UK., Carr MD; Leicester Institute of Structural and Chemical Biology and the Department of Molecular and Cell Biology, University of Leicester , Leicester, UK., Groves MAT; Cancer Research UK AstraZeneca Antibody Alliance Laboratory , Cambridge, UK.; Antibody Discovery & Protein Engineering, BioPharmaceuticals R&D, AstraZeneca , Cambridge, UK.

Publikováno v: MAbs [MAbs] 2020 Jan-Dec; Vol. 12 (1), pp. 1801230.

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes.

Autor: Tapia VS; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9PT, United Kingdom; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, United Kingdom., Daniels MJD; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, United Kingdom; UK Dementia Research Institute, University of Edinburgh, College of Medicine and Veterinary Medicine, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, United Kingdom., Palazón-Riquelme P; Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Collaborative Centre of Inflammation Research, Manchester Academic Health Science Centre, Core Technology Facility, University of Manchester, Manchester M13 9PT, United Kingdom; International Centre for Infectiology Research, INSERM U1111, CNRS UMR5308, École Normale Supérieure de Lyon, Claude Bernard Lyon 1 University, 69100 Lyon, France., Dewhurst M; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, United Kingdom; Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Department of Biochemistry, National University of Singapore (NUS), Singapore 119007, Singapore., Luheshi NM; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, United Kingdom; MedImmune Ltd., Aaron Klug Building, Granta Park, Cambridge CB21 6GH, United Kingdom., Rivers-Auty J; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9PT, United Kingdom; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, United Kingdom., Green J; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9PT, United Kingdom; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, United Kingdom., Redondo-Castro E; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, United Kingdom., Kaldis P; Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Department of Biochemistry, National University of Singapore (NUS), Singapore 119007, Singapore., Lopez-Castejon G; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9PT, United Kingdom; Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Collaborative Centre of Inflammation Research, Manchester Academic Health Science Centre, Core Technology Facility, University of Manchester, Manchester M13 9PT, United Kingdom. Electronic address: Gloria.lopez-castejon@manchester.ac.uk., Brough D; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9PT, United Kingdom; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, United Kingdom. Electronic address: david.brough@manchester.ac.uk.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2019 May 24; Vol. 294 (21), pp. 8325-8335. Date of Electronic Publication: 2019 Apr 02.

Boron-Based Inhibitors of the NLRP3 Inflammasome.

Autor: Baldwin AG; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK., Rivers-Auty J; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK., Daniels MJD; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK., White CS; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK., Schwalbe CH; Aston Pharmacy School, School of Life & Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK., Schilling T; St. George's, University of London, Institute for Infection and Immunity, Cranmer Terrace, London SW17 0RE, UK., Hammadi H; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK., Jaiyong P; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK., Spencer NG; St. George's, University of London, Institute for Infection and Immunity, Cranmer Terrace, London SW17 0RE, UK., England H; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK., Luheshi NM; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK; MedImmune Ltd., Aaron Klug Building, Granta Park, Cambridge CB21 6GH, UK., Kadirvel M; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK., Lawrence CB; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK., Rothwell NJ; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK., Harte MK; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK., Bryce RA; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK., Allan SM; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK., Eder C; St. George's, University of London, Institute for Infection and Immunity, Cranmer Terrace, London SW17 0RE, UK., Freeman S; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK. Electronic address: sally.freeman@manchester.ac.uk., Brough D; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK. Electronic address: david.brough@manchester.ac.uk.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2017 Nov 16; Vol. 24 (11), pp. 1321-1335.e5. Date of Electronic Publication: 2017 Sep 21.

Combining cisplatin and a STING agonist into one molecule for metalloimmunotherapy of cancer.

Autor: Zhang, Shuren¹ (AUTHOR), Song, Dongfan¹ (AUTHOR), Yu, Wenhao¹ (AUTHOR), Li, Ji¹ (AUTHOR), Wang, Xiaoyu¹ (AUTHOR), Li, Yachao¹ (AUTHOR), Zhao, Zihan² (AUTHOR), Xue, Qi¹ (AUTHOR), Zhao, Jing^1,3 (AUTHOR), Li, Jie P¹ (AUTHOR) jieli@nju.edu.cn, Guo, Zijian^1,3 (AUTHOR) zguo@nju.edu.cn

Publikováno v: National Science Review. Jan2024, Vol. 11 Issue 1, p1-13. 13p.