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A first-in-class, first-in-human, phase I trial of CIGB-552, a synthetic peptide targeting COMMD1 to inhibit the oncogenic activity of NF-κB in patients with advanced solid tumors.

Autor: Vallespi MG; Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba., Mestre B; National Institute of Oncology and Radiobiology (INOR), Havana, Cuba., Marrero MA; National Coordinating Center for Clinical Trials (CENCEC), Havana, Cuba., Uranga R; National Coordinating Center for Clinical Trials (CENCEC), Havana, Cuba., Rey D; National Coordinating Center for Clinical Trials (CENCEC), Havana, Cuba., Lugiollo M; National Institute of Oncology and Radiobiology (INOR), Havana, Cuba., Betancourt M; National Institute of Oncology and Radiobiology (INOR), Havana, Cuba., Silva K; National Institute of Oncology and Radiobiology (INOR), Havana, Cuba., Corrales D; National Institute of Oncology and Radiobiology (INOR), Havana, Cuba., Lamadrid Y; National Institute of Oncology and Radiobiology (INOR), Havana, Cuba., Rodriguez Y; National Institute of Oncology and Radiobiology (INOR), Havana, Cuba., Maceo A; National Coordinating Center for Clinical Trials (CENCEC), Havana, Cuba., Chaviano PP; National Coordinating Center for Clinical Trials (CENCEC), Havana, Cuba., Lemos G; Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba., Cabrales A; Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba., Freyre FM; Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba., Santana H; Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba., Garay HE; Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba., Oliva B; Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba., Fernandez JR; Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba.

Publikováno v: International journal of cancer [Int J Cancer] 2021 Sep 15; Vol. 149 (6), pp. 1313-1321. Date of Electronic Publication: 2021 May 27.