Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Luge Li"'
Autor:
Jia Song, Jose Alberto Navarro-Garcia, Jiao Wu, Arnela Saljic, Issam Abu-Taha, Luge Li, Satadru K. Lahiri, Joshua A. Keefe, Yuriana Aguilar-Sanchez, Oliver M. Moore, Yue Yuan, Xiaolei Wang, Markus Kamler, William E. Mitch, Gema Ruiz-Hurtado, Zhaoyong Hu, Sandhya S. Thomas, Dobromir Dobrev, Xander H.T. Wehrens, Na Li
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Chronic kidney disease (CKD) is associated with a higher risk of atrial fibrillation (AF). The mechanistic link between CKD and AF remains elusive. IL-1β, a main effector of NLR family pyrin domain–containing 3 (NLRP3) inflammasome activation, is
Externí odkaz:
https://doaj.org/article/7058a42f3d504f2f9a85c2061605f1cd
Autor:
Hua Mao, Luge Li, Qiying Fan, Aude Angelini, Pradip K. Saha, Cristian Coarfa, Kimal Rajapakshe, Dimuthu Perera, Jizhong Cheng, Huaizhu Wu, Christie M. Ballantyne, Zheng Sun, Liang Xie, Xinchun Pi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The vascular endothelium contributes to metabolic regulation, however, the underlying mechanisms are not fully understood. Here the authors show that endothelial low-density lipoprotein receptor-related protein 1 regulates glucose homeostasis via ost
Externí odkaz:
https://doaj.org/article/2bb6c637cb5f4e2eb55a2f359b4beb74
Autor:
Nicole Prodan, Faheem Ershad, Arfaxad Reyes-Alcaraz, Luge Li, Brandon Mistretta, Lei Gonzalez, Zhoulyu Rao, Cunjiang Yu, Preethi H. Gunaratne, Na Li, Robert J. Schwartz, Bradley K. McConnell
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105402- (2022)
Summary: Currently, there are no treatments that ameliorate cardiac cell death, the underlying basis of cardiovascular disease. An unexplored cell type in cardiac regeneration is cardiac Purkinje cells; specialized cells from the cardiac conduction s
Externí odkaz:
https://doaj.org/article/4c481036b7274d13bdf13ca5affea25f
Autor:
Hua Mao, Luge Li, Qiying Fan, Aude Angelini, Pradip K. Saha, Huaizhu Wu, Christie M. Ballantyne, Sean M. Hartig, Liang Xie, Xinchun Pi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Type 2 diabetes is associated with chronic inflammation and is characterized by insulin resistance. Here, the authors identify a crucial role for endothelial BMPER function in glucose homeostasis, and BMPER overexpression was shown to alleviate insul
Externí odkaz:
https://doaj.org/article/955957e083474c468a00c6e9258ec4a1
Autor:
Hua Mao, Pamela Lockyer, Luge Li, Christie M. Ballantyne, Cam Patterson, Liang Xie, Xinchun Pi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
LDL receptor-related protein 1 (LRP1) is an endocytic receptor involved in cell signalling and energy homeostasis. Here Maoet al. demonstrate that endothelial Lrp1 modulates lipid and glucose metabolism by binding the nuclear receptor Pparγ and prom
Externí odkaz:
https://doaj.org/article/9568598d8eac4446926e96a6f3554058
Autor:
Luge Li, Cristian Coarfa, Yue Yuan, Issam Abu-Taha, Xiaolei Wang, Jia Song, Amrit Koirala, Sandra L Grimm, Markus Kamler, Lisa K Mullany, Michelle Tallquist, Stanley Nattel, Dobromir Dobrev, Na Li
Publikováno v:
bioRxiv
BackgroundRecent work has shown that the NLR-family-pyrin-domain-containing 3 (NLRP3) inflammasome is expressed in cardiomyocytes and when specifically activated causes atrial electrical remodeling and arrhythmogenicity. Whether the NLRP3-inflammasom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06999ef25d868ed1d982a9931b3ca90f
https://europepmc.org/articles/PMC10245773/
https://europepmc.org/articles/PMC10245773/
Autor:
Xiaolei Wang, Jia Song, Yue Yuan, Luge Li, Issam Abu-Taha, Jordi Heijman, Liang Sun, Shokoufeh Dobrev, Markus Kamler, Liang Xie, Xander H.T. Wehrens, Frank T. Horrigan, Dobromir Dobrev, Na Li
Publikováno v:
Circulation Research.
Background: Atrial fibrillation (AF), the most common arrhythmia, is associated with the downregulation of FKBP5 (encoding FKBP5 [FK506 binding protein 5]). However, the function of FKBP5 in the heart remains unknown. Here, we elucidate the consequen
Autor:
Xinchun Pi, Liang Xie, Sean M. Hartig, Huaizhu Wu, Pradip K. Saha, Aude Angelini, Qiying Fan, Hua Mao, Luge Li, Christie M. Ballantyne
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications
Accumulating evidence suggests that chronic inflammation of metabolic tissues plays a causal role in obesity-induced insulin resistance. Yet, how specific endothelial factors impact metabolic tissues remains undefined. Bone morphogenetic protein (BMP
Autor:
Dobromir Dobrev, Na Li, Jilu Lang, Xiaolei Wang, Prashanthan Sanders, Larry D. Scott, George E. Taffet, Anke C. Fender, Darragh Twomey, Rodrigo Diaz-Lankenau, Markus Kamler, Mathias Hohl, Thuy T. Pham, Dominik Linz, Xiaohui Chen, Arnela Saljic, Mark L. Entman, Mihail G. Chelu, Luge Li
Publikováno v:
Cardiovascular Research, 117(7), 1746-1759. Oxford University Press
Cardiovasc Res
Cardiovasc Res
Aims Obesity, an established risk factor of atrial fibrillation (AF), is frequently associated with enhanced inflammatory response. However, whether inflammatory signaling is causally linked to AF pathogenesis in obesity remains elusive. We recently
Autor:
Jizhong Cheng, Christie M. Ballantyne, Luge Li, Xinchun Pi, Hua Mao, Dimuthu Perera, Zheng Sun, Liang Xie, Pradip K. Saha, Huaizhu Wu, Cristian Coarfa, Kimal Rajapakshe, Aude Angelini, Qiying Fan
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The vascular endothelium is present within metabolic organs and actively regulates energy metabolism. Here we show osteocalcin, recognized as a bone-secreted metabolic hormone, is expressed in mouse primary endothelial cells isolated from heart, lung