Zobrazeno 1 - 10 of 90 pro vyhledávání: '"Lugar CW"'
1
Akademický článek
Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt).
Autor: Lugar CW; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Clarke CA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Morphy R; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Rudyk H; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Sapmaz S; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Stites RE; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Vaught GM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Furness K; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Broughton HB; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Durst GL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Clawson DK; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Stout SL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Guo SY; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Durbin JD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Stayrook KR; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Edmondson DD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Kikly K; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., New NE; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Bina HA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Chambers MG; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Shetler P; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Chang WY; Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California 92121, United States., Chang VC; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Barr R; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Gough WH; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Steele JP; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Getman B; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Patel N; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Mathes BM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Richardson TI; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 5470-5484. Date of Electronic Publication: 2021 Apr 14.
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2
Structure-activity relationships of selective estrogen receptor modulators: modifications to the 2-arylbenzothiophene core of raloxifene
Autor: Don Richard Finley, Andrew L. Glasebrook, Ellen R. Rowley, Lorri L. Short, Adrian, Martin Michael John, Magee David Edward, David Lynn Phillips, Lewis D. Pennington, Lugar Cw rd, Sung-Yong Stephen Cho, Mark A. Winter, Ken Matsumoto, Harlan W. Cole, Bryant Hu, Timothy Alan Grese, Charles David Jones, Godfrey Ag
Publikováno v: Journal of medicinal chemistry. 40(2)
The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator which is currently under clinical evaluation for the prevention and treatment of postmenopausal osteoporosis. A series of raloxifene analogs which contain modification
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82509c0f3ab244dea00fd753c3fcecf
https://pubmed.ncbi.nlm.nih.gov/9003514
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3
Akademický článek
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4
Akademický článek
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5
Akademický článek
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6
Akademický článek
Novel 3-aryl indoles as progesterone receptor antagonists for uterine fibroids.
Autor: Richardson TI; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Clarke CA; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Yu KL; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Yee YK; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Bleisch TJ; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Lopez JE; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Jones SA; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Hughes NE; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Muehl BS; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Lugar CW; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Moore TL; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Shetler PK; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Zink RW; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Osborne JJ; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Montrose-Rafizadeh C; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Patel N; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Geiser AG; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Galvin RJ; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Dodge JA; Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2010 Dec 09; Vol. 2 (2), pp. 148-53. Date of Electronic Publication: 2010 Dec 09 (Print Publication: 2011).
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7
Akademický článek
Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 2: structure-activity relationship studies on the benzopyran scaffold.
Autor: Richardson TI; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. t_richardson@lilly.com , Norman BH, Lugar CW, Jones SA, Wang Y, Durbin JD, Krishnan V, Dodge JA
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Jul 01; Vol. 17 (13), pp. 3570-4. Date of Electronic Publication: 2007 Apr 25.
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8
Akademický článek
Benzopyrans are selective estrogen receptor beta agonists with novel activity in models of benign prostatic hyperplasia.
Autor: Norman BH; Discovery Chemistry Research, Bone and Inflammation Research, Lead Optimization Biology, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA. norman@lilly.com, Dodge JA, Richardson TI, Borromeo PS, Lugar CW, Jones SA, Chen K, Wang Y, Durst GL, Barr RJ, Montrose-Rafizadeh C, Osborne HE, Amos RM, Guo S, Boodhoo A, Krishnan V
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2006 Oct 19; Vol. 49 (21), pp. 6155-7.
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9
Akademický článek
Evaluation of the major metabolites of raloxifene as modulators of tissue selectivity.
Autor: Dodge JA; Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, U.S.A., Lugar CW, Cho S, Short LL, Sato M, Yang NN, Spangle LA, Martin MJ, Phillips DL, Glasebrook AL, Osborne JJ, Frolik CA, Bryant HU
Publikováno v: The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 1997 Apr; Vol. 61 (1-2), pp. 97-106.
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10
Akademický článek
Structure-activity relationships of selective estrogen receptor modulators: modifications to the 2-arylbenzothiophene core of raloxifene.
Autor: Grese TA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA., Cho S, Finley DR, Godfrey AG, Jones CD, Lugar CW 3rd, Martin MJ, Matsumoto K, Pennington LD, Winter MA, Adrian MD, Cole HW, Magee DE, Phillips DL, Rowley ER, Short LL, Glasebrook AL, Bryant HU
Publikováno v: Journal of medicinal chemistry [J Med Chem] 1997 Jan 17; Vol. 40 (2), pp. 146-67.
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