Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Lufei Hu"'
Autor:
Lufei Hu, Yinhong Chen, Xiaoyan Zhou, Maarten Hoek, Jason Cox, Ken Lin, Yang Liu, Wendy Blumenschein, Jeff Grein, Gayathri Swaminath
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0261000 (2022)
BackgroundDiabetic nephropathy is associated with endothelial dysfunction and oxidative stress, in which the nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling pathway is impaired. We hypothesize that sGC st
Externí odkaz:
https://doaj.org/article/d4b857f36f2440988e46294fa3b9ff3e
Autor:
Richard Johnstone, Zhao Ren, Myung K. Shin, Maarten Hoek, Haihong Zhou, Anthony Kreamer, Mary-Jo Wildey, Jason E. Imbriglio, Stephen F. Previs, Xi Ai, Andrea M. Peier, Steve Cifelli, Lufei Hu, Ashmita Saigal, Josephine Johnson, Richard Visconti, Yanqing Kan, Lin-Lin Shiao, William T. McElroy, Jonathan W. Choy, Adam B. Weinglass, Ying Lei, Robert Ramos, Andy Liaw, Michelle Chen
Publikováno v:
SLAS Discovery. 26:1225-1237
High-throughput phenotypic screening is a key driver for the identification of novel chemical matter in drug discovery for challenging targets, especially for those with an unclear mechanism of pathology. For toxic or gain-of-function proteins, small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4441c7993243e64c0eaf4458d6e4f2
https://doi.org/10.1177/24725552211026245
https://doi.org/10.1177/24725552211026245
Autor:
Eric Messina, Marie A. Holahan, Lufei Hu, Xiaoyan Zhou, Gayathri Swaminath, Catherine D. G. Hines, Fuqiang Zhao
Publikováno v:
NMR in Biomedicine. 34
Kidney diseases such as acute kidney injury, diabetic nephropathy and chronic kidney disease (CKD) are related to dysfunctions of the microvasculature in the kidney causing a decrease in renal blood perfusion (RBP). Pharmacological intervention to im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6dd549d5a0126f6a0d2b316fe917afa
https://doi.org/10.1002/nbm.4566
https://doi.org/10.1002/nbm.4566
Autor:
Elfatih Elzein, Cindy Hong Li, Daniel Soohoo, Britton Kenneth Corkey, Chandru Venkataramani, Xiao-Jun Li, Manoj C. Desai, Nesrine El-Bizri, Haibo Jiang, Kobayashi Tetsuya, Nevena Mollova, Sridharan Rajamani, Jason K. Perry, Arvinder Dhalla, Thao Perry, Xiaofen Li, Robert G. Strickley, Notte Gregory, Gerry Rhodes, Ryoko Hirakawa, Luiz Belardinelli, Eve-Irene Lepist, Parkhill Eric Q, Jeff Zablocki, Oliver L. Saunders, Lu Yafan, Rao Kalla, Dmitry Koltun, Cheng Xie, Gongxin Liu, Wei-Qun Wang, Kris M. Kahlig, Bernard P. Murray, Michael Graupe, Guerrero Juan A, Martinez Ruben, Mark Osier, Lufei Hu
Publikováno v:
Journal of Medicinal Chemistry. 59:9005-9017
Late sodium current (late INa) is enhanced during ischemia by reactive oxygen species (ROS) modifying the Nav 1.5 channel, resulting in incomplete inactivation. Compound 4 (GS-6615, eleclazine) a novel, potent, and selective inhibitor of late INa, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d94b0c7942e17b573ee6f2bc8434003
https://doi.org/10.1021/acs.jmedchem.6b00939
https://doi.org/10.1021/acs.jmedchem.6b00939
Autor:
Jeff A, Zablocki, Elfatih, Elzein, Xiaofen, Li, Dmitry O, Koltun, Eric Q, Parkhill, Tetsuya, Kobayashi, Ruben, Martinez, Britton, Corkey, Haibo, Jiang, Thao, Perry, Rao, Kalla, Gregory T, Notte, Oliver, Saunders, Michael, Graupe, Yafan, Lu, Chandru, Venkataramani, Juan, Guerrero, Jason, Perry, Mark, Osier, Robert, Strickley, Gongxin, Liu, Wei-Qun, Wang, Lufei, Hu, Xiao-Jun, Li, Nesrine, El-Bizri, Ryoko, Hirakawa, Kris, Kahlig, Cheng, Xie, Cindy Hong, Li, Arvinder K, Dhalla, Sridharan, Rajamani, Nevena, Mollova, Daniel, Soohoo, Eve-Irene, Lepist, Bernard, Murray, Gerry, Rhodes, Luiz, Belardinelli, Manoj C, Desai
Publikováno v:
Journal of medicinal chemistry. 59(19)
Late sodium current (late I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42002de8c78a8f6b8aa2978518cc834f
https://pubmed.ncbi.nlm.nih.gov/27690427
https://pubmed.ncbi.nlm.nih.gov/27690427
Autor:
Serge Karpinski, Sridharan Rajamani, Dmitry Koltun, Wei-Qun Wang, Cathy Smith-Maxwell, Nesrine El-Bizri, Lina Yao, William J. Crumb, Xiao-Jun Li, John C. Shryock, Arvinder Dhalla, Luiz Belardinelli, Lufei Hu, Cindy Hong Li, Gongxin Liu, Ryoko Hirakawa, Lin Wu, Jeff Zablocki
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 344:23-32
Inhibition of cardiac late sodium current (late I(Na)) is a strategy to suppress arrhythmias and sodium-dependent calcium overload associated with myocardial ischemia and heart failure. Current inhibitors of late I(Na) are unselective and can be proa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8baa8f90713bb06ec124c0e561de524c
https://doi.org/10.1124/jpet.112.198887
https://doi.org/10.1124/jpet.112.198887
Publikováno v:
American Journal of Physiology-Renal Physiology. 299:F280-F283
Conventional indicator dilution techniques for measuring body fluid volume are laborious, expensive, and highly invasive. Bioimpedance spectroscopy (BIS) may be a useful alternative due to being rapid, minimally invasive, and allowing repeated measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327c24ac4c670f24c9f9384d9cae1191
https://doi.org/10.1152/ajprenal.00113.2010
https://doi.org/10.1152/ajprenal.00113.2010
Autor:
Lufei Hu, Rong Chen, Daniel F. Catanzaro, Ying Zhou, Yuexian Shi, John H. Laragh, Jean E. Sealey, Carmen Merali
Publikováno v:
American Journal of Hypertension. 17:395-403
Because nitric oxide may attenuate both the pressor and cytotoxic effects of angiotensin II (Ang II), we investigated whether nitric oxide synthase (NOS) inhibition might accelerate the slow pressor effect of Ang II, and augment target organ damage.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0bd68d4b1ef9a2dec9e3e29b91d6aea
https://doi.org/10.1016/j.amjhyper.2004.01.003
https://doi.org/10.1016/j.amjhyper.2004.01.003
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 21, Iss S9, Pp 1-12 (2021)
Abstract Background Clinical notes are unstructured text documents generated by clinicians during patient encounters, generally are annotated with International Classification of Diseases (ICD) codes, which give formatted information about the diagno
Externí odkaz:
https://doaj.org/article/3fa31aee624647a9993899b1ea411720
Autor:
R. Davis Manning, Lufei Hu
Publikováno v:
American Journal of Hypertension. 11:328-339
A previous study in conscious dogs showed that the normal hypertensive response to short-term nitric oxide synthesis inhibition was markedly attenuated during angiotensin II-AT1 receptor inhibition. However, whether angiotensin plays an important car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc97e90a79dc3a902e4d0db7dd59710
https://doi.org/10.1016/s0895-7061(97)00418-4
https://doi.org/10.1016/s0895-7061(97)00418-4