Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Luena Papa"'
Autor:
Maria Feola, Andrea Zamperone, Daniel Moskop, Huiyong Chen, Carla Casu, Dechen Lama, Julie Di Martino, Mansour Djedaini, Luena Papa, Marc Ruiz Martinez, Tenzin Choesang, Jose Javier Bravo-Cordero, Matthew MacKay, Paul Zumbo, Nathan Brinkman, Charles S. Abrams, Stefano Rivella, Shilpa Hattangadi, Christopher E. Mason, Ronald Hoffman, Peng Ji, Antonia Follenzi, Yelena Z. Ginzburg
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Maria Feola et al., elucidate the compensatory role of pleckstrin-2 in ineffective erythropoiesis in β-thalassemic mice by reducing cofilin-mediated apoptosis and enhancing enucleation by activating RacGTPases. These findings could support future th
Externí odkaz:
https://doaj.org/article/e6bba204b45a41b58086958c1edd4975
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 4, Pp 531-542 (2020)
Abstract Attempts to expand ex vivo the numbers of human hematopoietic stem cells (HSCs) without compromising their marrow repopulating capacity and their ability to establish multilineage hematopoiesis has been the subject of intense investigation.
Externí odkaz:
https://doaj.org/article/6d6992c2a7b74404b3b2ef5cabb9be85
Autor:
Luena Papa, Mansour Djedaini, Tiphaine C. Martin, Mahtab Zangui, Kristin G. Beaumont, Robert Sebra, Ramon Parsons, Christoph Schaniel, Ronald Hoffman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Ex vivo expansion strategies of human hematopoietic stem cell (HSC) grafts with suboptimal stem cell dose have emerged as promising strategies for improving outcomes of HSC transplantation in patients with hematological malignancies. While exposure o
Externí odkaz:
https://doaj.org/article/81e1d7290d9e49df8cb28b6a6ed70a9b
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Quiescent and self-renewing hematopoietic stem cells (HSCs) rely on glycolysis rather than on mitochondrial oxidative phosphorylation (OxPHOS) for energy production. HSC reliance on glycolysis is considered an adaptation to the hypoxic environment of
Externí odkaz:
https://doaj.org/article/13cfc7f6ea724169856c6aebaec5b981
Autor:
Luena Papa, Tiphaine C. Martin, Mansour Djedaini, Mahtab Zangui, Umut Ozbek, Ramon Parsons, Ronald Hoffman, Christoph Schaniel
Publikováno v:
Experimental Hematology. 122:41-54
Autor:
Doris Germain, Samuel Waxman, Toshi Shioda, Julio Aguirre-Ghiso, Zhenyu Yue, Urvashi Bahadur, Luena Papa, Yuki Ishii
Purpose: Fulvestrant is known to promote the degradation of the estrogen receptor (ER) in the nucleus. However, fulvestrant also promotes the aggregation of the newly synthesized ER in the cytoplasm. Accumulation of protein aggregates leads to cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d1507793ebffe88080d2a6336fd32d
https://doi.org/10.1158/1078-0432.c.6519534
https://doi.org/10.1158/1078-0432.c.6519534
Autor:
Doris Germain, Samuel Waxman, Toshi Shioda, Julio Aguirre-Ghiso, Zhenyu Yue, Urvashi Bahadur, Luena Papa, Yuki Ishii
Supplementary Figure S1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f84fcb6ffe9a0e30922f9a41626eecf
https://doi.org/10.1158/1078-0432.22442901.v1
https://doi.org/10.1158/1078-0432.22442901.v1
Autor:
Ronald Hoffman, Manisha Kintali, Christoph Schaniel, Camelia Iancu-Rubin, Luena Papa, Mansour Djedaini, Marcia Meseck, Mahtab Zangui
Publikováno v:
Cytotherapy. 23:841-851
Background aims Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for a wide range of malignant and genetic disorders of the hematopoietic and immune systems. Umbilical cord blood (UCB) is a readily avai
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 4, Pp 531-542 (2020)
Stem Cells Translational Medicine
Stem Cells Translational Medicine
Attempts to expand ex vivo the numbers of human hematopoietic stem cells (HSCs) without compromising their marrow repopulating capacity and their ability to establish multilineage hematopoiesis has been the subject of intense investigation. Although
Autor:
Nathan Brinkman, Andrea Zamperone, Tenzin Choesang, Ronald Hoffman, Christopher E. Mason, Marc Ruiz Martinez, Carla Casu, Matthew MacKay, Mansour Djedaini, Jose Javier Bravo-Cordero, Dechen Lama, Luena Papa, Yelena Ginzburg, Paul Zumbo, Daniel Moskop, Peng Ji, Julie Di Martino, Stefano Rivella, Maria Feola, Shilpa M. Hattangadi, Huiyong Chen, Charles S. Abrams, Antonia Follenzi
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Erythropoiesis involves complex interrelated molecular signals influencing cell survival, differentiation, and enucleation. Diseases associated with ineffective erythropoiesis, such as β-thalassemias, exhibit erythroid expansion and defective enucle