Gugulipid causes hypercholesterolemia leading to endothelial dysfunction, increased atherosclerosis, and premature death by ischemic heart disease in male mice.

Autor: Andrea Leiva, Susana Contreras-Duarte, Ludwig Amigo, Esteban Sepúlveda, Mauricio Boric, Verónica Quiñones, Dolores Busso, Attilio Rigotti

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0184280 (2017)

For proper cholesterol metabolism, normal expression and function of scavenger receptor class B type I (SR-BI), a high-density lipoprotein (HDL) receptor, is required. Among the factors that regulate overall cholesterol homeostasis and HDL metabolism

Externí odkaz: https://doaj.org/article/02892ecd64c04ab79e54c19ce19431ad

Metabolic effects of cholecystectomy: gallbladder ablation increases basal metabolic rate through G-protein coupled bile acid receptor Gpbar1-dependent mechanisms in mice.

Autor: Víctor Cortés, Ludwig Amigo, Silvana Zanlungo, José Galgani, Fermín Robledo, Marco Arrese, Francisco Bozinovic, Flavio Nervi

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0118478 (2015)

Bile acids (BAs) regulate energy expenditure by activating G-protein Coupled Bile Acid Receptor Gpbar1/TGR5 by cAMP-dependent mechanisms. Cholecystectomy (XGB) increases BAs recirculation rates resulting in increased tissue exposure to BAs during the

Externí odkaz: https://doaj.org/article/7d912cd9b8e040ebb18d124dd0e894f1

Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice

Autor: Pablo Mardones, Verónica Quiñones, Ludwig Amigo, Mauricio Moreno, Juan Francisco Miquel, Margrit Schwarz, Helena E. Miettinen, Bernardo Trigatti, Monty Krieger, Sonya VanPatten, David E. Cohen, Attilio Rigotti

Publikováno v: Journal of Lipid Research, Vol 42, Iss 2, Pp 170-180 (2001)

The scavenger receptor class B type I (SR-BI), which is expressed in the liver and intestine, plays a critical role in cholesterol metabolism in rodents. While hepatic SR-BI expression controls high density lipoprotein (HDL) cholesterol metabolism, i

Externí odkaz: https://doaj.org/article/078cee3e07fd47129971ceb50db39312

HDL Receptor SR-B1 Deficiency Increased Inflammatory Dyslipidemia and Adipocyte Hypertrophy and Attenuated the Hepatic Steatosis in Murine Diet-Induced Obesity

Autor: Katherine Rivera, Daniel Cabrera, Verónica Quiñones, Marta Fernández-Galilea, Dolores Busso, Marcelo E. Andia, Ludwig Amigo, Marco Arrese, Gonzalo Carrasco, Aline Xavier, Attilio Rigotti

Publikováno v: Curr Dev Nutr

OBJECTIVES: We tested whether the scavenger receptor, class B type 1 (SR-B1), a physiologically relevant HDL receptor, modulates the metabolic and inflammatory phenotype of obese mice, accompanied by changes in adipocyte and hepatocyte lipid deposits

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03701c316e03ad868de965df8593346c
https://europepmc.org/articles/PMC7259110/

Transgenic overexpression of Niemann-Pick C2 protein promotes cholesterol gallstone formation in mice

Autor: Juan Castro, Mariana Acuña, Gonzalo I. Cancino, Silvana Zanlungo, Ludwig Amigo, Albert K. Groen, Juan Francisco Miquel, Juan Young, M. Gabriela Morales, Lila González-Hódar

Publikováno v: Journal of Hepatology, 64(2), 361-369. ELSEVIER SCIENCE BV
Journal of hepatology, 64(2), 361-369. Elsevier
Journal of Hepatology
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Background & Aims: Niemann-Pick C2 (NPC2) is a lysosomal protein involved in the egress of low-density lipoprotein-derived cholesterol from lysosomes to other intracellular compartments. NPC2 has been detected in several tissues and is also secreted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed964f7d55e636e03cf034e7d094a1e7
https://doi.org/10.1016/j.jhep.2015.10.002