Výsledky vyhledávání - "Ludwig, Franziska"

The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation

Autor: Zhang, Peipei, Schlecht, Anja, Wolf, Julian, Boneva, Stefaniya, Laich, Yannik, Koch, Jana, Ludwig, Franziska, Boeck, Myriam, Thien, Adrian, Härdtner, Carmen, Kierdorf, Katrin, Agostini, Hansjürgen, Schlunck, Günther, Prinz, Marco, Hilgendorf, Ingo, Wieghofer, Peter, Lange, Clemens

Publikováno v: Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Journal of Neuroinflammation

Background Microglia cells represent the resident innate immune cells of the retina and are important for retinal development and tissue homeostasis. However, dysfunctional microglia can have a negative impact on the structural and functional integri

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https://doaj.org/article/f0b2242fbf2d4c6787d1cd668f61b8e7

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Additional file 1 of The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation

Additional file 1. Supplemental figure 1 Irf8 is expressed predominantly in retinal MG and in some bipolar or Müller cells. No Irf8-VENUS expression could be detected co-localised with GFAP (A), βIII-Tubulin (B) and Collagen IV (E), indicating that

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Additional file 3 of The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation

Additional file 3. Supplemental figure 3 Irf8 deficiency does not affect the retinal structure, function and vasculature. A-C Representative color fundus images (A), fluorescein angiography (B) and optical coherence tomography (OCT) images of Irf8 WT

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Additional file 4 of The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation

Additional file 4. Supplemental figure 4 Spatial distribution of retinal microglia in CNV lesions. A Spatial distribution of microglia in the inner plexiform layer (IPL) in lasered and unlasered Irf8 WT and Irf8 KO mice. B Quantification of the numbe

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Additional file 5 of The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation

Additional file 5. Supplemental figure 5: Polarisation markers expressed by CNV-associated microglia. The M1 and M2 polarisation markers Cd86, H2-Ab1, Tlr2, Cd163 and Mrc1 (CD206) are shown as transcripts per million in comparison between Irf8 WT and

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Additional file 7 of The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation

Additional file 7. Supplemental table 2: List of antibodies used for immunohistochemistry and flow cytometry.

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Additional file 2 of The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation

Additional file 2. Supplemental figure 2 Temporal and spatial distribution of retinal microglia during development. A Representative pictures showing the numbers of microglia per field of view in Irf8 WT and Irf8 KO mice in comparison between the gan

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