Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Ludwicka-Bradley A"'
Publikováno v:
Journal of Aging Research, Vol 2013 (2013)
Endothelial microparticles (EMPs) are complex vesicular structures that originate from plasma membranes of activated or apoptotic endothelial cells. EMPs play a significant role in vascular function by altering the processes of inflammation, coagulat
Externí odkaz:
https://doaj.org/article/d12ff4ad01854bf0af204a9eeb6f891d
Publikováno v:
Journal of Aging Research, Vol 2013 (2013)
Journal of Aging Research
Journal of Aging Research
Endothelial microparticles (EMPs) are complex vesicular structures that originate from plasma membranes of activated or apoptotic endothelial cells. EMPs play a significant role in vascular function by altering the processes of inflammation, coagulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f75b6480d55433b869fd3e6a30c5b56
https://doi.org/10.1155/2013/734509
https://doi.org/10.1155/2013/734509
Publikováno v:
Seminars in Arthritis and Rheumatism. 41:212-222
Objectives Interstitial lung disease in systemic sclerosis (SSc-ILD) is often an irreversible and progressive fibrosing process that now is the leading cause of scleroderma-related deaths. In this review we present our current understanding of the ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d89aaf67cdea992e0298ca546da0919
https://doi.org/10.1016/j.semarthrit.2010.10.002
https://doi.org/10.1016/j.semarthrit.2010.10.002
Publikováno v:
Arthritis & Rheumatism. 60:3455-3464
Objective Myofibroblasts are the principal mesenchymal cells responsible for tissue remodeling, collagen deposition, and the restrictive nature of lung parenchyma associated with pulmonary fibrosis. We previously reported that thrombin activates prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5e52fd482361eb03c3fc7c689bae1bc
https://doi.org/10.1002/art.24935
https://doi.org/10.1002/art.24935
Autor:
Anna Ludwicka-Bradley, Richard M. Silver, Jennifer R. Bethard, C. Beth Singleton, Galina S. Bogatkevich
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 295:L603-L611
Connective tissue growth factor (CTGF, CCN2) is overexpressed in lung fibroblasts isolated from patients with interstitial lung disease (ILD) and systemic sclerosis (SSc, scleroderma) and is considered to be a molecular marker of fibrosis. To underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb0bd46e236540b8396167ace72d59f
https://doi.org/10.1152/ajplung.00530.2007
https://doi.org/10.1152/ajplung.00530.2007
Autor:
Paul J. Nietert, Anna Ludwicka-Bradley, Faye N. Hant, Richard M. Silver, Kristin B. Highland, Galina S. Bogatkevich, C. Beth Singleton, Carol Feghali-Bostwick
Publikováno v:
Arthritis & Rheumatism. 56:2432-2442
Objective To compare the composition of cytokines in African American and Caucasian patients with systemic sclerosis (SSc; scleroderma) and in healthy individuals, particularly the expression and function of hepatocyte growth factor (HGF). Methods Br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0382d5cc03e042edbce1e1ab271a3a8f
https://doi.org/10.1002/art.22713
https://doi.org/10.1002/art.22713
Autor:
Elena Tourkina, Jim C. Oates, Stanley Hoffman, Anna Ludwicka-Bradley, Richard M. Silver, Pal Gooz
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 31:28-35
Scleroderma, a disease involving excessive collagen deposition, can be studied using fibroblasts cultured from affected tissues. We find that curcumin, the active component of the spice turmeric, causes apoptosis in scleroderma lung fibroblasts (SLF)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465eb13fb9acd110b9807ff1e79a70c0
https://doi.org/10.1165/rcmb.2003-0354oc
https://doi.org/10.1165/rcmb.2003-0354oc
Autor:
Russell A. Harley, Anna Ludwicka-Bradley, Richard M. Silver, Galina S. Bogatkevich, Elena Tourkina, Charles S. Abrams
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 285:L334-L343
Activated fibroblasts, or myofibroblasts, are crucial players in tissue remodeling, wound healing, and various fibrotic disorders, including interstitial lung fibrosis associated with scleroderma. Here we characterize the signaling pathways in normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38d0173fcc4134606f440f2c6b9ee08
https://doi.org/10.1152/ajplung.00417.2002
https://doi.org/10.1152/ajplung.00417.2002
Publikováno v:
Journal of Biological Chemistry. 276:45184-45192
Myofibroblasts are ultrastructurally and metabolically distinctive fibroblasts that express smooth muscle (SM)-alpha actin and are associated with various fibrotic lesions. The present study was undertaken to investigate the myofibroblast phenotype t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67ca7210492638ae29210983a6afd21
https://doi.org/10.1074/jbc.m106441200
https://doi.org/10.1074/jbc.m106441200
Autor:
Richard M. Silver, John W. Fenton, Elena Tourkina, Stanley Hoffman, Anna Ludwicka-Bradley, Stuart R. Lipsitz
Publikováno v:
Arthritis & Rheumatism. 44:1370-1381
Objective To determine whether the extracellular matrix protein tenascin-C (TN-C) is overexpressed in lung fibroblasts from systemic sclerosis (SSc) patients, the molecular mechanisms regulating TN-C secretion in SSc and normal lung fibroblasts, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c2a26a39d10c452cb06f8836702a2a6
https://doi.org/10.1002/1529-0131(200106)44:6<1370::aid-art230>3.0.co
https://doi.org/10.1002/1529-0131(200106)44:6<1370::aid-art230>3.0.co