Initiation of lumen formation from junctions via differential actomyosin contractility regulated by dynamic recruitment of Rasip1

Autor: Jianmin Yin, Niels Schellinx, Ludovico Maggi, Kathrin Gundel, Cora Wiesner, Maria Paraskevi Kotini, Minkyoung Lee, Li-Kun Phng, Heinz-Georg Belting, Markus Affolter

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract De novo lumen formation necessitates the precise segregation of junctional proteins from apical surfaces, yet the underlying mechanisms remain unclear. Using a zebrafish model, we develop a series of molecular reporters, photo-convertible an

Externí odkaz: https://doaj.org/article/cac7d75bd81e4deaae5f1a4918d65a3d

Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes

Autor: Katherine Roberts-Thomson, Ludovico Maggi, Susanne Hille, Annika Zota, Yuqin Wu, Kathrin V. Schmidt, Michelle A. Keske, Yann W. Yap, Young H Lee, Thomas Sharkie, Andrea Y. Chan, Mathias Heikenwalder, Jürgen G. Okun, Andreas Jungmann, Ryan D. Russell, Stephan Herzig, Patricia M. Rusu, Oliver J. Müller, Matthias Blüher, Adam J. Rose, Jonas Schumacher

Publikováno v: Nature metabolism. 3(3)

Both obesity and sarcopenia are frequently associated in ageing, and together may promote the progression of related conditions such as diabetes and frailty. However, little is known about the pathophysiological mechanisms underpinning this associati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8118b443e91758d3dae8feac62e56d33
https://pubmed.ncbi.nlm.nih.gov/33795840

A Model of Superinfection of Virus-Infected Zebrafish Larvae: Increased Susceptibility to Bacteria Associated With Neutrophil Death

Autor: Valéry Thiry, Ludovico Maggi, Laurent Boucontet, Jean-Pierre Levraud, Gabriella Passoni, Emma Colucci-Guyon, Philippe Herbomel

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 2018, 9, pp.1084. ⟨10.3389/fimmu.2018.01084⟩
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, Frontiers, 2018, 9, pp.1084. ⟨10.3389/fimmu.2018.01084⟩

International audience; Enhanced susceptibility to bacterial infection in the days following an acute virus infection such as flu is a major clinical problem. Mouse models have provided major advances in understanding viral-bacterial superinfections,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1e0bb8db2330e7c7eb93192d7664ad