Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ludovica Zaccagnini"'
Autor:
Kambiz Hassanzadeh, Castrese Morrone, Keivan Akhtari, Ellen Gerhardt, Ludovica Zaccagnini, Tiago Fleming Outeiro, Marco Feligioni
Publikováno v:
Mechanisms of ageing and development 209, 111759 (2023). doi:10.1016/j.mad.2022.111759
The exon skipping of α-Synuclein (α-Syn), the main constituent of the abnormal protein aggregation in Lewy bodies of Parkinson's disease (PD), forms four isoforms. In contrast to the full length α-Syn (α-Syn 140), little is known about the splice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ca16c86426562edccb2cadf5a7c7f2
https://pub.dzne.de/record/169127
https://pub.dzne.de/record/169127
Autor:
Isabel Lam, Alain Ndayisaba, Amanda J. Lewis, YuHong Fu, Giselle T. Sagredo, Ludovica Zaccagnini, Jackson Sandoe, Ricardo L. Sanz, Aazam Vahdatshoar, Timothy D. Martin, Nader Morshed, Toru Ichihashi, Arati Tripathi, Nagendran Ramalingam, Charlotte Oettgen-Suazo, Theresa Bartels, Max Schäbinger, Erinc Hallacli, Xin Jiang, Amrita Verma, Challana Tea, Zichen Wang, Hiroyuki Hakozaki, Xiao Yu, Kelly Hyles, Chansaem Park, Thorold W. Theunissen, Haoyi Wang, Rudolf Jaenisch, Susan Lindquist, Beth Stevens, Nadia Stefanova, Gregor Wenning, Kelvin C. Luk, Rosario Sanchez Pernaute, Juan Carlos Gómez-Esteban, Daniel Felsky, Yasujiro Kiyota, Nidhi Sahni, S. Stephen Yi, Chee-Yeun Chung, Henning Stahlberg, Isidro Ferrer, Johannes Schöneberg, Stephen J. Elledge, Ulf Dettmer, Glenda M. Halliday, Tim Bartels, Vikram Khurana
Intracellular inclusions accompanying neurodegeneration are histopathologically and ultrastructurally heterogeneous but the significance of this heterogeneity is unclear. iPSC models, while promising for disease modeling, do not form inclusions in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c012494b212921233507969b33cb45f
https://doi.org/10.1101/2022.11.08.515615
https://doi.org/10.1101/2022.11.08.515615
Autor:
Laura de Boni, Aurelia Hays Watson, Ludovica Zaccagnini, Amber Wallis, Kristina Zhelcheska, Nora Kim, John Sanderson, Haiyang Jiang, Elodie Martin, Adam Cantlon, Matteo Rovere, Lei Liu, Marc Sylvester, Tammaryn Lashley, Ulf Dettmer, Zane Jaunmuktane, Tim Bartels
Publikováno v:
Acta neuropathologica. 143(4)
The protein α-synuclein, a key player in Parkinson’s disease (PD) and other synucleinopathies, exists in different physiological conformations: cytosolic unfolded aggregation-prone monomers and helical aggregation-resistant multimers. It has been
Autor:
Lei Liu, Ulf Dettmer, Aurelia Hays Watson, Ludovica Zaccagnini, Zane Jaunmuktane, Nora C. Kim, Marc Sylvester, Adam Cantlon, Elodie Martin, Matteo Rovere, Haiyang Jiang, John B. Sanderson, Tim Bartels, Tammaryn Lashley, Laura de Boni
The α-synuclein protein (αS) is the major constituent of pathological neuronal inclusions both in Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB) with differential brain region-specific pathology patterns and clinical presentations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b087e04b4e0d12bca83b7ae2209e395a
https://doi.org/10.21203/rs.3.rs-294515/v1
https://doi.org/10.21203/rs.3.rs-294515/v1
Autor:
Thomas C. Pochapsky, Tracy L. Young-Pearse, Bradley T. Hyman, John B. Sanderson, Laura de Boni, Dennis J. Selkoe, Xinyue Liu, Suman De, Valentina N. Lagomarsino, Haiyang Jiang, Ming Jin, Aurelia Hays Watson, Dennis W. Dickson, David Klenerman, Tim Bartels, Ludovica Zaccagnini, Matteo Rovere
Publikováno v:
Brain Communications
Since researchers identified α-synuclein as the principal component of Lewy bodies and Lewy neurites, studies have suggested that it plays a causative role in the pathogenesis of dementia with Lewy bodies and other ‘synucleinopathies’. While α-
Autor:
Stefania Butini, Giuseppe Campiani, Giulia Chemi, Ludovica Zaccagnini, Sandra Gemma, Giuseppe Legname, Simone Brogi, Margherita Brindisi
Publikováno v:
European Journal of Medicinal Chemistry. 127:859-873
Prion diseases are serious, not curable neurodegenerative disorders caused by the accumulation of the misfolded protein PrP(Sc) that represents the pathological variant of the normally folded cellular protein PrP(C). Molecules that bind the cellular
Autor:
Annachiara Gandini, Maria Laura Bolognesi, Giulia Rossetti, Arianna Colini Baldeschi, Paolo Carloni, Ludovica Zaccagnini, Thanh Hoa Tran, Giuseppe Legname, Giulia Salzano
Publikováno v:
European journal of medicinal chemistry 196, 112295 (2020). doi:10.1016/j.ejmech.2020.112295
Prion diseases or transmissible spongiform encephalopathies (TSEs) are a group of rare neurodegenerative disorders. TSEs are characterized by the accumulation of prions (PrPSc) that represent pathological isoforms of the physiological cellular prion
Autor:
Ludovica, Zaccagnini, Simone, Brogi, Margherita, Brindisi, Sandra, Gemma, Giulia, Chemi, Giuseppe, Legname, Giuseppe, Campiani, Stefania, Butini
Publikováno v:
European journal of medicinal chemistry. 127
Prion diseases are serious, not curable neurodegenerative disorders caused by the accumulation of the misfolded protein PrP