Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Ludovic Zimmerlin"'
Autor:
Justin Thomas, Ludovic Zimmerlin, Jeffrey S. Huo, Michael Considine, Leslie Cope, Elias T. Zambidis
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-13 (2021)
Abstract Human pluripotent stem cells (hPSCs) can generate specialized cell lineages that have great potential for regenerative therapies and disease modeling. However, the developmental stage of the lineages generated from conventional hPSC cultures
Externí odkaz:
https://doaj.org/article/2d63db817ceb45c390898d2afa8999ce
Autor:
Tea Soon Park, Ludovic Zimmerlin, Rebecca Evans-Moses, Justin Thomas, Jeffrey S. Huo, Riya Kanherkar, Alice He, Nensi Ruzgar, Rhonda Grebe, Imran Bhutto, Michael Barbato, Michael A. Koldobskiy, Gerard Lutty, Elias T. Zambidis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
hPSCs in culture acquire a more naïve pluripotent state upon tankyrase inhibition. Here, the authors show that tankyrase inhibitor-regulated naïve hiPSCs from diabetic donors generate more vascular progenitors and more efficient engraftment into mo
Externí odkaz:
https://doaj.org/article/4cd3936d370a4ba1b02244ee053db93b
Autor:
William C. W. Chen, Tea Soon Park, Iain R. Murray, Ludovic Zimmerlin, Lorenza Lazzari, Johnny Huard, Bruno Péault
Publikováno v:
Stem Cells International, Vol 2013 (2013)
Mesenchymal stem/stromal cells (MSCs) and MSC-like multipotent stem/progenitor cells have been widely investigated for regenerative medicine and deemed promising in clinical applications. In order to further improve MSC-based stem cell therapeutics,
Externí odkaz:
https://doaj.org/article/0212b49fa03f4a05a52a8dabd0281538
Autor:
Albert D Donnenberg, Ludovic Zimmerlin, Rodney J Landreneau, James D Luketich, Vera S Donnenberg
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52885 (2012)
We have previously described the expression of CD44, CD90, CD117 and CD133 in NSCLC tumors, adjacent normal lung, and malignant pleural effusions (MPE). Here we describe the unique subset of tumors expressing CD117 (KIT), a potential therapeutic targ
Externí odkaz:
https://doaj.org/article/5ac7290c773c4400976be024e8b742ca
Autor:
Tea Soon Park, Jeffrey S Huo, Ann Peters, C Conover Talbot, Karan Verma, Ludovic Zimmerlin, Ian M Kaplan, Elias T Zambidis
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42838 (2012)
Nonviral conversion of skin or blood cells into clinically useful human induced pluripotent stem cells (hiPSC) occurs in only rare fractions (~0.001%-0.5%) of donor cells transfected with non-integrating reprogramming factors. Pluripotency induction
Externí odkaz:
https://doaj.org/article/bb295cefd4024c0da87cf3df9bb3a84c
Autor:
Michael I. Barbato, Imran Ahmed Bhutto, Riya Kanherkar, Ludovic Zimmerlin, Justin Thomas, Jeffrey S. Huo, Elias T. Zambidis, Nensi Ruzgar, Tea Soon Park, G. A. Lutty, Rhonda Grebe, Michael A. Koldobskiy, Rebecca Evans-Moses, Alice He
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Nature Communications
Here, we report that the functionality of vascular progenitors (VP) generated from normal and disease-primed conventional human induced pluripotent stem cells (hiPSC) can be significantly improved by reversion to a tankyrase inhibitor-regulated human
Publikováno v:
Methods Mol Biol
Methods in Molecular Biology ISBN: 9781071619070
Methods in Molecular Biology ISBN: 9781071619070
Tankyrase/PARP inhibitor-regulated naïve human pluripotent stem cells (TIRN-hPSC) represent a new class of human stem cells for regenerative medicine that can differentiate into multi-lineage progenitors with improved in vivo functionality. Chemical
Autor:
Elias T. Zambidis, Leslie Cope, Ludovic Zimmerlin, Jeffrey S. Huo, Justin Thomas, Michael Considine
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-13 (2021)
NPJ Regenerative Medicine
NPJ Regenerative Medicine
Human pluripotent stem cells (hPSCs) can generate specialized cell lineages that have great potential for regenerative therapies and disease modeling. However, the developmental stage of the lineages generated from conventional hPSC cultures in vitro
Autor:
Cheng Cui, Rahul Suresh, Elias T. Zambidis, Theresa Barberi, Alan D. Friedman, Ludovic Zimmerlin
Publikováno v:
Regular and young investigator award abstracts.
Background High-risk neuroblastomas, including those with MYCN gene amplification, harbor abundant myeloid cells that suppress anti-tumor immunity and favor tumor growth. Macrophages lacking the inhibitory NF-κB p50 subunit adopt an M1-polarized, T-
Autor:
Ludovic Zimmerlin, Elias T. Zambidis
Publikováno v:
Exp Cell Res
Tankyrase 1 (TNKS1; PARP-5a) and Tankyrase 2 (TNKS2; PARP-5b) are poly-ADP-ribosyl-polymerase (PARP)-domain-containing proteins that regulate the activities of a wide repertoire of target proteins via post-translational addition of poly-ADP-ribose po