Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ludovic Otterbein"'
Autor:
Haris Jahic, Kerry E. Murphy-Benenato, P. Ann Boriack-Sjodin, Dan Carcanague, Jenna Harang, Tina Howard, Claire Brassington, Madhusudhan Reddy Gowravaram, Charles J. Eyermann, Lakshmaiah Gingipalli, Herbert Oguto, Sahil Patel, Robert A. Giacobbe, Ludovic Otterbein, Amy Kutschke, James T. Loch, Georgine Ioannidis, Valerie A. Laganas, Michael R. Hale, Adam B. Shapiro, Kevin J. Embrey, Matthew D. Miller
Publikováno v:
Tetrahedron Letters. 56:3108-3112
Bacterial NAD+-dependent DNA ligase (LigA) is an essential enzyme involved in the repair, replication, and recombination of DNA in all bacteria, making it an attractive target in antibacterial drug discovery. A novel series of LigA inhibitors was dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fe2683d6839ef615d9bfebf560d10c8
https://doi.org/10.1016/j.tetlet.2014.12.067
https://doi.org/10.1016/j.tetlet.2014.12.067
Autor:
Suzanne Stokes, Robert Albert, Andrew R. McKenzie, Beth Andrews, Ed T. Buurman, Oluyinka Green, Adam B. Shapiro, Ludovic Otterbein
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7019-7023
A previously described aryl sulfonamide series, originally found through HTS, targets GlmU, a bifunctional essential enzyme involved in bacterial cell wall synthesis. Using structure-guided design, the potency of enzyme inhibition was increased in mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd8591754e98fff3c3f3047314914a1
https://doi.org/10.1016/j.bmcl.2012.10.003
https://doi.org/10.1016/j.bmcl.2012.10.003
Autor:
Catherine Madzak, Marcel Asther, Serge Moukha, Ludovic Otterbein, Jean-Marie Beckerich, Claude Gaillardin, Mohamed Chamkha
Publikováno v:
FEMS Yeast Research. 5:635-646
Pycnoporus cinnabarinus lac1 gene was expressed in Yarrowia lipolytica. Different secretion signals and culture media were tested. Production was correlated to both culture growth rate and cell morphology (highest at low growth rate, without mycelium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecfee753e73266a1a364dbba82dfe662
https://doi.org/10.1016/j.femsyr.2004.10.009
https://doi.org/10.1016/j.femsyr.2004.10.009
Publikováno v:
European Journal of Biochemistry. 267:1619-1625
Laccases are multicopper-containing enzymes which catalyse the oxidation of phenolic and nonphenolic compounds with the concomitant reduction of molecular oxygen. In this study, a full-length cDNA coding for laccase (lac1) from Pycnoporus cinnabarinu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::438d88b1873090bc23c8b7cbaf89b105
https://doi.org/10.1046/j.1432-1327.2000.01166.x
https://doi.org/10.1046/j.1432-1327.2000.01166.x
Autor:
Ludovic Otterbein, Eric Record, David Chereau, Isabelle Herpoël, Marcel Asther, Serge M. Moukha
Publikováno v:
Canadian Journal of Microbiology. 46:759-763
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c19dd6d0081717f9292a82a5d2f0ee1
https://doi.org/10.1139/cjm-46-8-759
https://doi.org/10.1139/cjm-46-8-759
Autor:
Oluyinka Green, Haihong Ni, Arthur D. Patten, Sameer Kawatkar, Robert Albert, Jason Breed, Suzanne Stokes, Ludovic Otterbein, Andrew R. McKenzie, Adam B. Shapiro
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(4)
A novel arylsulfonamide-containing series of compounds represented by 1, discovered by highthroughput screening, inhibit the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c719b54c25811e97fb3d60a72fe33bd
https://pubmed.ncbi.nlm.nih.gov/22297115
https://pubmed.ncbi.nlm.nih.gov/22297115
Autor:
Allen Jack Mcqueen, Jason Breed, Tim P. Green, Patrick Ple, Nicolas Warin, Rémy Morgentin, Richard A. Norman, Michael Fennell, Gerard Costello, Christine Lambert-van der Brempt, Annie Olivier, Ludovic Otterbein, Jon Curwen, Laurent Francois Andre Hennequin
Publikováno v:
Journal of medicinal chemistry. 49(22)
Src family kinases (SFKs) are nonreceptor tyrosine kinases that are reported to be critical for cancer progression. We report here a novel subseries of C-5-substituted anilinoquinazolines that display high affinity and specificity for the tyrosine ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4452f4ef554b2005ee24f769fb1a99
https://pubmed.ncbi.nlm.nih.gov/17064066
https://pubmed.ncbi.nlm.nih.gov/17064066
Autor:
Paul Robert Owen Whittamore, Nikos G. Oikonomakos, Peter W. Kenny, Dave P. Whalley, Ludovic Otterbein, Paul Schofield, Alan Martin Birch
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(2)
A series of substituted 3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors, which have potential as antidiabetic agents, is described. Initial members of the series showed good enzyme inhibitory potency but poor physical properties. Optimisati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97aa4d7ed4d7ff8e566967eeab6151cf
https://pubmed.ncbi.nlm.nih.gov/17095214
https://pubmed.ncbi.nlm.nih.gov/17095214
Autor:
Michael Butters, Alan Martin Birch, Peter W. Kenny, Pawel Siedlecki, Paul Robert Owen Whittamore, Jennifer Whitehouse, Ludovic Otterbein, Matthew S. Addie, Andrew Pannifer, Melvyn J. Taylor, Paul M. Murray, Linda Godfrey, David Whalley, Andy Stocker, Jeremy S. Parker, Andrew David Morley, Nikos G. Oikonomakos, Kristy Readman, Linda A. Townsend, Stuart Norman Lile Bennett, Paul Schofield
Publikováno v:
Bioorganic & Medicinal Chemistry Letters 16:21(Nov2006):5567-5571
Two series of novel thienopyrrole inhibitors of recombinant human liver glycogen phosphorylase a (GPa) which are effective in reducing glucose output from rat hepatocytes are described. Representative compounds have been shown to bind at the dimer in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a027fdd96a6fc9f365265c8ad7e44fb1
https://pubmed.ncbi.nlm.nih.gov/16945526
https://pubmed.ncbi.nlm.nih.gov/16945526
Autor:
Catherine, Madzak, Ludovic, Otterbein, Mohamed, Chamkha, Serge, Moukha, Marcel, Asther, Claude, Gaillardin, Jean-Marie, Beckerich
Publikováno v:
FEMS yeast research. 5(6-7)
Pycnoporus cinnabarinus lac1 gene was expressed in Yarrowia lipolytica. Different secretion signals and culture media were tested. Production was correlated to both culture growth rate and cell morphology (highest at low growth rate, without mycelium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e3a313ab261d29daf828c1fcae497bd
https://pubmed.ncbi.nlm.nih.gov/15780663
https://pubmed.ncbi.nlm.nih.gov/15780663