Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Ludovic Le Hegarat"'
1
Akademický článek
Genotoxicity of Aluminum and Aluminum Oxide Nanomaterials in Rats Following Oral Exposure
Autor: Pégah Jalili, Sylvie Huet, Rachelle Lanceleur, Gérard Jarry, Ludovic Le Hegarat, Fabrice Nesslany, Kevin Hogeveen, Valérie Fessard
Publikováno v: Nanomaterials, Vol 10, Iss 2, p 305 (2020)
Due to several gaps remaining in the toxicological evaluation of nanomaterials (NMs), consumers and public health agencies have shown increasing concern for human health protection. In addition to aluminum (Al) microparticles, Al-containing nanomater
Externí odkaz: https://doaj.org/article/d7766fa1f7454035a2d8514459513059
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2
Akademický článek
Metabolism of the Marine Phycotoxin PTX-2 and Its Effects on Hepatic Xenobiotic Metabolism: Activation of Nuclear Receptors and Modulation of the Phase I Cytochrome P450
Autor: Jimmy Alarcan, Estelle Dubreil, Antoine Huguet, Dominique Hurtaud-Pessel, Stefanie Hessel-Pras, Alfonso Lampen, Valérie Fessard, Ludovic Le Hegarat
Publikováno v: Toxins, Vol 9, Iss 7, p 212 (2017)
PTX-2 is a marine biotoxin frequently found in shellfish that can lead to food intoxication in humans. Information regarding PTX-2 metabolism is scarce, and little is known of its effect on xenobiotic-metabolizing enzymes (XME) or its molecular pathw
Externí odkaz: https://doaj.org/article/f5c45aea20934c789590e5ab35a15b09
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5
An Evaluation of the Cytotoxic and Genotoxic Effects of the Marine Toxin C17-SAMT in Human TK6 and HepaRG Cell Lines
Autor: Zeineb Marzougui, Ludovic Le Hegarat, Kevin Hogeveen, Sylvie Huet, Riadh Kharrat, Riadh Marrouchi, Valérie Fessard
Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 7805
This study investigates the genotoxicity and cytotoxicity of C17-sphinganine analog mycotoxin (C17-SAMT) using in vitro assays. C17-SAMT was previously identified as the cause of unusual toxicity in cultured mussels from the Bizerte Lagoon in norther
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb9ebcf2767afb890cab8e48ef35c2a
https://doi.org/10.3390/ijms24097805
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6
Akademický článek
Genotoxicity of beauvericin
Autor: EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Guido Rychen, Salomon Sand, Tanja Schwerdtle, Katharina Vejdovszky, Barbara Viviani, Emanuela Corsini, Ludovic Le Hégarat, Hans Steinkellner, Margherita Bignami
Publikováno v: EFSA Journal, Vol 22, Iss 10, Pp n/a-n/a (2024)
Abstract The European Commission (EC) asked EFSA to assess the genotoxicity of beauvericin (BEA). Relevant information, including that which has become available since the 2014 Scientific Opinion on the risks to human and animal health related to the
Externí odkaz: https://doaj.org/article/9c94284c74794fd392adad62be675b2e
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8
Human T lymphocytes bioactivate heterocyclic aromatic amines by forming DNA adducts
Autor: Medjda, Bellamri, Ludovic, Le Hegarat, Laurent, Vernhet, Georges, Baffet, Robert J, Turesky, Sophie, Langouët
Publikováno v: Environmental and Molecular Mutagenesis
Environmental and Molecular Mutagenesis, Wiley-Blackwell, 2016, 57 (9), pp.656-667. ⟨10.1002/em.22059⟩
Environmental and Molecular Mutagenesis, 2016, 57 (9), pp.656-667. ⟨10.1002/em.22059⟩
International audience; Heterocyclic aromatic amines (HAA) are formed in cooked meat, poultry and fish but also arise in tobacco smoke and exhaust gases. HAA are potential human carcinogens, which require metabolic activation to exert their genotoxic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7f95a0adac71e86a9621ff540345fa3d
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01400486
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9
Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells
Autor: Carine Lambert, Marie-Anne Robin, André Guillouzo, Ludovic Le Hegarat, Rozenn Jossé, Julie Dumont, Sébastien Anthérieu, Caroline Aninat, Christiane Guguen-Guillouzo
Publikováno v: Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2010, 245 (2), pp.256-63. ⟨10.1016/j.taap.2010.03.008⟩
Toxicology and Applied Pharmacology, 2010, 245 (2), pp.256-63. ⟨10.1016/j.taap.2010.03.008⟩
Human exposure to heterocyclic aromatic amines (HAA) usually occurs through mixtures rather than individual compounds. However, the toxic effects and related mechanisms of co-exposure to HAA in humans remain unknown. We compared the effects of two of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1e2f97ecee624c7ce870b4d5e18047
https://hal-anses.archives-ouvertes.fr/hal-00533754
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10
Akademický článek
Investigation of the Genotoxic Potential of the Marine Toxin C17-SAMT Using the In Vivo Comet and Micronucleus Assays
Autor: Zeineb Marzougui, Sylvie Huet, Anne-Louise Blier, Ludovic Le Hégarat, Haïfa Tounsi-Kettiti, Riadh Kharrat, Riadh Marrouchi, Valérie Fessard
Publikováno v: Marine Drugs, Vol 20, Iss 10, p 619 (2022)
The contaminant responsible for the atypical toxicity reported in mussels from Bizerte Lagoon (Northern Tunisia) during the last decade has been characterized as C17-sphinganine analog mycotoxin (C17-SAMT). This neurotoxin showed common mouse toxic s
Externí odkaz: https://doaj.org/article/a3ee6c29331440c38f067f5da1feade7
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