In vitro genotoxicity potential investigation of 7 oxy‐PAHs

Autor: Adeline Clergé, Jérémie Le Goff, Emilie Brotin, Edwige Abeillard, Isabelle Vaudorne, Christophe Denoyelle, Ludovic Le Hegarat, Raphaël Delépée

Publikováno v: Environmental and Molecular Mutagenesis. 64:176-186

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e03273c260b250c0d2888edd81479b43
https://doi.org/10.1002/em.22531

Genotoxicity of Aluminum and Aluminum Oxide Nanomaterials in Rats Following Oral Exposure

Autor: Pégah Jalili, Sylvie Huet, Rachelle Lanceleur, Gérard Jarry, Ludovic Le Hegarat, Fabrice Nesslany, Kevin Hogeveen, Valérie Fessard

Publikováno v: Nanomaterials, Vol 10, Iss 2, p 305 (2020)

Due to several gaps remaining in the toxicological evaluation of nanomaterials (NMs), consumers and public health agencies have shown increasing concern for human health protection. In addition to aluminum (Al) microparticles, Al-containing nanomater

Externí odkaz: https://doaj.org/article/d7766fa1f7454035a2d8514459513059

Metabolism of the Marine Phycotoxin PTX-2 and Its Effects on Hepatic Xenobiotic Metabolism: Activation of Nuclear Receptors and Modulation of the Phase I Cytochrome P450

Autor: Jimmy Alarcan, Estelle Dubreil, Antoine Huguet, Dominique Hurtaud-Pessel, Stefanie Hessel-Pras, Alfonso Lampen, Valérie Fessard, Ludovic Le Hegarat

Publikováno v: Toxins, Vol 9, Iss 7, p 212 (2017)

PTX-2 is a marine biotoxin frequently found in shellfish that can lead to food intoxication in humans. Information regarding PTX-2 metabolism is scarce, and little is known of its effect on xenobiotic-metabolizing enzymes (XME) or its molecular pathw

Externí odkaz: https://doaj.org/article/f5c45aea20934c789590e5ab35a15b09

Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells

Autor: Carine Lambert, Marie-Anne Robin, André Guillouzo, Ludovic Le Hegarat, Rozenn Jossé, Julie Dumont, Sébastien Anthérieu, Caroline Aninat, Christiane Guguen-Guillouzo

Publikováno v: Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2010, 245 (2), pp.256-63. ⟨10.1016/j.taap.2010.03.008⟩
Toxicology and Applied Pharmacology, 2010, 245 (2), pp.256-63. ⟨10.1016/j.taap.2010.03.008⟩

Human exposure to heterocyclic aromatic amines (HAA) usually occurs through mixtures rather than individual compounds. However, the toxic effects and related mechanisms of co-exposure to HAA in humans remain unknown. We compared the effects of two of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1e2f97ecee624c7ce870b4d5e18047
https://hal-anses.archives-ouvertes.fr/hal-00533754

Avis de l'Anses relatif à l’évaluation des substances inscrites au programme de travail 2018-2019 de l’Agence dans le cadre de l’évaluation des substances sous REACH : le n-butyl trichloride (n°CAS 1118-46-3) et le dioxyde de titane (n°CAS 13463-67-7)

Autor: Jean Ulrich Mullot, Christophe Minier, Paule Vasseur, Fabrizio Pariselli, Isabelle Billault, Christophe Calvayrac, Marie-Laure Cointot, Richard Daniellou, Rene Habert, Guillermina Hernandez-Raquet, Ludovic Le Hegarat, Olwenn Martin, Laura Maxim, Laurence Musset, Cecile Quantin, Bernard Salles, Valerie Seror, Alain Simonnard, Catherine Viguié

Publikováno v: HAL
[0] Saisines n° 2018-SA-0126 et 2018-SA-0127, . 2021, 12 p
[0] Saisines n° 2018-SA-0126 et 2018-SA-0127, Anses. 2021, 12 p

Dans le cadre de la procédure d’évaluation des substances prévue par le Règlement REACH n°1907/2006 (articles 44 à 48), les États Membres évaluent chaque année des substances jugées prioritaires, dans le but de clarifier une ou des préoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f3129c1bb4bf55a4f2b0eeecd7c45688
https://hal-anses.archives-ouvertes.fr/anses-03671269