Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ludovic Decultot"'
Autor:
Ludovic Decultot, Stephen Clark
Publikováno v:
Organic letters. 24(41)
Exploration of an ambitious new strategy for the total synthesis of the cytotoxic marine natural product amphidinolide F is described, which features fabrication of the core structure from four readily accessible fragments and macrocycle construction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6932a81628f2e0e2f1d02597a8bc27d
https://pubmed.ncbi.nlm.nih.gov/36223230
https://pubmed.ncbi.nlm.nih.gov/36223230
Publikováno v:
Organic Letters. 22:5594-5599
The natural nucleoside (+)-sinefungin, structurally similar to cofactor S-adenosyl-L-methionine (SAM), inhibits various SAM-dependent methyltransferases (MTs). Access to sinefungin analogues could serve as the basis for the rational design of small-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06a6858d73dca3d6921fc67b30b152a
https://doi.org/10.1021/acs.orglett.0c01956
https://doi.org/10.1021/acs.orglett.0c01956
Publikováno v:
Organic letters. 22(14)
The natural nucleoside (+)-sinefungin, structurally similar to cofactor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8603a0cab08a5ed868a83d2aef8db461
https://pubmed.ncbi.nlm.nih.gov/32628491
https://pubmed.ncbi.nlm.nih.gov/32628491
The natural nucleoside (+)-sinefungin, structurally similar to cofactor S-adenosyl-L-methionine (SAM), inhibits various SAM-dependent methyltransferases (MTs). Access to sinefungin analogues could serve as the basis for the rational design of small-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d33333e0a8ff52e6f3c6f8f48a5e1ee8
https://doi.org/10.26434/chemrxiv.12318797
https://doi.org/10.26434/chemrxiv.12318797
Autor:
Brandon A. Wright, Samuel Carlson, Elizabeth May, Vincent Chu, Petr Kuzmic, Shilpa Rani, Joseph D. Panarese, Rachelle Gaudet, Matthew D. Shair, Sreekanth Dittakavi, Danny T. C. Huang, Rocco L. Policarpo, Saravanakumar Dhakshinamoorthy, Aimo Kannt, Ludovic Decultot
Publikováno v:
J Med Chem
In this work, structure-based rational design led to the development of potent and selective alkynyl bisubstrate inhibitors of NNMT. The reported nicotinamide-SAM conjugate (named NS1) features an alkyne as a key design element that closely mimics th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a04d8b7ae89b4cb800493a0e4df32f6
https://europepmc.org/articles/PMC7955893/
https://europepmc.org/articles/PMC7955893/