Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Ludovic, Collin"'
Autor:
Ming Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt, Janos Paloczi, Avand Amedi, Richard J. B. H. N. van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F. Driever, Bogdan I. Florea, Uwe Grether, Antonius P. A. Janssen, Thomas Hankemeier, Laura H. Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F. Stevens, Daan van der Vliet, Tom van der Wel, Matthias B. Wittwer, Constant A. A. van Boeckel, Pal Pacher, Andrea G. Hohmann, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is limited by central nervous system (CNS)-mediated s
Externí odkaz:
https://doaj.org/article/fdb22352db0b4e3798c8149c29653a5f
Autor:
Helena L. Crowell, Charlotte Soneson, Pierre-Luc Germain, Daniela Calini, Ludovic Collin, Catarina Raposo, Dheeraj Malhotra, Mark D. Robinson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Single-cell transcriptomics enhanced our ability to profile heterogeneous cell populations. It is not known which statistical frameworks are performant to detect subpopulation-level responses. Here, the authors developed a simulation framework to eva
Externí odkaz:
https://doaj.org/article/ca630df4491c4fa29d160b6e84f04cc4
Autor:
Alicia M. Kemble, Benoit Hornsperger, Iris Ruf, Hans Richter, Jörg Benz, Bernd Kuhn, Dominik Heer, Matthias Wittwer, Britta Engelhardt, Uwe Grether, Ludovic Collin
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
Chronic inflammation and blood–brain barrier dysfunction are key pathological hallmarks of neurological disorders such as multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. Major drivers of these pathologies include pro-inflammato
Externí odkaz:
https://doaj.org/article/d34faf86a82540f88518f79cdabc62d6
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3256-3270 (2017)
Transcytosis across the blood-brain barrier (BBB) regulates key processes of the brain, but the intracellular sorting mechanisms that determine successful receptor-mediated transcytosis in brain endothelial cells (BECs) remain unidentified. Here, we
Externí odkaz:
https://doaj.org/article/00a494ec689c41c5a236252d412d480a
Autor:
Yingfang He, Luca C. Gobbi, Adrienne Müller Herde, Didier Rombach, Martin Ritter, Bernd Kuhn, Matthias B. Wittwer, Dominik Heer, Benoit Hornsperger, Charles Bell, Fionn O'Hara, Jörg Benz, Michael Honer, Claudia Keller, Ludovic Collin, Hans Richter, Roger Schibli, Uwe Grether, Linjing Mu
Publikováno v:
Nuclear Medicine and Biology, 108-109
Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays an important role in the endocannabinoid degradation in the brain. It has recently emerged as a promising therapeutic target in the treatment of neuroinflammatory and neurodegenerative d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce52a586caa948df1c940c2253b3a130
https://hdl.handle.net/20.500.11850/536205
https://hdl.handle.net/20.500.11850/536205
Autor:
Will Macnair, Daniela Calini, Eneritz Agirre, Julien Bryois, Sarah Jäkel, Petra Kukanja, Nadine Stokar-Regenscheit, Virginie Ott, Lynette C. Foo, Ludovic Collin, Sven Schippling, Eduard Urich, Erik Nutma, Manuel Marzin, Sandra Amor, Roberta Magliozzi, Elyas Heidari, Mark D. Robinson, Charles ffrench-Constant, Gonçalo Castelo-Branco, Anna Williams, Dheeraj Malhotra
The lack of understanding as to the cellular and molecular basis of clinical and genetic heterogeneity in progressive multiple sclerosis (MS) has hindered the search for new effective therapies and biomarkers. Here, to address this gap, we analysed 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82ac11ba9c2fd8f4a2ebc946257f7694
https://doi.org/10.1101/2022.04.06.487263
https://doi.org/10.1101/2022.04.06.487263
Autor:
Yingfang He, Matthias Schild, Uwe Grether, Jörg Benz, Lea Leibrock, Dominik Heer, Andreas Topp, Ludovic Collin, Bernd Kuhn, Matthias Wittwer, Claudia Keller, Luca C. Gobbi, Roger Schibli, Linjing Mu
Publikováno v:
Journal of medicinal chemistry. 65(3)
Monoacylglycerol lipase (MAGL) is one of the key enzymes in the endocannabinoid system. Inhibition of MAGL has been proposed as an attractive approach for the treatment of various diseases. In this study, we designed and successfully synthesized two
Autor:
Yingfang He, Uwe Grether, Marco F. Taddio, Carla Meier, Claudia Keller, Martin R. Edelmann, Michael Honer, Sylwia Huber, Matthias B. Wittwer, Dominik Heer, Hans Richter, Ludovic Collin, Melanie N. Hug, Manuel Hilbert, Annemarieke G.J. Postmus, Anna Floor Stevens, Mario van der Stelt, Stefanie D. Krämer, Roger Schibli, Linjing Mu, Luca C. Gobbi
Publikováno v:
European Journal of Medicinal Chemistry, 243:114750. ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
European Journal of Medicinal Chemistry, 243
European Journal of Medicinal Chemistry, 243
Monoacylglycerol lipase (MAGL) is a gatekeeper in regulating endocannabinoid signaling and has gained substantial attention as a therapeutic target for neurological disorders. We recently discovered a morpholin-3-one derivative as a novel scaffold fo
Publikováno v:
International Journal of Antennas and Propagation, Vol 2015 (2015)
In multiple-input multiple-output (MIMO) transmission systems, the channel state information (CSI) at the transmitter can be used to add linear precoding to the transmitted signals in order to improve the performance and the reliability of the transm
Externí odkaz:
https://doaj.org/article/51969b5695d84c7fb1c49804cbbd292b
Publikováno v:
Cellular and Molecular Life Sciences
The blood-brain barrier is a dynamic multicellular interface that regulates the transport of molecules between the blood circulation and the brain parenchyma. Proteins and peptides required for brain homeostasis cross the blood-brain barrier via tran