Výsledky vyhledávání - "Ludo A. M. Broos"

Distinguishing core from penumbra by lipid profiles using Mass Spectrometry Imaging in a transgenic mouse model of ischemic stroke

Autor: N. Ogrinc Potočnik, Marieke J.H. Wermer, Ron M. A. Heeren, A.M.J.M. van den Maagdenberg, Arnoud Prop, Inge A. Mulder, Ludo A. M. Broos

Publikováno v: Scientific Reports, 9
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1090), ⟨10.1038/s41598-018-37612-5⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, 9:1090, 1-10. Nature Publishing Group

Detecting different lipid profiles in early infarct development may give an insight on the fate of compromised tissue. Here we used Mass Spectrometry Imaging to identify lipids at 4, 8 and 24 hours after ischemic stroke in mice, induced by transient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329bf53d95b11dcc997067e437c1c1f0
https://hdl.handle.net/1887/119753

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Cortical Spreading Depression Causes Unique Dysregulation of Inflammatory Pathways in a Transgenic Mouse Model of Migraine

Autor: Ahmed Mahfouz, Boukje de Vries, Else Eising, Else A. Tolner, Michel D. Ferrari, Arn M. J. M. van den Maagdenberg, Marcel J. T. Reinders, Peter A C 't Hoen, Lisanne S. Vijfhuizen, Sjoerd M. H. Huisman, Ludo A. M. Broos, Reinald Shyti

Publikováno v: Molecular neurobiology, 54(4), 2986-2996
Molecular Neurobiology
Molecular Biology
Molecular neurobiology
Molecular Neurobiology, 54(4)
Molecular Neurobiology, 54(4), 2986-2996

Familial hemiplegic migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by mutations in CACNA1A that encodes the α1A subunit of voltage-gated CaV2.1 calcium channels. Transgenic knock-in mice that carry the human FHM1 R19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5221eded4465a1ddced7142d69a6d8
http://www.scopus.com/inward/record.url?eid=2-s2.0-84962157660∂nerID=MN8TOARS

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RNA expression profiling in brains of familial hemiplegic migraine type 1 knock-in mice

Autor: Arn M. J. M. van den Maagdenberg, Boukje de Vries, Stephany C. Koelewijn, Boyan Todorov, Peter A C 't Hoen, Else Eising, Rune R. Frants, Ludo A. M. Broos, Judith M. Boer, Michel D. Ferrari

Publikováno v: Cephalalgia
Cephalalgia, 34(3), 174-182

Background Various CACNA1A missense mutations cause familial hemiplegic migraine type 1 (FHM1), a rare monogenic subtype of migraine with aura. FHM1 mutation R192Q is associated with pure hemiplegic migraine, whereas the S218L mutation causes hemiple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97cb06a83ccdcd9a2af328509da13eae
https://doi.org/10.1177/0333102413502736

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The NOTCH3 score: a pre-clinical CADASIL biomarker in a novel human genomic NOTCH3 transgenic mouse model with early progressive vascular NOTCH3 accumulation

Autor: Arn M. J. M. van den Maagdenberg, Annemieke Aartsma-Rus, Saskia A J Lesnik Oberstein, J. Sjef Verbeek, Ludo A. M. Broos, Louise van der Weerd, Hans G. Dauwerse, Cor Breukel, Roselin R. Klever, Dana S. Poole, Julie W. Rutten, Sjoerd G. van Duinen, Ingrid M Hegeman

Publikováno v: Acta Neuropathologica Communications
Acta Neuropathologica Communications, 3

Introduction CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary small vessel disease caused by mutations in the NOTCH3 gene, leading to toxic NOTCH3 protein accumulation in the small-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e207269b1a9460f2c28372d94e6b02
https://doi.org/10.1186/s40478-015-0268-1

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Neuropathophysiological potential of Guillain-Barré syndrome anti-ganglioside-complex antibodies at mouse motor nerve terminals

Autor: Bart C. Jacobs, Femke M.P. Zitman, Hugh J. Willison, Jaap J. Plomp, Susumu Kusunoki, Kenichi Kaida, Mark L. Kuijf, Masami Ueda, Anne P. Tio-Gillen, Kay N. Greenshields, Ludo A. M. Broos

Publikováno v: Clinical and Experimental Neuroimmunology. 2:59-67

Objectives: Anti-ganglioside antibodies are present in approximately half of Guillain–Barre syndrome (GBS) patients. Recently, it has been shown that a considerable proportion of these patients has serum antibodies against antigenic epitopes formed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47fa52d88ff2e42c8791d9187adc90c0
https://doi.org/10.1111/j.1759-1961.2011.00022.x

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Gene dosage-dependent transmitter release changes at neuromuscular synapses of Cacna1a R192Q knockin mice are non-progressive and do not lead to morphological changes or muscle weakness

Autor: M. D. Ferrari, Jaap J. Plomp, A.M.J.M. van den Maagdenberg, Rune R. Frants, Jan J.G.M. Verschuuren, Ludo A. M. Broos, R.C.G. van de Ven, Simon Kaja, J.G. van Dijk, H.A.P. Veldman

Publikováno v: Neuroscience. 135:81-95

Ca(v)2.1 channels mediate neurotransmitter release at the neuromuscular junction (NMJ) and at many central synapses. Mutations in the encoding gene, CACNA1A, are thus likely to affect neurotransmitter release. Previously, we generated mice carrying t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b21faa9f7cb20f61ceb5b7c655f2e8
https://doi.org/10.1016/j.neuroscience.2005.04.069

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Familial Hemiplegic Migraine Type 1 Mutations K1336E, W1684R, and V1696I Alter Cav2.1 Ca2+ Channel Gating

Autor: Arn M. J. M. van den Maagdenberg, Jörg Striessnig, Carmen Müllner, Ludo A. M. Broos

Publikováno v: Journal of Biological Chemistry. 279:51844-51850

Mutations in the Cav2.1 alpha1-subunit of P/Q-type Ca2+ channels cause human diseases, including familial hemiplegic migraine type-1 (FHM1). FHM1 mutations alter channel gating and enhanced channel activity at negative potentials appears to be a comm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bcebc3b5f3881a87f4b14d8cbb68e7d
https://doi.org/10.1074/jbc.m408756200

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Severe and Progressive Neurotransmitter Release Aberrations in Familial Hemiplegic Migraine Type 1 Cacna1a S218L Knock-in Mice

Autor: Simon Kaja, Rune R. Frants, Jaap J. Plomp, Arn M. J. M. van den Maagdenberg, Ludo A. M. Broos, Michel D. Ferrari, Rob C. G. van de Ven

Publikováno v: Journal of Neurophysiology, 104(3), 1445-1455

Kaja S, Van de Ven RCG, Broos LAM, Frants RR, Ferrari MD, Van den Maagdenberg AMJM, Plomp JJ. Severe and progressive neurotransmitter release aberrations in familial hemiplegic migraine type 1 Cacna1a S218L knock-in mice. J Neurophysiol 104: 1445-145

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f46429dad5e2e197d3977af7380703
https://doi.org/10.1152/jn.00012.2010

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Quantitative cortical synapse proteomics of a transgenic migraine mouse model with mutated Ca(V)2.1 calcium channels

Autor: Arn M. J. M. van den Maagdenberg, Oleg A. Mayboroda, Michel D. Ferrari, Igor A. Sidorov, Oleg I. Klychnikov, André M. Deelder, Maarten Loos, Ludo A. M. Broos, Ka Wan Li, Rune R. Frants, August B. Smit, Sabine Spijker

Publikováno v: Klychnikov, O I, Li, K W, Sidorov, I A, Loos, M, Spijker, S, Broos, L A M, Frants, R R, Ferrari, M D, Mayboroda, O A, Deelder, A M, Smit, A B & van den Maagdenberg, A M J M 2010, ' Quantitative cortical synapse proteomics of a transgenic migraine mouse model with mutated Ca(v)2.1 calcium channels ', Journal of Proteomics, vol. 10, no. 13, pp. 2531-2535 . https://doi.org/10.1002/pmic.200900733
Proteomics, 10(13), 2531-2535
Journal of Proteomics, 10(13), 2531-2535. Elsevier

Familial hemiplegic migraine type 1 (FHM1) is caused by missense mutations in the CACNA1A gene that encodes the alpha1A pore-forming subunit of Ca(V)2.1 Ca(2+) channels. Knock-in (KI) transgenic mice expressing Ca(V)2.1 Ca(2+) channels with a human p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58566c365590793b647b6ae320c4e394
https://pubmed.ncbi.nlm.nih.gov/20391530

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