Statin use is associated with a reduced incidence of colorectal cancer expressing SMAD4

Autor: Tom van Wezel, Ron M. C. Herings, Britt van Vliet, Lukas J. A. C. Hawinkels, James C. H. Hardwick, Rutger J. Jacobs, Ludmilla L. Kodach, Philip W. Voorneveld, Sarah Ouahoud, Hans Morreau, Marije Slingerland, Esther Bastiaannet, Hein Putter, Nikki L. Weil, Lennart R A van der Burg

Publikováno v: Ouahoud, S, Jacobs, R J, Kodach, L L, Voorneveld, P W, Hawinkels, L J A C, Weil, N L, van Vliet, B, Herings, R M, van der Burg, L R A, van Wezel, T, Morreau, H, Slingerland, M, Bastiaannet, E, Putter, H & Hardwick, J C H 2022, ' Statin use is associated with a reduced incidence of colorectal cancer expressing SMAD4 ', British Journal of Cancer, vol. 126, no. 2, pp. 297-301 . https://doi.org/10.1038/s41416-021-01604-6
British Journal of Cancer. SPRINGERNATURE
British Journal of Cancer
British Journal of Cancer, 126(2), 297-301. Nature Publishing Group
Br J Cancer

BACKGROUND: Long-term use of statins is associated with a small reduced risk of colorectal cancer but their mechanism of action is not well understood. While they are generally believed to act on KRAS, we have previously proposed that they act via in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee94a4827fa764a30634a966aa9f83e
https://hdl.handle.net/1887/3264145

Cholesterol metabolism and colorectal cancers

Autor: Ludmilla L. Kodach, James C. H. Hardwick, Philip W. Voorneveld, Rutger J. Jacobs

Publikováno v: Current Opinion in Pharmacology, 12(6), 690-695

Colorectal cancer (CRC) is primarily a lifestyle disease of the western world. As such it can be likened to cardiovascular disease and indeed it shares many of the same risk factors. It is therefore perhaps unsurprising that cholesterol metabolism an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf44e941479d3e5e5c47b0cf44d8f1f0
https://hdl.handle.net/1887/106361