Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Ludmila M, Savchenko"'
1
Off-label antipsychotics prescription to adolescents with acute psychotic episodes does not cause adverse drug reactions
Autor: N. I. Buromskaya, Ludmila M. Savchenko, N. A. Tsarkova, Yu. S. Shevchenko, Dmitriy A. Sychev, A. D. Malakhova, D. V. Ivashchenko
Publikováno v: Nevrologiâ, Nejropsihiatriâ, Psihosomatika, Vol 13, Iss 3, Pp 19-26 (2021)
Antipsychotics are often used to treat children and adolescents. Because of their age, there are a lot of off-label prescribed antipsychotics in that population. However, the off-label use of medications is considered to be potentially unsafe.Objecti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23fea16048d7bbcfa69fdf93735ca3c6
https://nnp.ima-press.net/nnp/article/view/1569
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2
Efficacy and safety of antipsychotics in adolescents with an acute psychotic episode in relation to the activity of CYP3A and CYP2D6 isoenzymes
Autor: N. I. Buromskaya, A. A. Kachanova, Ludmila M. Savchenko, Roman V. Deitch, A. S. Osipov, D. V. Ivashchenko, Yu. S. Shevchenko, K. A. Akmalova, Dmitriy A. Sychev, E. N. Shagovenko, V. V. Smirnov, P. V. Shimanov, E. V. Nazarova, M. A. Ovchinnikova, T. A. Fainshtein, Elena A. Grishina
Publikováno v: Nevrologiâ, Nejropsihiatriâ, Psihosomatika, Vol 12, Iss 6, Pp 11-18 (2020)
Antipsychotics are a first-line treatment for psychotic disorders. The cytochrome P450 isoenzymes CYP3A4/5 and CYP2D6 metabolize most antipsychotics. The activity of these isoenzymes in children changes with maturation, so it is different from that i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a67d62c5efa9f250eeda3b1c3e832a
https://doi.org/10.14412/2074-2711-2020-6-11-18
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3
The polymorphic variants DRD2 rs1800497 and ABCB1 3435C>T are associated with antipsychotic safety parameters in adolescents with an acute psychotic episode: the results of a pilot study
Autor: Roman V. Deitch, Yu. S. Shevchenko, Irina V. Dorina, Ludmila M. Savchenko, S. Z. Khoang, P. V. Shimanov, Dmitry A. Sychev, M. Kh. Tazagulova, K. A. Akmalova, B. V. Makhmudova, N. I. Buromskaya, A. A. Kachanova, Elena A. Grishina, D. V. Ivashchenko, Marina I. Nastovich
Publikováno v: Nevrologiâ, Nejropsihiatriâ, Psihosomatika, Vol 12, Iss 5, Pp 24-31 (2020)
Children and adolescents are more likely than adults to experience adverse side effects when taking antipsychotics. Pharmacogenetic testing allows one to more accurately choose the initial dose of a drug. The genes of pharmacokinetic factors have bee
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57459463aa0ca27a70e06fbfa1f65267
https://doi.org/10.14412/2074-2711-2020-5-24-31
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5
Pharmacogenetics of the safety of phenazepam in alcohol withdrawal syndrome: haplotype and combinatorial analyses of polymorphic variants in the pharmacokinetic factor genes
Autor: Elena A. Grishina, I. I. Temirbulatov, Mikhail Sergeevich Zastrozhin, D. V. Ivashchenko, O. V. Tereshchenko, Ludmila M. Savchenko, Dmitry A. Sychev, E. A. Bryun, K. A. Akmalova
Publikováno v: Nevrologiâ, Nejropsihiatriâ, Psihosomatika, Vol 12, Iss 2, Pp 17-22 (2020)
Phenazepam is a benzodiazepine tranquilizer that is widely used in Russia. The drug is metabolized by cytochrome P450 3A (CYP3A) isozymes. Since their substrates have an affinity for P-glycoprotein, the polymorphic variants in the ABCB1 gene may affe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0520f37e0c86e4b089c1117273984e41
https://doi.org/10.14412/2074-2711-2020-2-17-22
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6
The Effect of Cyp2d6 Gene Polymorphism on the Efficacy and Safety of Mirtazapine in Patients with Depressive Disorders Comorbid with Alcohol
Autor: Sergey S. Koporov, E. A. Bryun, Mikhail Sergeevich Zastrozhin, Alexander S. Sorokin, Elena A. Grishina, Kristina A Ryzhikova, Valery V. Smirnov, Dmitry A. Sychev, Valery V. Shipitsyn, Ludmila M. Savchenko, Oleg Z. Buzik
Publikováno v: Annals of the Russian academy of medical sciences. 74:185-191
Background: Alcohol dependence is often combined with affective disorders, in particular, depressive disorder, which adversely affects the prognosis of the course of both diseases. For the treatment of a depressive disorder, drugs from the group of t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::201f8d55f520634ce0d554b5170676e2
https://doi.org/10.15690/vramn1075
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8
Effects of CYP2C19*2 polymorphisms on the efficacy and safety of phenazepam in patients with anxiety disorder and comorbid alcohol use disorder
Autor: Kristina A Ryzhikova, Michael S. Zastrozhin, Inessa A. Bedina, Egor Chumakov, Dmitry A. Sychev, Anastasiya Petrovna, Evgeny A Brun, Alexander S. Sorokin, Valentin Yurievich Skryabin, Ludmila M. Savchenko, Oleg Z. Buzik, Marco Torrado, Elena A. Grishina
Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
© 2020 Future Science Group.
Introduction: Phenazepam therapy can often be ineffective and some patients develop dose-related adverse drug reactions. Aim. The purpose of this research was to study the effect of the CYP2C19*2 (681G>A, rs4244285)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5eb2c1deed43940a83f8b176b44d928
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9
Effects of CYP2C19*17 polymorphisms on the efficacy and safety of bromodigyrochlorophenylbenzodiazepine in patients with anxiety disorder and comorbid alcohol use disorder
Autor: Elena V. Nesterenko, Dmitry A. Sychev, E. A. Grishina, Ludmila M. Savchenko, Antonina P. Esakova, Leyla I. Seyfullaeva, Violetta R. Mustafina, Alexandr S. Sorokin, E. A. Bryun, Valentin Yu Skryabin, Michael S. Zastrozhin, Anastasiya P. Antonenko
Publikováno v: Drug Metabolism and Personalized Therapy. 33:187-194
Background Bromodihydrochlorophenylbenzodiazepine (Phenazepam®) is used in the therapy of anxiety disorders in patients with alcohol dependence. However, Phenazepam therapy often turns out to be ineffective, and some patients develop dose-related ad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f257de009fc157624145fe83e7675212
https://doi.org/10.1515/dmpt-2018-0019
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10
Influence of CYP3A Activity on the Efficacy and Safety of Fluvoxamine in Patients Depressive Disorders and Comorbid Alcohol Use Disorder
Autor: Dmitry A. Sychev, Mikhail Sergeevich Zastrozhin, Kristina A Ryzhikova, Ludmila M. Savchenko, Elena A. Grishina, Oleg Z. Buzik, Alexander S. Sorokin, Valery V. Shipitsyn, Evgeny А. Bryun, Inessa A. Bedina, Valery V. Smirnov, Sergey S. Koporov
Publikováno v: Annals of the Russian academy of medical sciences. 73:411-419
Background: Alcohol dependence is often combined with affective disorders, in particular, depressive disorder (DD), which worsens adversely affects the prognosis of the course of both diseases and their outcomes. For the treatment of DD, drugs from t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc8f69714edb15c1ba3d91b53f405a6f
https://doi.org/10.15690/vramn1035
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