Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ludmila Kazdová"'
Autor:
Jan Silhavy, Petr Mlejnek, Miroslava Šimáková, Irena Marková, Hana Malínská, Martina Hüttl, Ludmila Kazdová, Dmitry Kazantsev, Massimiliano Mancini, Jiří Novotný, Michal Pravenec
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283276 (2023)
Thermogenesis in brown adipose tissue (BAT) uses intracellular triglycerides, circulating free fatty acids and glucose as the main substrates. The objective of the current study was to analyse the role of CD36 fatty acid translocase in regulation of
Externí odkaz:
https://doaj.org/article/35b76587320949d6a94477eed4b50a5f
Autor:
Jan Šilhavý, Petr Mlejnek, Miroslava Šimáková, Hana Malínská, Irena Marková, Martina Hüttl, Denisa Miklánková, Ludmila Kazdová, Marek Vrbacký, Alena Pecinová, Tomáš Mráček, Michal Pravenec
Publikováno v:
Metabolites, Vol 13, Iss 2, p 192 (2023)
Recently, red beetroot has attracted attention as a health-promoting functional food. Studies have shown that beetroot administration can reduce blood pressure and ameliorate parameters of glucose and lipid metabolism; however, mechanisms underlying
Externí odkaz:
https://doaj.org/article/a687dbf6a0cc4fd38db94b4d81c78b08
Autor:
Jan Šilhavý, Hana Malínská, Martina Hüttl, Irena Marková, Olena Oliyarnyk, Petr Mlejnek, Miroslava Šimáková, František Liška, Ludmila Kazdová, Radka Moravcová, Jiří Novotný, Michal Pravenec
Publikováno v:
Antioxidants, Vol 9, Iss 12, p 1179 (2020)
Methylglyoxal (MG), a potent precursor of advanced glycation end-products (AGE), is increased in metabolic disorders such as diabetes and obesity. MG and other dicarbonyl metabolites are detoxified by the glyoxalase system in which glyoxalase 1, code
Externí odkaz:
https://doaj.org/article/126578c8b040440fba45cd5f441464c1
Single-Gene Congenic Strain Reveals the Effect of Zbtb16 on Dexamethasone-Induced Insulin Resistance
Autor:
Michaela Krupková, František Liška, Ludmila Kazdová, Lucie Šedová, Adéla Kábelová, Drahomíra Křenová, Vladimír Křen, Ondřej Šeda
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
BackgroundGlucocorticoids (GCs) are potent therapeutic agents frequently used for treatment of number of conditions, including hematologic, inflammatory, and allergic diseases. Both their therapeutic and adverse effects display significant interindiv
Externí odkaz:
https://doaj.org/article/9c7cdc0d50c44b5db42f54f46828053e
Autor:
Jaroslava Trnovská, Jan Šilhavý, Ondřej Kuda, Vladimír Landa, Václav Zídek, Petr Mlejnek, Miroslava Šimáková, Hynek Strnad, Vojtěch Škop, Olena Oliyarnyk, Ludmila Kazdová, Martin Haluzík, Michal Pravenec
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179063 (2017)
Chronic low-grade inflammation plays an important role in the pathogenesis of insulin resistance. In the current study, we tested the effects of salsalate, a non-steroidal anti-inflammatory drug, in an animal model of inflammation and metabolic syndr
Externí odkaz:
https://doaj.org/article/8f616313fe6841dd9e8fec56bd41364a
Autor:
Hana Malínská, Olena Oliyarnyk, Vojtěch Škop, Jan Šilhavý, Vladimír Landa, Václav Zídek, Petr Mlejnek, Miroslava Šimáková, Hynek Strnad, Ludmila Kazdová, Michal Pravenec
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150924 (2016)
Inflammation and oxidative and dicarbonyl stress play important roles in the pathogenesis of type 2 diabetes. Metformin is the first-line drug of choice for the treatment of type 2 diabetes because it effectively suppresses gluconeogenesis in the liv
Externí odkaz:
https://doaj.org/article/e7088f4bdc484766897a5d24bbf99102
Autor:
Lucie Šedová, Michal Pravenec, Drahomíra Křenová, Ludmila Kazdová, Václav Zídek, Michaela Krupková, František Liška, Vladimír Křen, Ondřej Šeda
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152708 (2016)
Metabolic syndrome is a highly prevalent human disease with substantial genomic and environmental components. Previous studies indicate the presence of significant genetic determinants of several features of metabolic syndrome on rat chromosome 16 (R
Externí odkaz:
https://doaj.org/article/0157da71515941e68e4923ba903ef77c
Autor:
Vojt ch Škop, Hana Malínská, Jaroslava Trnovská, Martina Hüttl, Monika Cahová, Agnieszka Blachnio-Zabielska, Marcin Baranowski, Martin Burian, Olena Oliyarnyk, Ludmila Kazdová
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122768 (2015)
While metabolic syndrome is often associated with obesity, 25% of humans suffering from it are not obese and the effect of physical activity remains unclear in such cases. Therefore, we used hereditary hypertriaclyglycerolemic (HHTg) rats as a unique
Externí odkaz:
https://doaj.org/article/1b55067b45e14fe1955b476df6722118
Autor:
Jan Šilhavý, Václav Zídek, Petr Mlejnek, Vladimír Landa, Miroslava Šimáková, Hynek Strnad, Olena Oliyarnyk, Vojtěch Škop, Ludmila Kazdová, Theodore Kurtz, Michal Pravenec
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101906 (2014)
Inflammation and oxidative stress have been implicated in the pathogenesis of metabolic disturbances. Esters of fumaric acid, mainly dimethyl fumarate, exhibit immunomodulatory, anti-inflammatory, and anti-oxidative effects. In the current study, we
Externí odkaz:
https://doaj.org/article/b16d4dfa433643c6a5a87dd3b2f7e631
Autor:
Miloslava Hodúlová, Lucie Šedová, Drahomíra Křenová, František Liška, Michaela Krupková, Ludmila Kazdová, Johanne Tremblay, Pavel Hamet, Vladimír Křen, Ondřej Šeda
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109983 (2014)
The plasma profile of major lipoprotein classes and its subdivision into particular fractions plays a crucial role in the pathogenesis of atherosclerosis and is a major predictor of coronary artery disease. Our aim was to identify genomic determinant
Externí odkaz:
https://doaj.org/article/159e50355c3f48659abb1bfaf04845ec