Immunogenicity and Protective Activity of a Chimeric Protein Based on the Domain III of the Tick-Borne Encephalitis Virus E Protein and the OmpF Porin of Yersinia pseudotuberculosis Incorporated into the TI-Complex

Autor: Nina Sanina, Natalia Chopenko, Andrey Mazeika, Ludmila Davydova, Galina Leonova, Anna Stenkova, Vladimir N. Uversky, Eduard Kostetsky

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 10, p 2988 (2018)

Tick-borne encephalitis (TBE) is a widespread, dangerous infection. Unfortunately, all attempts to create safe anti-TBE subunit vaccines are still unsuccessful due to their low immunogenicity. The goal of the present work was to investigate the immun

Externí odkaz: https://doaj.org/article/b03ddc969bed44608e5d1fdaeaf83911

Modulation of Immunogenicity and Conformation of HA1 Subunit of Influenza A Virus H1/N1 Hemagglutinin in Tubular Immunostimulating Complexes

Autor: Nina Sanina, Ludmila Davydova, Natalia Chopenko, Eduard Kostetsky, Valery Shnyrov

Publikováno v: International Journal of Molecular Sciences, Vol 18, Iss 9, p 1895 (2017)

The HA1 subunit of the influenza virus hemagglutinin (HA) is a valuable antigen for the development of vaccines against flu due to the availability of most antigenic sites which are conformational. Therefore, a novel adjuvanted antigen delivery syste

Externí odkaz: https://doaj.org/article/ff62be5f11cf404ca96b7a8cb958708d

Lipid-induced changes in protein conformation as a means to regulate the immunogenicity of antigens incorporated in tubular immunostimulating complexes

Autor: Natalia S. Vorobieva, O. Yu. Portniagina, Valery L. Shnyrov, Olga D. Novikova, Ludmila Davydova, E. Ya. Kostetsky, Nina M. Sanina

Publikováno v: Biophysics. 61:380-386

Nanoparticles of tubular immunostimulating complexes (TI-complexes), which consist of the glycolipid monogalactosyldiacylglycerol (MGDG) from marine macrophytes (macroalgae and seagrasses), the triterpene glycoside cucumarioside A2-2 from the holothu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40402a1ea5bbef85b30c5aee570327ec
https://doi.org/10.1134/s0006350916030155

Recombinant Fusion Protein Joining E Protein Domain III of Tick-Borne Encephalitis Virus and HSP70 of Yersinia pseudotuberculosis as an Antigen for the TI-Complexes

Autor: Vladimir N. Uversky, Andrey N Mazeika, Ludmila Davydova, Eduard Y. Kostetsky, Vasily Golotin, Nina M. Sanina, Valery L. Shnyrov, Manuel G. Roig, Natalia Chopenko

Publikováno v: Biomolecules
Volume 8
Issue 3
Biomolecules, Vol 8, Iss 3, p 82 (2018)

Domain III (DIII) of the tick-borne encephalitis virus (TBEV) protein E contains epitopes, which induce antibodies capable of neutralizing the virus. To enhance the immunogenicity of this protein, which has a low molecular weight, the aim of the pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b438036c6dcc3f4497d52e4000bf562b

Modulation of Immunogenicity and Conformation of HA1 Subunit of Influenza A Virus H1/N1 Hemagglutinin in Tubular Immunostimulating Complexes

Autor: Eduard Y. Kostetsky, Nina M. Sanina, Valery L. Shnyrov, Ludmila Davydova, Natalia Chopenko

Publikováno v: International Journal of Molecular Sciences; Volume 18; Issue 9; Pages: 1895
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 9, p 1895 (2017)

The HA1 subunit of the influenza virus hemagglutinin (HA) is a valuable antigen for the development of vaccines against flu due to the availability of most antigenic sites which are conformational. Therefore, a novel adjuvanted antigen delivery syste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ac55428b29890a57b1f0c709dfbc7f