Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ludmila A. Voloboueva"'
Publikováno v:
Mitochondrion
Brain-enriched microRNA-338 (miR-338) is known to play a central role in brain mitochondrial function, however the role of miR-338 in stroke injury remains unknown. This study investigated the role of miR-338 in injury from transient focal cerebral i
Publikováno v:
The Journal of Neuroscience. 37:3072-3084
Neurogenesis is essential to brain development and plays a central role in the response to brain injury. Stroke and head trauma stimulate proliferation of endogenous neural stem cells (NSCs); however, the survival of young neurons is sharply reduced
Publikováno v:
Journal of Neuroscience Research. 93:1703-1712
Recent studies have demonstrated that neural stem cell (NSC) culture at physiologically normoxic conditions (2-5% O2) is advantageous in terms of neuronal differentiation and survival. Neuronal differentiation is accompanied by a remarkable shift to
Autor:
Ludmila A. Voloboueva, Rona G. Giffard
Publikováno v:
Journal of Neuroscience Research. 89:1989-1996
The process of neurogenesis continues throughout life, with thousands of new neurons generated every day in the mammalian brain. Impairment of hippocampal neurogenesis has been suggested to be involved in neurodegenerative conditions, including the c
Publikováno v:
Glia. 58:1042-1049
Brief forebrain ischemia is a model of the delayed hippocampal neuronal loss seen in patients following cardiac arrest and resuscitation. Previous studies demonstrated that selective dysfunction of hippocampal CA1 subregion astrocytes occurs hours to
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 29:365-374
Mitochondria are known to be central to the cell's response to ischemia, because of their role in energy generation, in free radical generation, and in the regulation of apoptosis. Heat shock protein 75 (Hsp75/Grp75/mortalin/TRAP1) is a member of the
Autor:
Yi-Bing Ouyang, Christian Stoy, Rona G. Giffard, Melissa Duan, John F. Emery, Ludmila A. Voloboueva
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 28:1009-1016
Mitochondrial heat shock protein 70 (mtHsp70/Hsp75/Grp75/mortalin/TRAP-1/PBP74) is an essential mitochondrial chaperone and a member of the heat shock protein 70 (HSP70) family. Although many studies have shown the protective properties of overexpres
Publikováno v:
Journal of Neurochemistry. 102:1383-1394
Much evidence suggests that astrocytes protect neurons against ischemic injury. Although astrocytes are more resistant to some insults than neurons, few studies offer insight into the real time changes of astrocytic protective functions with stress.
Publikováno v:
The FASEB Journal. 21:4077-4086
Age-related macular degeneration (AMD) is the leading cause of severe visual impairment in the elderly in developed countries. AMD patients have elevated levels of iron within the retinal pigment epithelia (RPE), which may lead to oxidative damage to
Publikováno v:
Journal of neuroscience research. 93(11)
Recent studies have demonstrated that neural stem cell (NSC) culture at physiologically normoxic conditions (2-5% O2) is advantageous in terms of neuronal differentiation and survival. Neuronal differentiation is accompanied by a remarkable shift to