Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ludivine Zoute"'
Autor:
Graeme L. Fraser, Ludivine Zoute, Sarah Rorive, Didier Schils, Alexey Lapin, Sébastien Blanc, Hamid R. Hoveyda, Jerrold M. Olefsky, Jérôme Bernard, Cyrille Evangelos Brantis, Sandrine Hospied, Sandra Guitard, François Lenoir, Joanne C. McNelis, Frédéric Ooms, Julien Parcq, Mohamed El Bousmaqui, Guillaume Dutheuil
Publikováno v:
Bioorganicmedicinal chemistry. 26(18)
Free fatty acid-2 (FFA2) receptor is a G-protein coupled receptor of interest in the development of therapeutics in metabolic and inflammatory disease areas. The discovery and optimization of an N-thiazolylamide carboxylic acid FFA2 agonist scaffold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cf904392158b74989b778d54dae4af
https://pubmed.ncbi.nlm.nih.gov/30253886
https://pubmed.ncbi.nlm.nih.gov/30253886
Publikováno v:
The Journal of Organic Chemistry. 74:4124-4131
A efficient methodology allowing the one-pot stereoselective synthesis of alpha-fluoroacrylates, based on the addition of ethyl dibromofluoroacetate to a carbonyl derivative using diethylzinc as organometallic mediator, is described. Two different pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b876e8c9d3f14a7efd657dca0572c6
https://doi.org/10.1021/jo900422m
https://doi.org/10.1021/jo900422m
Publikováno v:
Tetrahedron Letters. 47:7931-7933
α-Fluoro-α,β-unsaturated esters 2 were efficiently synthetized via diethylzinc-promoted Wittig reaction using a phosphonium-supported triphenylphosphine SCG–PPh3 1, which possesses similar reactivity as its parent analog triphenylphosphine. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f490ac13960614c687c949936f30ef5
https://doi.org/10.1016/j.tetlet.2006.09.008
https://doi.org/10.1016/j.tetlet.2006.09.008
Publikováno v:
ChemInform. 42
A one-step method is developed to prepare the target molecules starting from carbonyl compounds and dibromofluoroacetate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98ebae92cb85e76167498a4d447605b5
https://doi.org/10.1002/chin.201132066
https://doi.org/10.1002/chin.201132066
Publikováno v:
Tetrahedron Letters
Tetrahedron Letters, Elsevier, 2011, 52 (19), pp.2473-2475. ⟨10.1016/j.tetlet.2011.03.014⟩
Tetrahedron Letters, Elsevier, 2011, 52 (19), pp.2473-2475. ⟨10.1016/j.tetlet.2011.03.014⟩
International audience; A Reformatsky-type addition of ethyl dibromofluoroacetate associated with diethylzinc to various carbonyl compounds is described. Aldehydes, ketones and lactones were converted into the corresponding α-bromo-α-fluoro-β-hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67765f84ce75b2a61c7214d9e3bb2a87
https://hal.archives-ouvertes.fr/hal-01017744
https://hal.archives-ouvertes.fr/hal-01017744
Publikováno v:
ChemInform. 41
Treatment of various ketones with ethyl dibromofluoroacetate in the presence of diethylzinc and dimethylaminoethanol or triphenylphosphine provides rapid access to corresponding fluorinated glycidic esters. Simplified workup allowed first characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc151f4157592174ac1537a108cf8746
https://doi.org/10.1002/chin.201025074
https://doi.org/10.1002/chin.201025074
Publikováno v:
Organic Letters
Organic Letters, American Chemical Society, 2010, 12 (4), pp.844-846. ⟨10.1021/ol902903v⟩
Organic Letters, American Chemical Society, 2010, 12 (4), pp.844-846. ⟨10.1021/ol902903v⟩
International audience; Treatment of various ketones with ethyl dibromofluoroacetate in the presence of diethylzinc and dimethylaminoethanol or triphenylphosphine provides rapid access to corresponding fluorinated glycidic esters. Simplified workup a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec55dc667f882821fb9acbc943b61e0a
https://pubmed.ncbi.nlm.nih.gov/20095572
https://pubmed.ncbi.nlm.nih.gov/20095572
Publikováno v:
ChemInform. 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ddcbbb506b7c4bf7be5f1f0e9c13403
https://doi.org/10.1002/chin.200945124
https://doi.org/10.1002/chin.200945124
Publikováno v:
ChemInform. 40
A efficient methodology allowing the one-pot stereoselective synthesis of α-fluoroacrylates, based on the addition of ethyl dibromofluoroacetate to a carbonyl derivative using diethylzinc as organometallic mediator, is described. Two different pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::043d10dc89c47ad0d1314c766cc37c83
https://doi.org/10.1002/chin.200943053
https://doi.org/10.1002/chin.200943053
Publikováno v:
Organic letters. 11(12)
The rhodium-catalyzed 1,4-addition of arylboronic acids to an enantiopure heterocyclic acceptor proceeds under ligand control to effect an asymmetric synthesis of functionalized pyrrolizidinones. The protocol allows convenient access to all four ster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee35c95bd509af36700954035b54d33
https://pubmed.ncbi.nlm.nih.gov/19462943
https://pubmed.ncbi.nlm.nih.gov/19462943