Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ludivine Le Dret"'
Autor:
Virginie Menez, Thomas Kergrohen, Tal Shasha, Claudia Silva-Evangelista, Ludivine Le Dret, Lucie Auffret, Chloé Subecz, Manon Lancien, Yassine Ajlil, Irma Segoviano Vilchis, Kévin Beccaria, Thomas Blauwblomme, Estelle Oberlin, Jacques Grill, David Castel, Marie-Anne Debily
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
We previously identified VRK3 as a specific vulnerability in DMG-H3K27M cells in a synthetic lethality screen targeting the whole kinome. The aim of the present study was to elucidate the mechanisms by which VRK3 depletion impact DMG-H3K27M cell fitn
Externí odkaz:
https://doaj.org/article/26038bc4491a447685806cef744f67b3
Autor:
Estelle Daudigeos-Dubus, Ludivine Le Dret, Claudia Lanvers-Kaminsky, Olivia Bawa, Paule Opolon, Albane Vievard, Irène Villa, Mélanie Pagès, Jacques Bosq, Gilles Vassal, Dieter Zopf, Birgit Geoerger
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142612 (2015)
The multikinase inhibitor regorafenib (BAY 73-4506) exerts both anti-angiogenic and anti-tumorigenic activity in adult solid malignancies mainly advanced colorectal cancer and gastrointestinal stromal tumors. We intended to explore preclinically the
Externí odkaz:
https://doaj.org/article/e1cbbe697d294983a04675b1b34cb582
Autor:
Walter E. Haefeli, Alexander Muck, Ludivine Le Dret, Marius Majewsky, Stefan M. Pfister, Britta Statz, Jürgen Burhenne, Sonja Krausert, David Castel, Julia Benzel, Margaux Fresnais, Rémi Longuespée
Publikováno v:
Journal of the American Society for Mass Spectrometry. 31:742-751
Ion mobility spectrometry (IMS) represents a considerable asset for analytics of complex samples as it allows for rapid mass spectrometric separation of compounds. IMS is even more useful for the separation of isobaric compounds when classical separa
Autor:
Alexandre Plessier, Ludivine Le Dret, Stéphanie Puget, David Castel, Kevin Beccaria, Marie-Anne Debily, Jacques Grill, Pascale Varlet
Publikováno v:
Expert Opinion on Orphan Drugs. 7:11-20
Introduction: DIPG represents the biggest therapeutic challenge in pediatric oncology and in neuro-oncology. Knowledge about its biology has dramatically increased in the last 5 years, but we are s...
Autor:
Marius Majewsky, Stefan M. Pfister, Walter E. Haefeli, David T.W. Jones, David Castel, Ludivine Le Dret, Pascal Johann, Jürgen Burhenne
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 151:151-158
Metabolite reference standards are often not available, which results in a lack of MS/MS spectra for library matching. Consequently, the identification of suspected metabolites proves to be challenging. The present study aims at structurally elucidat
Autor:
Irène Villa, Albane Vievard, Paule Opolon, Estelle Daudigeos-Dubus, Ludivine Le Dret, Birgit Geoerger, Olivia Bawa, Gilles Vassal, Jacques Bosq
Publikováno v:
International Journal of Oncology. 50:203-211
MET is expressed on neuroblastoma cells and may trigger tumor growth, neoangiogenesis and metastasis. MET upregulation further represents an escape mechanism to various anticancer treatments including VEGF signaling inhibitors. We developed in vitro
Autor:
Kevin Beccaria, Cathy Philippe, Pascale Varlet, David Hardy, Marie-Anne Debily, Ludivine Le Dret, David Castel, Alexandre Plessier, Arthur Felix, Jacques Grill, Jane Merlevede
Publikováno v:
Neuro-Oncology
Diffuse Intrinsic Pontine Glioma (DIPG) and more largely Diffuse Midline Gliomas H3 K27M-mutant (DMG) harbor a unique property of infiltration. Our objective is to elucidate/describe the cellular and molecular determinants of micro-environmental modi
Autor:
Nathalene Truffaux, David Castel, Patrick Saulnier, Raphael Calmon, Ludivine Le Dret, Felipe Andreiuolo, Thomas Blauwblomme, Pascale Varlet, Marie-Anne Debily, Alan Mackay, Ludovic Lacroix, Stéphanie Puget, Christian Sainte-Rose, Kathryn R. Taylor, Mélanie Pagès, Jacques Grill, Nathalie Boddaert, Chris Jones, Cathy Philippe
Publikováno v:
Acta Neuropathologica
Diffuse intrinsic pontine glioma (DIPG) is the most severe paediatric solid tumour, with no significant therapeutic progress made in the past 50 years. Recent studies suggest that diffuse midline glioma, H3-K27M mutant, may comprise more than one bio
Autor:
Didier Desmaële, Alain Deroussent, Sylvère Durand, Ludivine Le Dret, Angelo Paci, Estelle Daudigeos-Dubus, Charles Skarbek, Adeline Maury, Hubert Chapuis, Patrick Couvreur
Publikováno v:
Journal of Chromatography B. 992:30-35
The antitumor drug, ifosfamide (IFO), requires activation by cytochrome P450 (CYP) to form the active metabolite, 4-hydroxyisfosfamide (4-OHIFO), leading to toxic by-products at high dose. In order to overcome these drawbacks, preactivated ifosfamide
Autor:
Noah E. Berlow, Lining Liu, Esther Hulleman, Lara E. Davis, Ludivine Le Dret, Lin Qi, Pamelyn Woo, Paul S. Meltzer, Anitha Ponnuswami, Tessa Johung, Xiao-Nan Li, Yujie Tang, Catherine S. Grasso, Cynthia Hawkins, Marie-Anne Debily, Yuchen Du, Jinu Abraham, Matthew N. Svalina, Mari Kogiso, Marta M. Alonso, Katherine E. Warren, Eric H. Raabe, Yulun Huang, Michelle Monje, Ranadip Pal, Hua Mao, S. Chen, Jacques Grill, Dannis G. van Vuurden, Elaine C. Huang, Maryam Fouladi, Martha Quezado, Nicholas J. Wang, Wenchao Sun, Michael J. Quist, Nathalene Truffaux, Charles Keller, Paul T. Spellman, Javad Nazarian, Marianne Hütt-Cabezas
Publikováno v:
Nature Medicine, 21(6), 555-559. Nature Publishing Group
Nature medicine
Grasso, C S, Tang, Y J, Truffaux, N, Berlow, N E, Liu, L N, Debily, M A, Quist, M J, Davis, L E, Huang, E C, Woo, P J, Ponnuswami, A, Chen, S, Johung, T B, Sun, W C, Kogiso, M, Dui, Y C, Qi, L, Huang, Y L, Hutt-Cabezas, M, Warrenm, K E, Le Dret, L, Meltzerm, P S, Mao, H, Quezado, M, van Vuurden, D G, Abraham, J, Fouladi, M, Svalina, M N, Wang, N, Hawkins, C, Nazarian, J, Alonso, M M, Raabe, E H, Hulleman, E, Spellman, P T, Li, X N, Keller, C, Pal, R, Grill, J & Monje, M 2015, ' Functionally defined therapeutic targets in diffuse intrinsic pontine glioma ', Nature Medicine, vol. 21, no. 6, pp. 555-559 . https://doi.org/10.1038/nm.3855
Nature medicine
Grasso, C S, Tang, Y J, Truffaux, N, Berlow, N E, Liu, L N, Debily, M A, Quist, M J, Davis, L E, Huang, E C, Woo, P J, Ponnuswami, A, Chen, S, Johung, T B, Sun, W C, Kogiso, M, Dui, Y C, Qi, L, Huang, Y L, Hutt-Cabezas, M, Warrenm, K E, Le Dret, L, Meltzerm, P S, Mao, H, Quezado, M, van Vuurden, D G, Abraham, J, Fouladi, M, Svalina, M N, Wang, N, Hawkins, C, Nazarian, J, Alonso, M M, Raabe, E H, Hulleman, E, Spellman, P T, Li, X N, Keller, C, Pal, R, Grill, J & Monje, M 2015, ' Functionally defined therapeutic targets in diffuse intrinsic pontine glioma ', Nature Medicine, vol. 21, no. 6, pp. 555-559 . https://doi.org/10.1038/nm.3855
Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strat