Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Ludger, Klein"'
Autor:
Kristina Zec, Stephanie Thiebes, Jenny Bottek, Devon Siemes, Philippa Spangenberg, Duc Viet Trieu, Nils Kirstein, Nirojah Subramaniam, Robin Christ, Diana Klein, Verena Jendrossek, Maria Loose, Florian Wagenlehner, Jadwiga Jablonska, Thilo Bracht, Barbara Sitek, Bettina Budeus, Ludger Klein-Hitpass, Dirk Theegarten, Olga Shevchuk, Daniel R. Engel
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionStreptococcus pneumoniae is one of the main causes of community-acquired infections in the lung alveoli in children and the elderly. Alveolar macrophages (AM) patrol alveoli in homeostasis and under infectious conditions. However, the mol
Externí odkaz:
https://doaj.org/article/23d3fe4f1c024fdb82b614f980d5c4d4
Autor:
Anne-Charlotte Antoni, Ekaterina Pylaeva, Bettina Budeus, Jadwiga Jablonska, Ludger Klein-Hitpaß, Marcel Dudda, Stefanie B. Flohé
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Sepsis is associated with profound immune dysregulation that increases the risk for life-threatening secondary infections: Dendritic cells (DCs) undergo functional reprogramming due to yet unknown changes during differentiation in the bone marrow (BM
Externí odkaz:
https://doaj.org/article/ea97a97caf654e0795a48ce4cafce52c
Autor:
Matouš Vobořil, Tomáš Brabec, Jan Dobeš, Iva Šplíchalová, Jiří Březina, Adéla Čepková, Martina Dobešová, Aigerim Aidarova, Jan Kubovčiak, Oksana Tsyklauri, Ondřej Štěpánek, Vladimír Beneš, Radislav Sedláček, Ludger Klein, Michal Kolář, Dominik Filipp
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Immune tolerance is mediated by the deletion of autoreactive T cells via medullary thymic epithelial cells (mTEC) and dendritic cells (DC), and by the induction of regulatory T cells (Treg). Here the authors show that mTEC receiving toll-like recepto
Externí odkaz:
https://doaj.org/article/17ae763d83f941499c6713566243bf8e
Autor:
Stephanie T. Jünger, Martin Mynarek, Inken Wohlers, Evelyn Dörner, Anja zur Mühlen, Natalia Velez-Char, Katja von Hoff, Stefan Rutkowski, Monika Warmuth-Metz, Rolf-Dieter Kortmann, Beate Timmermann, Sven Rahmann, Ludger Klein-Hitpass, Andre O. von Bueren, Torsten Pietsch
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Introduction Risk stratification of children with ependymomas of the posterior fossa in current therapeutic protocols is mainly based on clinical criteria. We aimed to identify independent outcome predictors for this disease entity by a syst
Externí odkaz:
https://doaj.org/article/b6f10fd32cfe498ea52b2120536a0527
Autor:
Alexa N. Lauer, Rene Scholtysik, Andreas Beineke, Christoph Georg Baums, Kristin Klose, Peter Valentin-Weigand, Hiroshi Ishikawa, Horst Schroten, Ludger Klein-Hitpass, Christian Schwerk
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Streptococcus suis (S. suis) is an important opportunistic pathogen, which can cause septicemia and meningitis in pigs and humans. Previous in vivo observations in S. suis-infected pigs revealed lesions at the choroid plexus (CP). In vitro experiment
Externí odkaz:
https://doaj.org/article/1f15b0cd66be487c981aeb7ca9990747
Autor:
Patricia Johansson, Laura Dierichs, Ludger Klein-Hitpass, Anke K. Bergmann, Michael Möllmann, Sascha Menninger, Peter Habenberger, Bert Klebl, Jens T. Siveke, Ulrich Dührsen, Axel Choidas, Jan Dürig
Publikováno v:
Therapeutic Advances in Hematology, Vol 11 (2020)
T-cell prolymphocytic leukemia (T-PLL) is an aggressive malignancy characterized by chemotherapy resistance and a median survival of less than 2 years. Here, we investigated the pharmacological effects of the novel highly specific cyclin-dependent ki
Externí odkaz:
https://doaj.org/article/dbaad95c53fa476da2bd0fedf8b2e735
Autor:
Maurizio Mangolini, Frederik Götte, Andrew Moore, Tim Ammon, Madlen Oelsner, Gloria Lutzny-Geier, Ludger Klein-Hitpass, James C. Williamson, Paul J. Lehner, Jan Dürig, Michael Möllmann, Lívia Rásó-Barnett, Katherine Hughes, Antonella Santoro, Simón Méndez-Ferrer, Robert A. J. Oostendorp, Ursula Zimber-Strobl, Christian Peschel, Daniel J. Hodson, Marc Schmidt-Supprian, Ingo Ringshausen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The Wnt pathway is one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL) and is activated in only a subset of patients; however, no universal drivers of the disease have been identified. Here the authors show that Notch2 and β
Externí odkaz:
https://doaj.org/article/c4f9c099f3104cabbf026773512a17d1
Autor:
Christopher Schröder, Elsa Leitão, Stefan Wallner, Gerd Schmitz, Ludger Klein-Hitpass, Anupam Sinha, Karl-Heinz Jöckel, Stefanie Heilmann-Heimbach, Per Hoffmann, Markus M. Nöthen, Michael Steffens, Peter Ebert, Sven Rahmann, Bernhard Horsthemke
Publikováno v:
Epigenetics & Chromatin, Vol 10, Iss 1, Pp 1-18 (2017)
Abstract Background There is increasing evidence for inter-individual methylation differences at CpG dinucleotides in the human genome, but the regional extent and function of these differences have not yet been studied in detail. For identifying reg
Externí odkaz:
https://doaj.org/article/b29c717003854f678a6bbf2253c68dc6
Autor:
Antje Sucker, Fang Zhao, Natalia Pieper, Christina Heeke, Raffaela Maltaner, Nadine Stadtler, Birgit Real, Nicola Bielefeld, Sebastian Howe, Benjamin Weide, Ralf Gutzmer, Jochen Utikal, Carmen Loquai, Helen Gogas, Ludger Klein-Hitpass, Michael Zeschnigk, Astrid M. Westendorf, Mirko Trilling, Susanne Horn, Bastian Schilling, Dirk Schadendorf, Klaus G. Griewank, Annette Paschen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
IFNγ secretion by CD8+T cells is critical for immunotherapy efficacy. In this study, the authors show that melanoma patients can become resistant to immunotherapy by acquiring chromosomal alterations and subsequent inactivating mutations in genes of
Externí odkaz:
https://doaj.org/article/7dba103f7a864f4c8cb9130aa2e816d2
Autor:
Bettina Wöchtl, Florian Gunzer, Wilhelm Gerner, Hagen Gasse, Michaela Koch, Zoltán Bagó, Martin Ganter, Herbert Weissenböck, Nora Dinhopl, Sina M. Coldewey, Alexandra von Altrock, Karl-Heinz Waldmann, Armin Saalmüller, Kurt Zimmermann, Jörg Steinmann, Jan Kehrmann, Ludger Klein-Hitpass, Jochen Blom, Ralf Ehricht, Ines Engelmann, Isabel Hennig-Pauka
Publikováno v:
Gut Pathogens, Vol 9, Iss 1, Pp 1-18 (2017)
Abstract Background Shiga toxin (Stx) producing Escherichia coli (E. coli) (STEC) is the most frequent cause of diarrhoea-positive haemolytic uraemic syndrome (D + HUS) in humans. In 2011, a huge outbreak with an STEC O104:H4 strain in Germany highli
Externí odkaz:
https://doaj.org/article/031960d9048645ac86ac1874ea9f1037