Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Ludger, Dinkelborg"'
Autor:
Francesca Capotosti, Emanuele Gabellieri, Ludger Dinkelborg, Hanno Schieferstein, Nampally Sreenivasachary, Andre Mueller, Mathias Berndt, Heiko Kroth, Andrew W. Stephens, David T. Hickman, Andreia Monica Serra, Andrea Pfeifer, Heribert Schmitt-Willich, Jérôme Molette, Felix Oden
Publikováno v:
Journal of Medicinal Chemistry. 64:12808-12830
The first candidate PI-2014 was tested in healthy controls and subjects with Alzheimer's disease (AD). As PI-2014 displayed off-target binding to monoamine oxidase A (MAO-A), a new lead with improved binding to Tau and decreased MAO-A binding was req
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2e826303fd6fd1e6ecb77723cc30be7
https://doi.org/10.1021/acs.jmedchem.1c00861
https://doi.org/10.1021/acs.jmedchem.1c00861
Autor:
Santiago Bullich, Susan De Santi, Norman Koglin, Ludger Dinkelborg, Audrey Perrotin, Kenneth Marek, John Seibyl, Mathias Berndt, Olivier Barret, Andrew W. Stephens, Andre Mueller, Andrea Pfeifer, Heiko Kroth, Gilles Tamagnan, Jennifer Madonia, Caroline Papin
Publikováno v:
Journal of Nuclear Medicine. 61:911-919
18F-PI-2620 is a PET tracer with high binding affinity for aggregated tau, a key pathologic feature of Alzheimer disease (AD) and other neurodegenerative disorders. Preclinically, 18F-PI-2620 binds to both 3-repeat and 4-repeat tau isoforms. The purp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0798f4690095f2618d4cdca4a60b0f66
https://doi.org/10.2967/jnumed.119.236224
https://doi.org/10.2967/jnumed.119.236224
Autor:
Yvan Varisco, Francesca Capotosti, Ludger Dinkelborg, Cédric Boudou, Emanuele Gabellieri, Gilles Tamagnan, David T. Hickman, Vincent Darmency, Andrew W. Stephens, Andre Mueller, Heiko Kroth, Mathias Berndt, Tanja Juergens, Jérôme Molette, Andrea Pfeifer, Heribert Schmitt-Willich, Hanno Schieferstein, Efthymia Vokali, Felix Oden, Andreas Muhs
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 46:2178-2189
Purpose Tau deposition is a key pathological feature of Alzheimer’s disease (AD) and other neurodegenerative disorders. The spreading of tau neurofibrillary tangles across defined brain regions corresponds to the observed level of cognitive decline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7c502df1f676d2e3b0868badd00cdf7
https://doi.org/10.1007/s00259-019-04397-2
https://doi.org/10.1007/s00259-019-04397-2
Autor:
Henryk Barthel, Santiago Bullich, Ludger Dinkelborg, Vincent Dore, Christopher C. Rowe, Andrew W. Stephens, Victor L. Villemagne, Colin L. Masters, Olivier Salvado, Jurgen Fripp, Susan De Santi, Pierrick Bourgeat, Salamata Konate, Osama Sabri
Publikováno v:
Alzheimer's & Dementia. 15:807-816
Introduction 18F-florbetaben is currently approved for the visual rule out of β-amyloid (Aβ) pathology. It is also used for recruitment and as an outcome measure in therapeutic trials, requiring accurate and reproducible quantification of Aβ burde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de0b3bf0ccb2f5ebfc72ec3519d91d52
https://doi.org/10.1016/j.jalz.2019.02.005
https://doi.org/10.1016/j.jalz.2019.02.005
Autor:
Mathias Berndt, Jennifer Madonia, Heiko Kroth, Andrea Pfeifer, Andre Mueller, Kenneth Marek, Susan De Santi, Andrew W. Stephens, Christine M. Sandiego, Caroline Papin, Gilles Tamagnan, Ludger Dinkelborg, Cristian Constantinescu, Audrey Perrotin, John Seibyl, Olivier Barret, Norman Koglin, Santiago Bullich
Publikováno v:
J Nucl Med
18F-PI-2620 is a next generation tau positron emission tomography (PET)-tracer that has demonstrated ability to image the spatial distribution of suspected tau pathology. The objective of this study was to assess the tracer biodistribution, dosimetry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce72eb273cbebbc6f2eff58a3d823db9
https://europepmc.org/articles/PMC7262221/
https://europepmc.org/articles/PMC7262221/
Autor:
Ludger Dinkelborg, Hanno Schieferstein, Tanja Juergens, Andrew W. Stephens, Nampally Sreenivasachary, Felix Oden, Mathias Berndt, Emanuele Gabellieri, Andre Mueller, Heiko Kroth, Jérôme Molette, Yvan Varisco, Andrea Pfeifer, David T. Hickman, Francesca Capotosti, Heribert Schmitt-Willich
Publikováno v:
European journal of medicinal chemistry. 204
The compound screening was initiated with a direct staining assay to identify compounds binding to Tau aggregates and not Abeta plaques using human brain sections derived from late stage Alzheimer's disease donors. The binding of Tau aggregate select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eae20009bd62126268dd92bca1c77a3
https://pubmed.ncbi.nlm.nih.gov/32771872
https://pubmed.ncbi.nlm.nih.gov/32771872
Autor:
Gayatri Gowrishankar, Sabine Zitzmann-Kolbe, Anitha Junutula, Robert Reeves, Jelena Levi, Ananth Srinivasan, Kjerstin Bruus-Jensen, John Cyr, Ludger Dinkelborg, Sanjiv S Gambhir
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26902 (2011)
F18 2-Fluoro 2-deoxyglucose (FDG) has been the gold standard in positron emission tomography (PET) oncologic imaging since its introduction into the clinics several years ago. Seeking to complement FDG in the diagnosis of breast cancer using radio la
Externí odkaz:
https://doaj.org/article/12fa90f743f548de82cd2b73c5d72bc2
Autor:
Gareth Jones, Andrew W. Stephens, Victor L. Villemagne, Susan De Santi, Colin L. Masters, Vincent Dore, Rachel S. Mulligan, David Baxendale, Santiago Bullich, Ludger Dinkelborg, Christopher C. Rowe
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging
The Centiloid (CL) method enables quantitative values from Aβ-amyloid (Aβ) imaging to be expressed in a universal unit providing pathological, diagnostic and prognostic thresholds in clinical practice and research and allowing integration of multip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5794f4a6c4744819c2bef537adc9b24
https://doi.org/10.1007/s00259-017-3749-6
https://doi.org/10.1007/s00259-017-3749-6
Autor:
Jessica Lohrke, Andre Mueller, Ludger Dinkelborg, Markus Berger, Holger Siebeneicher, Marcus Bauser, Joachim Huetter, Matthias Friebe, Michael Reinhardt, Felix Oden, Norman Koglin, Marion Zerna, Mathias Berndt, Andrew W. Stephens
Publikováno v:
Journal of Nuclear Medicine. 58:1094-1099
Thromboembolic diseases such as myocardial infarction, stroke, transient ischemic attacks and pulmonary embolism are major causes of morbidity and mortality worldwide. GPIIb/IIIa is the key receptor involved in platelet aggregation and is a validated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf3ce5ee463b53c531098e63eb264aed
https://doi.org/10.2967/jnumed.116.188896
https://doi.org/10.2967/jnumed.116.188896
Autor:
Heiko, Kroth, Felix, Oden, Jerome, Molette, Hanno, Schieferstein, Francesca, Capotosti, Andre, Mueller, Mathias, Berndt, Heribert, Schmitt-Willich, Vincent, Darmency, Emanuele, Gabellieri, Cédric, Boudou, Tanja, Juergens, Yvan, Varisco, Efthymia, Vokali, David T, Hickman, Gilles, Tamagnan, Andrea, Pfeifer, Ludger, Dinkelborg, Andreas, Muhs, Andrew, Stephens
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging
Purpose Tau deposition is a key pathological feature of Alzheimer’s disease (AD) and other neurodegenerative disorders. The spreading of tau neurofibrillary tangles across defined brain regions corresponds to the observed level of cognitive decline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e37d71c63a7bb9e0f5c438e1b89bedf
https://pubmed.ncbi.nlm.nih.gov/31264169
https://pubmed.ncbi.nlm.nih.gov/31264169