Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ludek Sispera"'
Autor:
Stanislav Mičuda, Martin Hodač, Petr Pařízek, Miloslav Pleskot, Luděk Šišpera, Jaroslav Cerman, Jana Maláková, Jiřina Martínková, Vladimír Pidrman
Publikováno v:
Acta Medica, Vol 43, Iss 3, Pp 95-101 (2000)
The present work was designed to determine whether the individual differences in pharmacokinetics and pharmacodynamics of amiodarone and its N-desethyl metabolite are related to cytochrome CYP3A metabolizer status. Methods: 12 cardiac patients with i
Externí odkaz:
https://doaj.org/article/eb60fc5d97cb471782cf9d559d64cee9
Autor:
Milos Hroch, Martina Rezacova, Ales Bezrouk, Jana Cmielova, Renata Köhlerová, Ludek Sispera, Radim Havelek, Emil Rudolf, Lenka Sucha, Pavel Tomsik
Publikováno v:
Oncology Reports
In recent years, α-tomatine has been studied for its anticancer activity. In the present study, we focused on the cytotoxic effect of α-tomatine in the MCF-7 human breast adenocarcinoma cell line, its mechanism of action, biotransformation and stab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56623efd9b0fae91ddb97cda3a2cab57
http://europepmc.org/articles/PMC3839989
http://europepmc.org/articles/PMC3839989
Autor:
Milan Holecek, Ludek Sispera
Publikováno v:
Nutrients
Nutrients, Vol 8, Iss 4, p 206 (2016)
Nutrients, Vol 8, Iss 4, p 206 (2016)
Chronic arginine intake is believed to have favorable effects on the body. However, it might be hypothesized that excessive consumption of an individual amino acid exerts adverse effects on distribution and metabolism of other amino acids. We evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4e252d2380286696316aa0593f699f2b
http://europepmc.org/articles/PMC4848675
http://europepmc.org/articles/PMC4848675
Autor:
Jolana Cermanova, Pavel Tomsik, Halka Lotková, Ludek Sispera, Martina Slanarova, Radek Hyspler, Stanislav Micuda, Eva Brcakova, Leos Fuksa, Gabriela Kolouchova, Petra Hirsova
Publikováno v:
Journal of Gastroenterology and Hepatology. 26:1544-1551
Background and Aim: The administration of pravastatin to patients with cholestatic liver disease has suggested the potential of the drug with regard to reducing raised plasma cholesterol and bile acid levels. Information about the mechanisms associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a82d30580f9a1f65c59883c796842196
https://doi.org/10.1111/j.1440-1746.2011.06748.x
https://doi.org/10.1111/j.1440-1746.2011.06748.x
Publikováno v:
Journal of Physiology and Biochemistry. 66:311-319
β-Hydroxy-β-methylbutyrate (HMB) is a leucine metabolite that may have a positive effect in protein catabolic conditions. Therefore, we hypothesized that HMB treatment could attenuate the sepsis-induced protein catabolic state. The aims of our stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655aa7be65ad5f334e323c3f2d36afe4
https://doi.org/10.1007/s13105-010-0037-3
https://doi.org/10.1007/s13105-010-0037-3
Publikováno v:
Amino Acids. 40:575-584
Hyperammonemia is considered to be the main cause of decreased levels of the branched-chain amino acids (BCAA), valine, leucine, and isoleucine, in liver cirrhosis. In this study we investigated whether the decrease in BCAA is caused by the direct ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df93f1664231372c596270ba87cb32f5
https://doi.org/10.1007/s00726-010-0679-z
https://doi.org/10.1007/s00726-010-0679-z
Autor:
Tilser I, Miroslav Kovarik, Ludek Sispera, Milan Holecek, Oleg V. Larionov, A. De Meijere, Tomas Muthny
Publikováno v:
ResearcherID
The proteasome inhibitors are used as research tools to study of the ATP-dependent ubiquitin-proteasome system. Some of them are at present undergoing clinical trials to be used as therapeutic agents for cancer or inflammation. These diseases are oft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d809e015b45f451fe87f253d29539440
https://doi.org/10.1007/bf03179064
https://doi.org/10.1007/bf03179064
Publikováno v:
Food and Chemical Toxicology. 47:255-259
Beta-hydroxy-beta-methylbutyrate (HMB) is a leucine metabolite with protein anabolic effect. The aim of the study was to examine the role of exogenous HMB on leucine and protein metabolism in whole body and selected tissues. Rats were administered by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf39f2eb48c01dfdbf481b54a95ef5f7
https://doi.org/10.1016/j.fct.2008.11.021
https://doi.org/10.1016/j.fct.2008.11.021
Publikováno v:
International Journal of Experimental Pathology. 89:64-71
The aim of our study was to evaluate the differences in protein and amino acid metabolism after subcutaneous turpentine administration in the soleus muscle (SOL), predominantly composed of red fibres, and the extensor digitorum longus muscle (EDL) co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61e1390a964110d9a36a040c635285bd
https://doi.org/10.1111/j.1365-2613.2007.00553.x
https://doi.org/10.1111/j.1365-2613.2007.00553.x
Publikováno v:
Journal of Parenteral and Enteral Nutrition. 30:467-473
Glutamine and branched-chain amino acids (BCAA; valine, leucine, and isoleucine) are used as nutrition supplements in the treatment of proteocatabolic illness. We hypothesized that simultaneous administration of BCAA and glutamine affects protein met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcdbca54254c097482bd12aee638d48
https://doi.org/10.1177/0148607106030006467
https://doi.org/10.1177/0148607106030006467