Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Ludden CT"'
Autor:
Cragoe Edward J, Gerald E. Stokker, Charles S. Sweet, H. F. Russo, L. S. Watson, Smith Robert L, Ludden Ct, Everett M. Schultz
Publikováno v:
Journal of Medicinal Chemistry. 26:585-590
The synthesis of a number of 3,4-dihydrospiro-2H-1,3-benzoxazines and their corresponding benzoxazinium salts are reported. The saluretic effects displayed by these N,O-spiroannulated 2-(aminomethyl)phenols appear to be, in part, inversely related to
Autor:
H. F. Russo, Ludden Ct, L. S. Watson, Smith Robert L, Charles S. Sweet, Gerald E. Stokker, Cragoe Edward J
Publikováno v:
Journal of Medicinal Chemistry. 24:115-117
The synthesis and biological evaluation of 4-(aminomethyl)-6-(1,1-dimethylethyl)-2-iodo-3-pyridinol dihydrochloride (7b) are described. Compound 7b proved to be highly active as a saluretic diuretic in both rats and dogs.
Autor:
Ralph Hirschmann, R. Hall, Charles S. Sweet, Gerald S. Ponticello, N. N. Share, A. Scriabine, John J. Baldwin, G. F. Lundell, Edward L. Engelhardt, Ludden Ct
Publikováno v:
Chemischer Informationsdienst. 10
Autor:
W. C. Randall, Mark B. Freedman, A. Rosegay, Ralph Hirschmann, A. W. Raab, Edward L. Engelhardt, R. D. Hartman, A. Scriabine, Ludden Ct, Walfred S. Saari, S. W. King
Publikováno v:
Journal of medicinal chemistry. 21(8)
A variety of esters of methyldopa was synthesized with the objective of obtaining derivatives that would be more efficiently absorbed from the gastrointestinal tract than the free amino acid and would undergo conversion to methyldopa readily in the b
Autor:
Smith Robert L, H. F. Russo, Everett M. Schultz, Ludden Ct, Charles S. Sweet, L. S. Watson, Gerald E. Stokker, E. J. Jun. Cragoe
Publikováno v:
Chemischer Informationsdienst. 14
Autor:
Cragoe Edward J, A. A. Deana, Gerald E. Stokker, Ludden Ct, H. F. Russo, L. S. Watson, S J deSolms, A. Scriabine, J. E. Baer, Smith Robert L, Charles S. Sweet, Everett M. Schultz
Publikováno v:
Journal of medicinal chemistry. 23(12)
A series of 2-(aminomethyl)phenols was synthesized and tested in rats and dogs for saluretic and diuretic activity. A number of these compounds exhibit a high order of activity on iv or po administration. The most active compounds belong to a subseri
Autor:
Ralph Hirschmann, R. Hall, George F. Lundell, Charles S. Sweet, Gerald S. Ponticello, John J. Baldwin, Edward L. Engelhardt, Ludden Ct, A. Scriabine, N. N. Share
Publikováno v:
Journal of medicinal chemistry. 22(6)
Modification of the pharmacological profile of the vasodilating/beta-adrenergic blocking agent 2-[4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-4-(trifluoromethyl)imidazole (1) has been investigated. Introduction of selected substitutents onto the
Autor:
Charles S. Sweet, L. S. Watson, Ludden Ct, H. F. Russo, E. J. Jun. Cragoe, Smith Robert L, Gerald E. Stokker
Publikováno v:
Chemischer Informationsdienst. 12
Autor:
L. S. Watson, E. J. Jun. Cragoe, Smith Robert L, Charles S. Sweet, H. F. Russo, Everett M. Schultz, J. E. Baer, A. Scriabine, A. A. Deana, Gerald E. Stokker, Ludden Ct, S. J. Desolms
Publikováno v:
Chemischer Informationsdienst. 12
Autor:
Walfred S. Saari, Edward L. Engelhardt, Zell Hc, Stone Ca, Marcia E. Christy, Ludden Ct, John M. Stavorski, Colton Cd, Wenger Hc
Publikováno v:
Journal of medicinal chemistry. 8(6)