Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Luda Diatchenko"'
Autor:
Nathaniel P. Hernandez, Ashleigh Rawls, Jiegen Chen, Xin Zhang, Yaomin Wang, Xianglong Gao, Marc Parisien, Mohamad Karaky, Carolina Beraldo Meloto, Francesca Montagna, Hong Dang, Yue Pan, Ying Zhao, Samuel McLean, Sarah Linnstaedt, Luda Diatchenko, Andrea G. Nackley
Publikováno v:
PAIN Reports, Vol 9, Iss 6, p e1199 (2024)
Abstract. Introduction:. Chronic primary pain conditions (CPPCs) are linked to catecholamine activation of peripheral adrenergic receptors. Yet, catecholamine-dependent epigenetic mechanisms, such as microRNA (miRNA) regulation of mRNA transcripts, r
Externí odkaz:
https://doaj.org/article/231aa958ef124f9eb03965e149bbb55c
Autor:
Adriana Angarita-Fonseca, Mathieu Roy, Anaïs Lacasse, Guillaume Léonard, Pierre Rainville, Marie-France Marin, Iulia Tufa, Erika L. Gentile, M. Gabrielle Pagé, Jean-Sébastien Roy, Hugo-Massé Alarie, Carolina B. Meloto, Erika Lauren Gentile, Erwan Leclair, Francesca Montagna, Julien Goulet, Laura S. Stone, Laurent Dupuis, Luda Diatchenko, Manon Choinière, Rubens da Silva, Martin Descarreaux, Maryse Fortin, Pierre Langevin, Mark Ware, Pascal Tétreault, Richard Hovey, Simon Deslauriers, Stephanie Grégoire, Timothy Wideman
Publikováno v:
PAIN Reports, Vol 9, Iss 4, p e1165 (2024)
Abstract. Introduction: We explored trajectories of pain intensity and depressive symptoms over the first 24 months of the pandemic in people with low back pain. Methods: This longitudinal study was conducted alongside the Quebec Low Back Pain Study.
Externí odkaz:
https://doaj.org/article/8ffb2dd4c8d043788019837500d08fc8
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/fea0c270a4484fbf902c26c68f1e6905
Autor:
Shannon Tansley, Sonali Uttam, Alba Ureña Guzmán, Moein Yaqubi, Alain Pacis, Marc Parisien, Haley Deamond, Calvin Wong, Oded Rabau, Nicole Brown, Lisbet Haglund, Jean Ouellet, Carlo Santaguida, Alfredo Ribeiro-da-Silva, Soroush Tahmasebi, Masha Prager-Khoutorsky, Jiannis Ragoussis, Ji Zhang, Michael W. Salter, Luda Diatchenko, Luke M. Healy, Jeffrey S. Mogil, Arkady Khoutorsky
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Microglia subpopulations may differentially contribute to pain. Here, the authors show that peripheral nerve injury induces time- and sex-specific transcriptional changes in mouse spinal cord microglia subpopulations and that ApoE is linked to neurop
Externí odkaz:
https://doaj.org/article/da0c9468505d43fa969f7922829123de
Publikováno v:
Stats, Vol 5, Iss 1, Pp 203-214 (2022)
Traditional case–control genetic association studies examine relationships between case–control status and one or more covariates. It is becoming increasingly common to study secondary phenotypes and their association with the original covariates
Externí odkaz:
https://doaj.org/article/cc553e84f6a245d095ee11f9d67c6ef6
Autor:
Andrey V. Bortsov, Marc Parisien, Samar Khoury, Amy E. Martinsen, Marie Udnesseter Lie, Ingrid Heuch, Kristian Hveem, John-Anker Zwart, Bendik S. Winsvold, Luda Diatchenko
Publikováno v:
PAIN Reports, Vol 7, Iss 5, p e1018 (2022)
Abstract. Introduction:. Back pain is the leading cause of disability worldwide. Although most back pain cases are acute, 20% of acute pain patients experience chronic back pain symptoms. It is unclear whether acute pain and chronic pain have similar
Externí odkaz:
https://doaj.org/article/7b12ab0c3da2446fa57ab4fb3968480c
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104390- (2022)
Summary: Large biobank repositories of clinical conditions and medications data open opportunities to investigate the phenotypic disease network. We present a graph embedded topic model (GETM). We integrate existing biomedical knowledge graph informa
Externí odkaz:
https://doaj.org/article/2bf455a4a1e44d259534d7701752f02f
Autor:
Jussi Kupari, Dmitry Usoskin, Marc Parisien, Daohua Lou, Yizhou Hu, Michael Fatt, Peter Lönnerberg, Mats Spångberg, Bengt Eriksson, Nikolaos Barkas, Peter V. Kharchenko, Karin Loré, Samar Khoury, Luda Diatchenko, Patrik Ernfors
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The contribution of distinct types of dorsal root ganglion neurons to chronic pain is unclear. Here, the authors molecularly profile non-human primate sensory neurons and show that genome-wide associations converge on two neuronal types with differen
Externí odkaz:
https://doaj.org/article/df3a304dbc84446cb7fbb921b8b45840
Autor:
Arjun Muralidharan, Susana G. Sotocinal, Noosha Yousefpour, Nur Akkurt, Lucas V. Lima, Shannon Tansley, Marc Parisien, Chengyang Wang, Jean-Sebastien Austin, Boram Ham, Gabrielle M.G.S. Dutra, Philippe Rousseau, Sioui Maldonado-Bouchard, Teleri Clark, Sarah F. Rosen, Mariam R. Majeed, Olivia Silva, Rachel Nejade, Xinyu Li, Stephania Donayre Pimentel, Christopher S. Nielsen, G. Gregory Neely, Chantal Autexier, Luda Diatchenko, Alfredo Ribeiro-da-Silva, Jeffrey S. Mogil
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)
Mice with experimental nerve damage can display long‑lasting neuropathic pain behavior. We show here that 4 months and later after nerve injury, male but not female mice displayed telomere length (TL) reduction and p53‑mediated cellular senescenc
Externí odkaz:
https://doaj.org/article/2360ec59506d468494cb5246d1be651d
Autor:
Carolina B. Meloto, Pablo Ingelmo, Eduardo Vega Perez, Rebecca Pitt, Víctor Hugo González Cárdenas, Nada Mohamed, Susana G. Sotocinal, Valerie Bourassa, Lucas Vasconcelos Lima, Alfredo Ribeiro-da-Silva, Jeffrey S. Mogil, Luda Diatchenko
Publikováno v:
PAIN Reports, Vol 6, Iss 2, p e902 (2021)
Abstract. Introduction:. Mast cell (MC) activation could establish a positive feedback loop that perpetuates inflammation and maintains pain. Stabilizing MCs with ketotifen fumarate (KF) may disrupt this loop and relieve pain. Objective:. We aimed to
Externí odkaz:
https://doaj.org/article/edb5ce97c3bc46509848427c225c9079