Spatial localisation of Discoidin Domain Receptor 2 (DDR2) signalling is dependent on its collagen binding and kinase activity.

Autor: Luczynski MT; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom., Harrison PT; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom., Lima N; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom., Krasny L; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom., Paul A; Proteomics Core Facility, The Institute of Cancer Research, London, United Kingdom., Huang PH; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom. Electronic address: paul.huang@icr.ac.uk.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2018 Jun 18; Vol. 501 (1), pp. 124-130. Date of Electronic Publication: 2018 May 03.

Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors.

Autor: Wong JP; Division of Cancer Biology, The Institute of Cancer Research, London SW3 6JB, UK., Todd JR; Division of Cancer Biology, The Institute of Cancer Research, London SW3 6JB, UK., Finetti MA; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE1 4LP, UK., McCarthy F; Division of Cancer Biology, The Institute of Cancer Research, London SW3 6JB, UK., Broncel M; Division of Cancer Biology, The Institute of Cancer Research, London SW3 6JB, UK., Vyse S; Division of Cancer Biology, The Institute of Cancer Research, London SW3 6JB, UK., Luczynski MT; Division of Cancer Biology, The Institute of Cancer Research, London SW3 6JB, UK., Crosier S; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE1 4LP, UK., Ryall KA; Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Holmes K; Division of Cancer Biology, The Institute of Cancer Research, London SW3 6JB, UK., Payne LS; Division of Cancer Biology, The Institute of Cancer Research, London SW3 6JB, UK., Daley F; The Breast Cancer Now Toby Robins Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London SW3 6JB, UK., Wai P; The Breast Cancer Now Toby Robins Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London SW3 6JB, UK., Jenks A; Division of Cancer Therapeutics, The Institute of Cancer Research, London SW3 6JB, UK., Tanos B; Division of Cancer Therapeutics, The Institute of Cancer Research, London SW3 6JB, UK., Tan AC; Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Natrajan RC; The Breast Cancer Now Toby Robins Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London SW3 6JB, UK., Williamson D; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE1 4LP, UK., Huang PH; Division of Cancer Biology, The Institute of Cancer Research, London SW3 6JB, UK. Electronic address: paul.huang@icr.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2016 Oct 25; Vol. 17 (5), pp. 1265-1275.

Direct involvement of retinoblastoma family proteins in DNA repair by non-homologous end-joining.

Autor: Cook R; Division of Cancer Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; Cancer Cell Signalling, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK., Zoumpoulidou G; Cancer Cell Signalling, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK., Luczynski MT; Division of Cancer Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK., Rieger S; Cancer Cell Signalling, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK., Moquet J; Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot OX11 0RQ, UK., Spanswick VJ; Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK., Hartley JA; Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK., Rothkamm K; Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot OX11 0RQ, UK., Huang PH; Division of Cancer Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK. Electronic address: paul.huang@icr.ac.uk., Mittnacht S; Division of Cancer Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; Cancer Cell Signalling, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK. Electronic address: s.mittnacht@ucl.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2015 Mar 31; Vol. 10 (12), pp. 2006-18. Date of Electronic Publication: 2015 Mar 26.

Discoidin domain receptors: a proteomic portrait.

Autor: Iwai LK; Protein Networks Team, Division of Cancer Biology, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK., Luczynski MT, Huang PH

Publikováno v: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2014 Sep; Vol. 71 (17), pp. 3269-79. Date of Electronic Publication: 2014 Apr 05.

Therapeutic advances of targeting receptor tyrosine kinases in cancer.

Autor: Tomuleasa, Ciprian, Tigu, Adrian-Bogdan, Munteanu, Raluca, Moldovan, Cristian-Silviu, Kegyes, David, Onaciu, Anca, Gulei, Diana, Ghiaur, Gabriel, Einsele, Hermann, Croce, Carlo M.

Publikováno v: Signal Transduction & Targeted Therapy; 8/14/2024, Vol. 9 Issue 1, p1-51, 51p