Výsledky vyhledávání

A review of the primary nutritional and environmental factors associated with Parkinson’s disease

Autor: Mitra J. Z. Hartmann, Lucy Yin, Eleanor Considine

Publikováno v: Journal of Student Research. 10

Parkinson’s disease is a progressive nervous system disorder that produces both motor and nonmotor symptoms. This literature review begins by examining evidence for several possible origins for the disease: does it begin in the brain and progress t

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https://doi.org/10.47611/jsrhs.v10i2.1482

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Rapid Earthquake Discrimination for Earthquake Early Warning: A Bayesian Probabilistic Approach Using Three‐Component Single‐Station Waveforms and Seismicity Forecast

Autor: Thomas H. Heaton, Lucy Yin, Jennifer E. Andrews

Publikováno v: Bulletin of the Seismological Society of America. 108:2054-2067

The utility of Earthquake Early Warning (EEW) relies on the robust and rapid classification of near‐site earthquake source signals from noise and teleseismic arrivals. To achieve this goal, we propose using the three‐component acceleration and ve

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https://doi.org/10.1785/0120170138

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Reducing process delays for real-time earthquake parameter estimation – An application of KD tree to large databases for Earthquake Early Warning

Autor: Jennifer E. Andrews, Thomas H. Heaton, Lucy Yin

Publikováno v: Computers & Geosciences. 114:22-29

Earthquake parameter estimations using nearest neighbor searching among a large database of observations can lead to reliable prediction results. However, in the real-time application of Earthquake Early Warning (EEW) systems, the accurate prediction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f241d001fd407bbab144bd7638dd9143
https://doi.org/10.1016/j.cageo.2018.01.001

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Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways

Autor: Zhiping Zhang, Alan Payne, Maria Mirotsou, Victor J. Dzau, Richard E. Pratt, Jeffrey Schmeckpeper, Amanda Verma, Farideh Beigi, Lucy Yin, Lunan Zhang

Publikováno v: Journal of Molecular and Cellular Cardiology. 85:215-225

Wnt signaling has recently emerged as an important regulator of cardiac progenitor cell proliferation and differentiation, but the exact mechanisms by which Wnt signaling modulates these effects are not known. Understanding these mechanisms is essent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebd844793a81c2553dc4fd483420ad6
https://doi.org/10.1016/j.yjmcc.2015.06.003

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Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression

Autor: Jiaying Lin, Shiliang Chen, She-Juan An, Jin-Ji Yang, Xu-Chao Zhang, Zhi Zhou Xie, Xiaolin Zhang, Qing Zhou, Yi-Long Wu, Shirley Zhang, Xue-Ning Yang, Mike Zhu, Lucy Yin

Publikováno v: Molecular Cancer
Molecular Cancer, Vol 9, Iss 1, p 188 (2010)

Background The anaplastic lymphoma kinase (ALK) gene is frequently involved in translocations that lead to gene fusions in a variety of human malignancies, including lymphoma and lung cancer. Fusion partners of ALK include NPM, EML4, TPM3, ATIC, TFG,

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https://pubmed.ncbi.nlm.nih.gov/20624322

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AZD3759, an EGFR inhibitor with blood brain barrier (BBB) penetration for the treatment of non-small cell lung cancer (NSCLC) with brain metastasis (BM): Preclinical evidence and clinical cases

Autor: Kan Chen, Ziqiang Cheng, Myung-Ju Ahn, Zhenfan Yang, Paul D. Martin, Dong Wan Kim, Lucy Yin, Haiyi Jiang, James Chih-Hsin Yang

Publikováno v: Journal of Clinical Oncology. 33:8016-8016

8016 Background: Increasing numbers of EGFRm+ NSCLC patients with BM have been reported, while effective treatment is lacking due to limited BBB penetration of currently available EGFR TKIs. Here w...

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https://doi.org/10.1200/jco.2015.33.15_suppl.8016

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The role of epidermal growth factor receptor mutations (EGFRm) in NSCLC with leptomeningeal metastasis: A prospective observational study

Autor: Yan Xu, Xiaoyan Si, Wei Zhong, Yi Xiao, Yu Bai, Minjiang Chen, Longyun Li, Xin Ye, Mengzhao Wang, Xiaotong Zhang, Lucy Yin, Jing Zhao, Hanping Wang, Zhenfan Yang, Jessie Xu, Li Zhang

Publikováno v: Journal of Clinical Oncology. 33:e19070-e19070

e19070 Background: Leptomeningeal metastasis (LM) is one of the disastrous events when managing advanced NSCLC due to a grave prognosis with median survival less than 12 weeks. However, little is k...

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https://doi.org/10.1200/jco.2015.33.15_suppl.e19070

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Abstract 5186: PPME1 is a potential novel molecular target in gastric and lung cancer

Autor: Guanshan Zhu, Shuqiong Fan, Zeren Gao, Jiangang Fu, Jingchuan Zhang, Jing Li, Qunsheng Ji, Xinying Su, De-Hua Yu, Ziliang Qian, Charles Liu, Sufang Han, Lucy Yin

Publikováno v: Cancer Research. 73:5186-5186

Protein phosphatase 2A (PP2A) is a human tumor suppressor, and it accounts for the majority of serine/threonine phosphatase activity which is tightly regulated via the methylation of carboxy-terminal of PP2A. Methylation at the carboxyterminal Leu 30

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https://doi.org/10.1158/1538-7445.am2013-5186

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Abstract 904: The TNIK kinase is a potential target in non-small cell lung and gastric cancer

Autor: Derek Dehua Yu, Xiuhua Zhang, Christina Wang, Eva Hu, Harvey Dong, Mike Zhu, Ziliang Qian, Zeren Gao, Joan Fan, Xinying Su, Jessie Xu, Li Zheng, Lucy Yin, Qunsheng Ji

Publikováno v: Cancer Research. 72:904-904

Traf2- and Nck-interacting kinase (TNIK) is one of germinal centre kinase (GCK) family members involved in cytoskeleton organization and neuronal dendrite extension. Emerging evidence indicated that TNIK is essential in activation of WNT pathway and

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https://doi.org/10.1158/1538-7445.am2012-904

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Abstract 1643: AZD4547, a potent and selective inhibitor of FGF-receptor tyrosine kinases 1, 2 and 3, inhibits the growth of FGF-receptor 2 driven gastric cancer models in vitro and in vivo

Autor: Maggie Wang, Liang Xie, Jessie Xu, Xinying Su, David Zhang, Lily Tang, Zengquan Wang, Jingchuan Zhang, Qunsheng Ji, Lucy Yin, Katherine Ye, Elaine Kilgour

Publikováno v: Cancer Research. 71:1643-1643

Gastric cancer is the second most lethal cancer worldwide. We and others have shown that the FGFR2 gene is amplified in a subset of gastric cancers. To validate FGFR2 as a potential therapeutic target for gastric cancer, we employed an inducible shRN

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https://doi.org/10.1158/1538-7445.am2011-1643

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