Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lucy W. King"'
Autor:
Jeffery Alan Zablocki, Neal F. Haas, Anita K. Salyers, S.G. Panzer-Knodle, Beatrice B. Taite, Larry P. Feigen, Marc Herin, Kay Broschat, Lucy W. King, Phillipe Jacqmin, Bradley T. Keller, V. Wayne Engleman, Nancy S. Nicholson, James A. Szalony
Publikováno v:
Circulation. 91:403-410
Background Intravenous therapy has been shown to be beneficial in the prevention of acute platelet-associated thrombotic events. However, orally active agents would be advantageous for chronic therapy. Fibrinogen receptor antagonists block the fibrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336714372463ad6d39ffad92b62638ee
https://doi.org/10.1161/01.cir.91.2.403
https://doi.org/10.1161/01.cir.91.2.403
Autor:
Larry P. Feigen, Leo G. Frederick, James A. Szalony, Lucy W. King, Nancy S. Nicholson, Anita K. Salyers, Osman D. Suleymanov, Beatrice B. Taite
Publikováno v:
Circulation. 98(8)
Background —Inhibition of platelet aggregation by preventing the binding of fibrinogen to glycoprotein (GP) IIb/IIIa on activated platelets results in antithrombotic activity. We report on the antithrombotic effect of xemilofiban (SC-54684A), an or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffe22c0e819358242abf0fefbc14bf7
https://pubmed.ncbi.nlm.nih.gov/9727553
https://pubmed.ncbi.nlm.nih.gov/9727553
Autor:
Osman D. Suleymanov, Lucy W. King, Nancy S. Nicholson, Leo G. Frederick, Anita K. Salyers, Larry P. Feigen
Publikováno v:
Circulation. 93(1)
Background Fibrinogen receptor antagonists block the fibrinogen-platelet interaction at the GPIIb/IIIa receptors and inhibit thrombus formation. SC-54701 is the active metabolite of SC-54684A, an orally active fibrinogen receptor antagonist. We compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93aa55f9a904ab01d690a25c931a86e
https://pubmed.ncbi.nlm.nih.gov/8616919
https://pubmed.ncbi.nlm.nih.gov/8616919
Autor:
Nancy S. Nicholson, J. G. Rico, Kenneth Williams, Foe S. Tjoeng, P. R. Bovy, Lucy W. King, Anita K. Salyers, Lori Ann Schretzman, Beatrice B. Taite, Robert B. Garland, Masateru Miyano, Susan G. Panzer-Knodle, Jeffery A. Zablocki, R. J. Lindmark, Mihaly V. Toth, Dudley E. McMackins, James G. Campion, Mark E. Zupec, Larry P. Feigen, Steven Paul Adams
Publikováno v:
Bioorganicmedicinal chemistry. 3(5)
A novel series of orally active fibrinogen receptor antagonists has been discovered through structural modification of our lead intravenous (iv) antiplatelet agent, 5-(4-amidinophenyl)pentanoyl-Asp-Phe 1 (SC-52012). The Asp-Phe amide bond was removed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457021deb18f6befd4e2a794535a39c6
https://pubmed.ncbi.nlm.nih.gov/7648203
https://pubmed.ncbi.nlm.nih.gov/7648203
Autor:
S.G. Panzer-Knodle, Lucy W. King, Nancy S. Nicholson, V. Wayne Engleman, F.Siong Tjoeng, Brad T. Keller, Todd D. Giorgio, Beatrice B. Taite, Larry P. Feigen
Publikováno v:
Thrombosis research. 74(5)
Fibrinogen binding is required for platelet aggregation and subsequent thrombus formation. SC-49992 (SC), an RGDF mimetic, is a potent and specific inhibitor of the binding of fibrinogen to its receptor on activated platelets, glycoprotein IIb/IIIa (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a380664a102cffa910569c2b62b7614
https://pubmed.ncbi.nlm.nih.gov/8085253
https://pubmed.ncbi.nlm.nih.gov/8085253
Autor:
F. Siong Tjoeng, Kam F. Fok, Mark E. Zupec, Robert B. Garland, Masateru Miyano, Susan Panzer-Knodle, Lucy W. King, Bea B. Taite, Nancy S. Nicholson, Larry P. Feigen, Steven P. Adams
Publikováno v:
Peptides ISBN: 9789401050050
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::132109607e2ff04a1cbbbfa48adf3a99
https://doi.org/10.1007/978-94-011-2264-1_302
https://doi.org/10.1007/978-94-011-2264-1_302
This chapter presents a comparison of the vasodepressor and vasodilator effects of prostaglandins (PGs) E 1 , E 2 , I 2 and 6–Keto–E. PGs E 1 , E 2 , and I 2 reduce blood pressure and increase blood flow in most peripheral vascular beds. These su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32f75b3c1be25599d7ae59c87557e7e4
https://doi.org/10.1016/b978-0-08-026819-4.50013-1
https://doi.org/10.1016/b978-0-08-026819-4.50013-1