Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Lucy Thorne"'
Autor:
Hataf Khan, Rebecca P Sumner, Jane Rasaiyaah, Choon Ping Tan, Maria Teresa Rodriguez-Plata, Chris Van Tulleken, Douglas Fink, Lorena Zuliani-Alvarez, Lucy Thorne, David Stirling, Richard SB Milne, Greg J Towers
Publikováno v:
eLife, Vol 9 (2020)
HIV-1 must replicate in cells that are equipped to defend themselves from infection through intracellular innate immune systems. HIV-1 evades innate immune sensing through encapsidated DNA synthesis and encodes accessory genes that antagonize specifi
Externí odkaz:
https://doaj.org/article/a655391dba6548b0b54ade4c8ae5e3b2
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
Background: Due to their role in fine-tuning cellular protein expression, microRNAs both promote viral replication and contribute to antiviral responses, for a range of viruses. The interactions between norovirus and the microRNA machinery have not y
Externí odkaz:
https://doaj.org/article/9c56c1cb17f74a05bdb81aad1178b67b
Autor:
Broc T. McCune, Wei Tang, Jia Lu, James B. Eaglesham, Lucy Thorne, Anne E. Mayer, Emily Condiff, Timothy J. Nice, Ian Goodfellow, Andrzej M. Krezel, Herbert W. Virgin
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT The Norovirus genus contains important human pathogens, but the role of host pathways in norovirus replication is largely unknown. Murine noroviruses provide the opportunity to study norovirus replication in cell culture and in small animals
Externí odkaz:
https://doaj.org/article/c14f5cf474dd4ad49e80a9614b687337
Autor:
Alessandra De Riva, Maja Wållberg, Francesca Ronchi, Richard Coulson, Andrew Sage, Lucy Thorne, Ian Goodfellow, Kathy D McCoy, Miyuki Azuma, Anne Cooke, Robert Busch
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181964 (2017)
Microbes, including viruses, influence type 1 diabetes (T1D) development, but many such influences remain undefined. Previous work on underlying immune mechanisms has focussed on cytokines and T cells. Here, we compared two nonobese diabetic (NOD) mo
Externí odkaz:
https://doaj.org/article/c98b1959c4fd46a5883ababcc51562fa
Publikováno v:
mSphere, Vol 1, Iss 5 (2016)
ABSTRACT Intrahost genetic diversity and replication error rates are intricately linked to RNA virus pathogenesis, with alterations in viral polymerase fidelity typically leading to attenuation during infections in vivo. We have previously shown that
Externí odkaz:
https://doaj.org/article/cf02464a170c47c0a50e0d12a59c6aa1
Autor:
Jake Dunning, Foday Sahr, Amanda Rojek, Fiona Gannon, Gail Carson, Baimba Idriss, Thomas Massaquoi, Regina Gandi, Sebatu Joseph, Hassan K Osman, Timothy J G Brooks, Andrew J H Simpson, Ian Goodfellow, Lucy Thorne, Armando Arias, Laura Merson, Lyndsey Castle, Rebecca Howell-Jones, Raul Pardinaz-Solis, Benjamin Hope-Gill, Mauricio Ferri, Jennifer Grove, Mark Kowalski, Kasia Stepniewska, Trudie Lang, John Whitehead, Piero Olliaro, Mohammed Samai, Peter W Horby, RAPIDE-TKM trial team
Publikováno v:
PLoS Medicine, Vol 13, Iss 4, p e1001997 (2016)
BackgroundTKM-130803, a small interfering RNA lipid nanoparticle product, has been developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in humans has not been evaluated.Methods and findingsIn this single-arm phase 2 t
Externí odkaz:
https://doaj.org/article/5d847f2d4b774f4e93d2e3fad6719689
Publikováno v:
eLife, Vol 3 (2014)
Lethal mutagenesis has emerged as a novel potential therapeutic approach to treat viral infections. Several studies have demonstrated that increases in the high mutation rates inherent to RNA viruses lead to viral extinction in cell culture, but evid
Externí odkaz:
https://doaj.org/article/24184d6681c14e0b83ba38a9e6f8f1e7
Autor:
Matthew Whelan, Ann Kathrin Reuschl, Clare Jolly, Mahdad Noursadeghi, Lucy Thorne, Greg J. Towers, Lorena Zuliani-Alvarez, Jane Turner
Publikováno v:
The EMBO Journal
SARS‐CoV‐2 infection causes broad‐spectrum immunopathological disease, exacerbated by inflammatory co‐morbidities. A better understanding of mechanisms underpinning virus‐associated inflammation is required to develop effective therapeutics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76296721f1aff757fd7a150f7c0ef3ae
https://doi.org/10.15252/embj.2021107826
https://doi.org/10.15252/embj.2021107826
Autor:
Benjamin J. Polacco, Kuei-Ho Chen, Matthew Whelan, Natalia Jura, Adolfo García-Sastre, Margaret Soucheray, Jacqueline M. Fabius, Kevan M. Shokat, Ian Goodfellow, Alicia L. Richards, Ajda Roic, Danielle L. Swaney, Myra Hosmillo, Danish Memon, Mahdad Noursadeghi, Ann-Kathrin Reuschl, Pedro Beltrao, Kirsten Obernier, Manisha Ummadi, Greg J. Towers, Kliment A. Verba, Aminu S Jahun, Nevan J. Krogan, Lorena Zuliani-Alvarez, Adrian Pelin, Jane Turner, Bhavya Harjai, Mehdi Bouhaddou, Hannes Braberg, Jyoti Batra, Lucy Thorne, Joseph Hiatt, Clare Jolly
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Emergence of SARS-CoV-2 variants, including the globally successful B.1.1.7 lineage, suggests viral adaptations to host selective pressures resulting in more efficient transmission. Although much effort has focused on Spike adaptation for viral entry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c581a36a2f03af50c3902155bd19036
https://pubmed.ncbi.nlm.nih.gov/34942634
https://pubmed.ncbi.nlm.nih.gov/34942634
Autor:
Maaroothen Ganeshalingham, Joe Grove, Calum Forrest, Laura E. McCoy, Samuel James Dicken, Machaela Palor, Matthew B. Reeves, Greg J. Towers, Matthew J Murray, Mphatso D Kalemera, Ann-Kathrin Reuschl, Clare Jolly, Lucy Thorne, Luke Muir
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
The recent emergence of SARS-CoV-2 variants with increased transmission, pathogenesis and immune resistance has jeopardised the global response to the COVID-19 pandemic. Determining the fundamental biology of viral variants and understanding their ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5512e98f1c5e458a6ed69c8ff5abb938
https://doi.org/10.1101/2021.03.22.436468
https://doi.org/10.1101/2021.03.22.436468
