Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lucy Tang"'
Autor:
Jie Li, Lara Lash, Nettie Roozeboom, Theodore J. Garbeff, Christopher Henze, David Murakami, Nathanial Smith, Jennifer Baerny, Lawrence Hand, Marc Shaw-Lecerf, Paul Stremel, Lucy Tang
Publikováno v:
AIAA SCITECH 2022 Forum.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51abc0ae82c88b29f480b1ac33443220
https://doi.org/10.2514/6.2022-0141
https://doi.org/10.2514/6.2022-0141
Publikováno v:
AIAA AVIATION 2021 FORUM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::958094237ac190cccc0bbe910ade6ac0
https://doi.org/10.2514/6.2021-2579
https://doi.org/10.2514/6.2021-2579
Autor:
Matthew L. Brown, Jiwen Jim Liu, Michael G. Johnson, Yingcai Wang, Jay Danao, Alison L. Budelsky, Yongli Su, Tassie L. Collins, Bettina Van Lengerich, Tod Martin, Erika Rickel, H Lucy Tang, Lisa Seitz, Wang Shen, An-Rong Li, Julio C. Medina, Xuemei Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1686-1689
Our first generation CRTH2 and DP dual antagonists, represented by AMG 009, are more potent toward the CRTH2 receptor than to the DP receptor. Here we report our efforts in the discovery of CRTH2 and DP dual antagonists with more balanced potencies t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06929a3e262e7a8d0be964aa900462f
https://doi.org/10.1016/j.bmcl.2011.12.107
https://doi.org/10.1016/j.bmcl.2011.12.107
Autor:
Zice Fu, Yongli Su, Xuemei Wang, Hua Lucy Tang, Timothy J. Sullivan, Lisa Seitz, Felix Gonzalez-Lopez de Turiso, Julio C. Medina, Mark P. Grillo, Shanna Lawlis, Ying Sun, Wang Shen, M.J. Schmitt, Qiuping Ye, Sarah E. Lively, Matthew L. Brown, An-Rong Li, Yingcai Wang, Bettina Van Lengerich, Jill Wait, Sujen Lai, Jiwen Liu, Michael G. Johnson, Jay Danao, Tassie L. Collins, Qingge Xu
Publikováno v:
ACS Medicinal Chemistry Letters. 2:326-330
Prostaglandin D2 (PGD2) plays a key role in mediating allergic reactions seen in asthma, allergic rhinitis, and atopic dermatitis. PGD2 exerts its activity through two G protein-coupled receptors (GPCRs), prostanoid D receptor (DP or DP1), and chemoa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1412c5f0cb7a55fd9ce712791e8a8c0f
https://doi.org/10.1021/ml1002234
https://doi.org/10.1021/ml1002234
Publikováno v:
Science. 315:528-531
The germinal center (GC) is an important site for the generation and selection of B cells bearing high-affinity antibodies, yet GC cell migration and interaction dynamics have not been directly observed. Using two-photon microscopy of mouse lymph nod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87bad96bb5875b3ea716555df45b3b78
https://doi.org/10.1126/science.1136736
https://doi.org/10.1126/science.1136736
Autor:
Keli L. Hippen, Valerie Kouskoff, Jason G. Cyster, H. Lucy Tang, Marc K. Jenkins, Kathryn A. Pape, David Nemazee, Lina E. Tze, Timothy W. Behrens
Publikováno v:
The Journal of Experimental Medicine
The life history of isotype-switched B cells is unclear, in part, because of an inability to detect rare antigen-specific B cells at early times during the immune response. To address this issue, a small population of B cells carrying targeted antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55889db1758b1a6f86f1dd39c0c7ba1d
https://doi.org/10.1084/jem.20012065
https://doi.org/10.1084/jem.20012065
Autor:
Jason G. Cyster, H. Lucy Tang
Publikováno v:
Science. 284:819-822
Langerhans' cells migrating from contact-sensitized skin were found to up-regulate expression of macrophage-derived chemokine (MDC) during maturation into lymph node dendritic cells (DCs). Naı̈ve T cells did not migrate toward MDC, but antigen-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6546ceaddc64b10d2b647146a00e294
https://doi.org/10.1126/science.284.5415.819
https://doi.org/10.1126/science.284.5415.819
Publikováno v:
Journal of Bacteriology. 180:5580-5590
The FliM protein of Escherichia coli is required for the assembly and function of flagella. Genetic analyses and binding studies have shown that FliM interacts with several other flagellar proteins, including FliN, FliG, phosphorylated CheY, other co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f545727c85288029c37d7eccb91c7d
https://doi.org/10.1128/jb.180.21.5580-5590.1998
https://doi.org/10.1128/jb.180.21.5580-5590.1998
Autor:
Michael J. Schmitt, Xuemei Wang, Alison L. Budelsky, Julio C. Medina, Wang Shen, H Lucy Tang, Jiwen Jim Liu, Derek Marshall, Tassie L. Collins, Tod Martin, Zice Fu, Yingcai Wang, Erika Rickel
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
We have previously reported that optimization of a series of phenylacetic acid derivatives led to the discovery of CRTH2 and DP dual antagonists, such as AMG 009 and AMG 853. During the optimization process, we discovered that minor structural modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5c35e3cc5a5a4823987e85abc53a25
https://pubmed.ncbi.nlm.nih.gov/22119474
https://pubmed.ncbi.nlm.nih.gov/22119474
Multiple CRTH2 antagonists are currently evaluated in human clinical trials for asthma and chronic obstructive pulmonary disease (COPD). During our lead optimization for CRTH2 antagonists, an observation of an intramolecular hydrogen bond in ortho-ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095486794c21545f4b7c5d1d45f52772
https://europepmc.org/articles/PMC4018144/
https://europepmc.org/articles/PMC4018144/
