Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Lucy Stols"'
Autor:
Karolina Michalska, Youngchang Kim, Robert Jedrzejczak, Natalia I. Maltseva, Lucy Stols, Michael Endres, Andrzej Joachimiak
Publikováno v:
IUCrJ, Vol 7, Iss 5, Pp 814-824 (2020)
Among 15 nonstructural proteins (Nsps), the newly emerging Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) encodes a large, multidomain Nsp3. One of its units is the ADP-ribose phosphatase domain (ADRP; also known as the macrodomain, Mac
Externí odkaz:
https://doaj.org/article/cb035836f3254f6cb1990635237e5aeb
Autor:
Daniel W. Kneller, Gwyndalyn Phillips, Hugh M. O’Neill, Robert Jedrzejczak, Lucy Stols, Paul Langan, Andrzej Joachimiak, Leighton Coates, Andrey Kovalevsky
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
The SARS-CoV-2 3CL main protease (3CL Mpro) is a chymotrypsin-like protease that facilitates the production of non-structural proteins, which are essential for viral replication and is therefore of great interest as a drug target. Here, the authors p
Externí odkaz:
https://doaj.org/article/b4c49bbea9c247e4bb006a3c2edf71ae
Autor:
Matthias Endres, Lucy Stols, Youngchang Kim, Natalia Maltseva, Karolina Michalska, Andrzej Joachimiak, Robert Jedrzejczak
Publikováno v:
IUCrJ, Vol 7, Iss 5, Pp 814-824 (2020)
IUCrJ
IUCrJ
High-resolution crystal structures of the ADP-ribose phosphatase domain (ADRP; also known as the macrodomain) from SARS-CoV-2 with multiple ligands illustrate how the protein undergoes conformational changes to adapt to the ligand in the manner obser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f8a9f564e691d5a8ba0741aa0053d3
https://doi.org/10.1107/s2052252520009653
https://doi.org/10.1107/s2052252520009653
Autor:
Krzysztof Fidelis, Youngchang Kim, Leila Tamara Alexander, A. Joachimiak, John A. Tainer, Athanassios Adamopoulos, William Sam Nutt, Rhys Grinter, Andrei N. Lupas, Bettina Böttcher, Yannick J. Bomble, Andriy Kryshtafovych, Tatjana Heidebrecht, Wah Chiu, Cécile Breyton, Stefan L. Oliver, Prasun K. Mukherjee, Rosalba Lepore, Markus Alahuhta, Christopher S. Hayes, Andrea Ilari, Lucy Stols, Maya Topf, John Moult, Marcus D. Hartmann, Anastassis Perrakis, Andrew L. Lovering, Romain Linares, Valerio Chiarini, Karolina Michalska, Ann M. Arvin, Cihan Makbul, Torsten Schwede, Mauricio Valdivia-Delgado, Susan E. Tsutakawa, Gagan D. Gupta, Naga Babu Chinnam, Vladimir V. Lunin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca2b9cc3e1fc37a02fd623b5b63489c5
https://doi.org/10.1002/prot.26247/v2/response1
https://doi.org/10.1002/prot.26247/v2/response1
Autor:
Lucy Stols, Robert Jedrzejczak, Hugh O'Neill, Leighton Coates, Andrzej Joachimiak, Daniel W. Kneller, Gwyndalyn Phillips, Paul Langan, Andrey Kovalevsky
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
The COVID-19 disease caused by the SARS-CoV-2 coronavirus has become a pandemic health crisis. An attractive target for antiviral inhibitors is the main protease 3CL Mpro due to its essential role in processing the polyproteins translated from viral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8ba6d3fbeede0fe3f7724222fc0f74
Autor:
Daniel W. Kneller, Gwyndalyn Phillips, Hugh M. O'Neill, Robert Jedrzejczak, Lucy Stols, Paul Langan, Andrzej Joachimiak, Leighton Coates, Andrey Kovalevsky
The COVID-19 disease caused by the SARS-CoV-2 Coronavirus has become a pandemic health crisis. An attractive target for antiviral inhibitors is the main protease 3CL Mpro due to its essential role in processing the polyproteins translated from viral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0018583c0d7c54d72f188dba2b27a780
https://doi.org/10.21203/rs.3.rs-28669/v1
https://doi.org/10.21203/rs.3.rs-28669/v1
Autor:
Karolina Michalska, Dinh Quan Nhan, Christopher S. Hayes, Allison M. Jones, Andrzej Joachimiak, Celia W. Goulding, Lucy Stols, Julia L. E. Willett, David A. Low, William H. Eschenfeldt, Sanna Koskiniemi, Josephine Y. Nguyen
Publikováno v:
Molecular microbiology, vol 109, iss 4
Molecular Microbiology
Molecular Microbiology
Bacteria use several different secretion systems to deliver toxic EndoU ribonucleases into neighboring cells. Here, we present the first structure of a prokaryotic EndoU toxin in complex with its cognate immunity protein. The contact-dependent growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986fcb0631e4b3caeff4d49d06acef34
https://europepmc.org/articles/PMC6173971/
https://europepmc.org/articles/PMC6173971/
Autor:
Parker M. Johnson, Bryan Boubion, William H. Eschenfeldt, Celia W. Goulding, Gyorgy Babnigg, Lucy Stols, Andrezj Joachimiak, Christopher S. Hayes, Kemin Tan
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 71:702-709
Contact-dependent growth inhibition (CDI) is an important mechanism of intercellular competition between neighboring Gram-negative bacteria. CDI systems encode large surface-exposed CdiA effector proteins that carry a variety of C-terminal toxin doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc4f968dd3adb6e3064211b90b2ec0a
https://doi.org/10.1107/s2053230x15006585
https://doi.org/10.1107/s2053230x15006585
Autor:
Parker M. Johnson, Lucy Stols, Gyorgy Babnigg, William H. Eschenfeldt, Christopher S. Hayes, David A. Low, Celia W. Goulding, Andrzej Joachimiak, Karolina Michalska, Fernando Garza-Sánchez, Grant C. Gucinski
Publikováno v:
Nucleic acids research, vol 45, iss 17
Nucleic Acids Research
Nucleic Acids Research
Contact-dependent growth inhibition (CDI) is a mechanism of inter-cellular competition in which Gram-negative bacteria exchange polymorphic toxins using type V secretion systems. Here, we present structures of the CDI toxin from Escherichia coli NC10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be4d941c7262172ef5489e8f0bea71e
https://escholarship.org/uc/item/2dk2h951
https://escholarship.org/uc/item/2dk2h951
Autor:
Fernando Garza-Sánchez, William H. Eschenfeldt, Christopher S. Hayes, Grant C. Gucinski, Celia W. Goulding, Andrzej Joachimiak, Lucy Stols, Josephine Y. Nguyen, Karolina Michalska
Publikováno v:
Structure
Structure (London, England : 1993), vol 27, iss 11
Structure (London, England : 1993), vol 27, iss 11
Contact-dependent growth inhibition (CDI) is a form of interbacterial competition mediated by CdiB-CdiA two-partner secretion systems. CdiA effector proteins carry polymorphic C-terminal toxin domains (CdiA-CT), which are neutralized by specific CdiI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b085a9faa267e8eb07b01a6f3f9503
https://doi.org/10.1016/j.str.2019.08.010
https://doi.org/10.1016/j.str.2019.08.010