Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lucy Shu Nga Yeung"'
Autor:
Justin Hou Ming Yung, Lucy Shu Nga Yeung, Aleksandar Ivovic, Yao Fang Tan, Emelien Mariella Jentz, Battsetseg Batchuluun, Himaben Gohil, Michael B. Wheeler, Jamie W. Joseph, Adria Giacca, Mortimer Mamelak
Publikováno v:
Cells, Vol 11, Iss 3, p 545 (2022)
Oxidative stress caused by the exposure of pancreatic ß-cells to high levels of fatty acids impairs insulin secretion. This lipotoxicity is thought to play an important role in ß-cell failure in type 2 diabetes and can be prevented by antioxidants.
Externí odkaz:
https://doaj.org/article/44b1eb86430549c6be063c5a1787c91a
Autor:
Aleksandar Ivovic, Battsetseg Batchuluun, Mortimer Mamelak, Lucy Shu Nga Yeung, Yao Fang Tan, Adria Giacca
Publikováno v:
Diabetes. 68
Prolonged exposure to high levels of fatty acids impairs the insulin secretory capacity of pancreatic β-cells through mechanisms involving oxidative stress (lipotoxicity). Beta-cell lipotoxicity is thought to play an important role in the β-cell fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20534772f791c611a4afc6570f0310a6
https://doi.org/10.2337/db19-2167-p
https://doi.org/10.2337/db19-2167-p
Publikováno v:
Diabetes. 68
In obesity, chronically elevated circulating free fatty acids (FFA) potentially cause ß-cell dysfunction which leads to type 2 diabetes (T2D). In vitro data have identified various cellular mechanisms leading to FFA-induced ß-cell dysfunction inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1cd0c9194d69fca289e4c3b2e4b621b
https://doi.org/10.2337/db19-2472-pub
https://doi.org/10.2337/db19-2472-pub
Autor:
Kevin Tai, Liling Zhang, Christine Tang, Lucy Shu Nga Yeung, Allen Volchuk, Khajag Koulajian, Adria Giacca
Publikováno v:
Endocrinology. 159(11)
Prolonged elevation of glucose can adversely affect β-cell function. Oxidative stress, which has been implicated in glucose-induced β-cell dysfunction, can activate c-jun N-terminal kinase (JNK). However, whether JNK is causal in glucose-induced β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8641af0327ba84554b0c284ea40b88
https://pubmed.ncbi.nlm.nih.gov/30215691
https://pubmed.ncbi.nlm.nih.gov/30215691
Autor:
Yusaku Mori, Sydney L. Rivers, Kenny L. Chan, Amira Klip, Lucy Shu Nga Yeung, Dana J. Philpott, Adria Giacca
Publikováno v:
Diabetes. 67
Insulin resistance (IR) in type 2 diabetes (T2D) is associated with chronic low-grade inflammation. We have shown that nucleotide binding oligomerization domain (NOD)1, an intracellular pattern recognition receptor for bacterial wall peptidoglycans,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c53e2b335b4ccdc654cc68ba4759a54
https://doi.org/10.2337/db18-148-or
https://doi.org/10.2337/db18-148-or
Autor:
Elena Bogdanovic, Huogen Lu, Karen Ho, Charles Cho, Lucy Shu Nga Yeung, Lijiang Liu, Zhiwen Yu, Adria Giacca, Harinder S. Hundal, June Guo, Reiner Lehmann, I. George Fantus
Publikováno v:
Endocrinology. 159(4)
A hyperglycemic and hyperinsulinemic environment characteristic of type 2 diabetes causes insulin resistance. In adipocytes, defects in both insulin sensitivity and maximum response of glucose transport have been demonstrated. To investigate the mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c72ae01602b363b45b950854b211f0
https://pubmed.ncbi.nlm.nih.gov/29370351
https://pubmed.ncbi.nlm.nih.gov/29370351
Autor:
Nathan Swain, Prasad S. Dalvi, Danna M. Breen, Adria Giacca, June Guo, Troy J. Pereira, Vernon W. Dolinsky, Lucy Shu Nga Yeung, Loretta Lam
Publikováno v:
Metabolism: clinical and experimental. 68
Objective Our laboratory has shown that insulin's effect to decrease neointimal thickness after arterial injury is greatly diminished in insulin resistant conditions. Thus, in these conditions, a better alternative to insulin could be to use an insul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2f6896319c9b490d2db9164a396c81
https://pubmed.ncbi.nlm.nih.gov/28183442
https://pubmed.ncbi.nlm.nih.gov/28183442
Akademický článek
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Publikováno v:
Canadian Journal of Diabetes. 41:S33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91f6f67cdd37ddd917df86aaf63c7158
https://doi.org/10.1016/j.jcjd.2017.08.099
https://doi.org/10.1016/j.jcjd.2017.08.099