Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lucy S. Drury"'
Autor:
Berta Canal, Allison W. McClure, Joseph F. Curran, Mary Wu, Rachel Ulferts, Florian Weissmann, Jingkun Zeng, Agustina P. Bertolin, Jennifer C. Milligan, Souradeep Basu, Lucy S. Drury, Tom Deegan, Ryo Fujisawa, Emma L. Roberts, Clovis Basier, Karim Labib, Rupert Beale, Michael Howell, John F.X Diffley
Publikováno v:
Biochemical Journal
SummarySARS-CoV-2 is a coronavirus that emerged in 2019 and rapidly spread across the world causing a deadly pandemic with tremendous social and economic costs. Healthcare systems worldwide are under great pressure, and there is urgent need for effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fecacd84c888a43831e441cefbc679e
http://europepmc.org/articles/PMC8286829
http://europepmc.org/articles/PMC8286829
Autor:
Kang Wei Tan, Emma L. Roberts, Tiffany Mak, Lucy S. Drury, Souradeep Basu, Berta Canal, Michael Howell, Joseph F. Curran, Florian Weissmann, Karim Labib, Tom D Deegan, John F.X. Diffley, Allison W McClure, Ryo Fujisawa, Mary Wu, Victoria H. Cowling, Rachel Ulferts, Clovis Basier, Rupert Beale, Theresa U. Zeisner, Chew Theng Lim
Publikováno v:
Biochemical Journal
The COVID-19 pandemic has presented itself as one of the most critical public health challenges of the century, with SARS-CoV-2 being the third member of the Coronaviridae family to cause a fatal disease in humans. There is currently only one antivir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74acc162b19fe84f371a9c793c9d9297
http://europepmc.org/articles/PMC8286817
http://europepmc.org/articles/PMC8286817
Autor:
Chew Theng Lim, Kang Wei Tan, Mary Wu, Rachel Ulferts, Lee A. Armstrong, Eiko Ozono, Lucy S. Drury, Jennifer C. Milligan, Theresa U. Zeisner, Jingkun Zeng, Florian Weissmann, Berta Canal, Ganka Bineva-Todd, Michael Howell, Nicola O'Reilly, Rupert Beale, Yogesh Kulathu, Karim Labib, John F.X. Diffley
Publikováno v:
Biochemical Journal
The COVID-19 pandemic has emerged as the biggest life-threatening disease of this century. Whilst vaccination should provide a long-term solution, this is pitted against the constant threat of mutations in the virus rendering the current vaccines les
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc295ebc783870d82ca11f9dd713752
http://europepmc.org/articles/PMC8286840
http://europepmc.org/articles/PMC8286840
Publikováno v:
Molecular Systems Biology, Vol 5, Iss 1, Pp 1-8 (2009)
Abstract This report provides a global view of how gene expression is affected by DNA replication. We analyzed synchronized cultures of Saccharomyces cerevisiae under conditions that prevent DNA replication initiation without delaying cell cycle prog
Externí odkaz:
https://doaj.org/article/d2cd4856c7454d93aa455a9e115e43f7
Autor:
Florian Weissmann, Berta Canal, Rachel Ulferts, Mary Wu, Michael Howell, John F.X. Diffley, Lucy S. Drury, Jennifer C. Milligan, Rupert Beale, Jingkun Zeng, Agustina P Bertolin, Viktor Posse
Publikováno v:
Biochemical Journal
SummaryThe coronavirus disease 2019 (COVID-19) global pandemic has turned into the largest public health and economic crisis in recent history impacting virtually all sectors of society. There is a need for effective therapeutics to battle the ongoin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e349d752e1f3eb65b7e78de708e1dc8d
https://doi.org/10.1101/2021.04.07.438807
https://doi.org/10.1101/2021.04.07.438807
Autor:
John W. McCauley, Ruth Harvey, Mary Wu, Laura E. McCoy, Agustina P Bertolin, Viktor Posse, Rupert Beale, Lucy S. Drury, John F.X. Diffley, Svend Kjaer, Saira Hussain, Berta Canal, Annabel Borg, Florian Weissmann, Jingkun Zeng, Jennifer C. Milligan, Rachel Ulferts, Michael Howell, Chloe Roustan
Publikováno v:
Biochemical Journal
SummaryThe coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global public health challenge. While the efficacy of vaccines against emerging and future virus variants re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2be294aa30a2fa0bdf7de7e17f9f7f6
https://doi.org/10.1101/2021.04.07.438808
https://doi.org/10.1101/2021.04.07.438808
Origins of eukaryotic DNA replication are ‘licensed’ during G1 phase of the cell cycle by loading the six related minichromosome maintenance (MCM) proteins into a double hexameric ring around double-stranded DNA. In S phase, some double hexamers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca203e8624615302ad31383a4f40dd8
https://doi.org/10.1101/2020.09.17.301366
https://doi.org/10.1101/2020.09.17.301366
Autor:
John F.X. Diffley, Lucy S. Drury
Publikováno v:
Current Biology. 19:530-535
SummaryReplication of eukaryotic genomes is limited to once per cell cycle, by a two-step mechanism [1, 2]. DNA replication origins are first “licensed” during G1 phase by loading of an inactive DNA helicase (Mcm2-7) into pre-replicative complexe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3c86a19ae345e6aa128a7973fa787f
https://doi.org/10.1016/j.cub.2009.02.034
https://doi.org/10.1016/j.cub.2009.02.034
Publikováno v:
Current Biology. 10(5):231-240
Background: Cdc28p, the major cyclin-dependent kinase in budding yeast, prevents re-replication within each cell cycle by preventing the reassembly of Cdc6p-dependent pre-replicative complexes (pre-RCs) once origins have fired. Cdc6p is a rapidly deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86a92b526ff139db192a971df83a7b1
Publikováno v:
Molecular and Cellular Biology. 20:242-248
The Dbf4p/Cdc7p protein kinase is essential for the activation of replication origins during S phase. The catalytic subunit, Cdc7p, is present at constant levels throughout the cell cycle. In contrast, we show here that the levels of the regulatory s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f7fef4689c9cb9c572cca8dbee0efc
https://doi.org/10.1128/mcb.20.1.242-248.2000
https://doi.org/10.1128/mcb.20.1.242-248.2000